DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and tmtc2

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001096156.1	Gene:	tmtc2 / 100124656	XenbaseID:	XB-GENE-948541	Length:	836	Species:	Xenopus tropicalis

Alignment Length:	916	Identity:	339/916 - (37%)
Similarity:	482/916 - (52%)	Gaps:	116/916 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLC 100
            |...:|..|||||||||.|.|||.|||..|.|:...|||...|.||||||.||.||||.|:||||
Frog     5 LLSSALGLVLYLNTLGADFCYDDSRAIKTNQDLLPETPWNHIFFNDFWGTLLTHSGSHKSYRPLC 69

  Fly   101 VLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAV 165
            .||||||||: ||..||.:||||.|||...|.|...:.:.|..|....|.||.|||:||||||||
Frog    70 TLSFRLNYLL-GGLDPWSYHLVNILLHSAVTGLFTNLCKALFGSGCWTLIAGLLFASHPIHTEAV 133

  Fly   166 AGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQWLALGATLILAAAGLLCKETAITALLVCA 230
            ||:|||||:.|.:.:||:.|.|::|...| ......|..:......||..:|.||..:|.|.|.|
Frog   134 AGIVGRADVGAGLFFLLSLLCYMKHCSTR-GYSLSSWCWILCAGFWAACSMLWKEQGVTVLAVSA 197

  Fly   231 LFDV-------MRGLSGQVDKQRLRSVCIVLGALFCMAYCRLVI----VPGPQTAFSSADNPIAR 284
            ::|:       |..:...|.|::..|....:|.||......|.:    :.....:||::|||.|.
Frog   198 VYDIFVFHKLKMNQIISVVFKRKNVSFFFSVGLLFAWGVVLLGVRFYWMGNTPPSFSNSDNPAAD 262

  Fly   285 TPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWGS 349
            .....||.|||.|||..||.||..|:.|||||.|||:|.:.::.|.||..:..|:.:|:.:::.|
Frog   263 CEVLLTRTLTFFYLPTKNLWLLFCPDTLSFDWSMDAVPLIKTIIDWRNIHTVAFHILLILLSYSS 327

  Fly   350 CRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCRD 414
                |.||                                                   |:. ||
Frog   328 ----LKGS---------------------------------------------------AMK-RD 336

  Fly   415 CNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSSSL 479
            ||     |.::...                           .::||..|..|.....::.....:
Frog   337 CN-----GKLFMNG---------------------------KHNTNGHSCQSDLEHKNAEQKPVI 369

  Fly   480 SGGFQCSSKDYALEGMS-PANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVGFC 543
            :...:...|.:....|. |:.::  :::::||.|.:||:|||||.||||||:|||:||:||:|||
Frog   370 ASKLENGIKHHISHEMQLPSTKN--IVVLALSLLIVPFVPASNLFFYVGFVIAERVLYIPSMGFC 432

  Fly   544 LLVGYGVSKLMSCNQRT--RNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINPPKALG 606
            |||..|...|....|:.  :::|..:.:.|:....|:|:.||.||::||.||||.|.:||.||.|
Frog   433 LLVTVGARALYIKAQKNFLKSLLFYATTALIVFYGLKTVVRNGDWKNEEMLYRSGIKVNPAKAWG 497

  Fly   607 NLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKFRPNLAV 671
            |||:||.||.:.:||:...:.|:.:|.||||:.:|||:|.|....:..|:..::.||..||.||.
Frog   498 NLGNVLKSQSKIDEAENAYRNALYYRSNMADMLYNLGLLLQENSKFSEALHYYKLAIGSRPTLAS 562

  Fly   672 AYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALA 736
            .|||.||..:..|:.::|.......|.:....::|..||..:.:|....||.||.|||:.:.||.
Frog   563 GYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPNAHKSSVTSCLYNLGKLYHEQGQYEDALI 627

  Fly   737 IYREALSSLPG--LPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSYG--ITL 797
            :|:||:..:|.  .||.   ||..:|:...||....|||..:..:|:.:|:.:.|||:||  :||
Frog   628 VYKEAIQKMPRQFSPQS---LYNMMGEAYMRLNLVSEAEHWYTESLKSKPDHIPAHLTYGKLLTL 689

  Fly   798 ARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYTLVVAA 862
               :.|.:|||.:|.:|::|.|.:.:.|.||.:||..:.|..|:|...::||||..:::.:|..|
Frog   690 ---TGRKNEAERYFLKAIQLDPNKGNCYMHYGQFLLEEGRLLEAAEMAKKAAELDNSEFDVVFNA 751

  Fly   863 ATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGDAITL 927
            |..:|.......||.:|:.|..|||....|..||||||||.|:...|.::|..||:|:|.||||.
Frog   752 AHMLRQASLNEAAEKYYKLAAGLRPNYPAALMNLGAILHLNGKLEEAESNYLRALQLKPDDAITQ 816

  Fly   928 GNLAKL 933
            .||.||
Frog   817 SNLRKL 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	53/119 (45%)
		DUF1736	275..343	CDD:285594	32/67 (48%)
		TPR_11	602..667	CDD:290150	26/64 (41%)
		TPR_1	602..634	CDD:278916	14/31 (45%)
		TPR repeat	602..630	CDD:276809	13/27 (48%)
		TPR repeat	635..665	CDD:276809	11/29 (38%)
		TPR_11	636..700	CDD:290150	22/63 (35%)
		TPR_1	636..668	CDD:278916	11/31 (35%)
		TPR repeat	670..694	CDD:276809	8/23 (35%)
		TPR_11	714..784	CDD:290150	25/71 (35%)
		TPR repeat	715..743	CDD:276809	13/27 (48%)
		TPR repeat	748..782	CDD:276809	11/33 (33%)
		TPR_11	755..819	CDD:290150	24/65 (37%)
		TPR repeat	787..816	CDD:276809	13/30 (43%)
		TPR_11	821..887	CDD:290150	21/65 (32%)
		TPR repeat	822..850	CDD:276809	9/27 (33%)
		TPR repeat	855..885	CDD:276809	8/29 (28%)
		TPR_11	<874..921	CDD:290150	22/46 (48%)
		TPR repeat	890..918	CDD:276809	13/27 (48%)
tmtc2	NP_001096156.1	PMT_2	43..244	CDD:389829	89/202 (44%)
		DUF1736	247..316	CDD:369859	31/68 (46%)
		PEP_TPR_lipo	<461..821	CDD:274350	143/365 (39%)
		TPR repeat	493..521	CDD:276809	13/27 (48%)
		TPR repeat	526..556	CDD:276809	11/29 (38%)
		TPR repeat	561..589	CDD:276809	8/27 (30%)
		TPR repeat	601..634	CDD:276809	14/32 (44%)
		TPR repeat	642..671	CDD:276809	10/31 (32%)
		TPR repeat	676..706	CDD:276809	13/32 (41%)
		TPR repeat	779..807	CDD:276809	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	195	1.000	Domainoid score	I3092
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25521
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1027
OMA	1	1.010	-	-		QHG52430
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0004694
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3302
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080