DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GLR3.3

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001322169.1	Gene:	GLR3.3 / 840859	AraportID:	AT1G42540	Length:	933	Species:	Arabidopsis thaliana

Alignment Length:	1061	Identity:	224/1061 - (21%)
Similarity:	372/1061 - (35%)	Gaps:	282/1061 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MWSAF---FMC-----RSRGQQ---INIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLI 64
            :|:.|   |:|     |:..::   :.||:.|..|.:..:...:.:..|:....|...:
plant     4 LWTFFFLSFLCSGLFRRTHSEKPKVVKIGSIFSFDSVIGKVAKIAIDEAVKDVNSNPDI------ 62

  Fly    65 KRLKPEDGSVTMQEHACD----------LIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDI 119
              |.....||:||...|.          .::..:..|.||.....:.:::.:.|...:|.:.|.:
plant    63 --LSGTKFSVSMQNSNCSGFMGMVEALRFMEKDIVGIIGPQCSVVAHMISHMANELRVPLLSFAV 125

  Fly   120 SDEGIQ-AEKPNHQMTL--NLYPAQAILSKAYADIVQNFGWRKFTIVYDADD--ARAAARLQDLL 179
            :|..:. .:.|....|.  :||...||     |.||..:||::...|:..||  ....|.|.|.|
plant   126 TDPVMSPLQFPYFIRTTQSDLYQMDAI-----ASIVDFYGWKEVIAVFVDDDFGRNGVAALNDKL 185

  Fly   180 QLRE--------VHNDVVRVRKFHKDDDFRVMWK-SIRGERRVVLDCEPNMLVELLNSSTEFGLT 235
            ..|.        :|.|..    .:|::...::.| .:...|.||:.....:...:...:...|:.
plant   186 ASRRLRITYKAGLHPDTA----VNKNEIMNMLIKIMLLQPRIVVIHVYSELGFAVFKEAKYLGMM 246

  Fly   236 GQ-YNHIFLTNLETYTDHLEELAADN-ETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYES 298
            |. |..|....|.|..|....|.|:. ||.     ...|::.|..|                  .
plant   247 GNGYVWIATDWLSTNLDSSSPLPAERLETI-----QGVLVLRPHTP------------------D 288

  Fly   299 SDPPRTLIHDLIHDALQLFAQSWRNAS-----------FFYPDRMVVPRITCDFAASGGRTWAMG 352
            ||..|.            |.:.||..|           :.|...|::.|....|...||......
plant   289 SDFKRE------------FFKRWRKMSGASLALNTYGLYAYDSVMLLARGLDKFFKDGGNISFSN 341

  Fly   353 RYLARLMKGTSGVNNTNFR-----------------------TSILQFDEDGQRITFNIEVYDPL 394
            ..:...: |.||  |.|..                       |..|||..|..|..   ..||.:
plant   342 HSMLNTL-GKSG--NLNLEAMTVFDGGEALLKDILGTRMVGLTGQLQFTPDRSRTR---PAYDII 400

  Fly   395 D--GIGI------------------------------------AIW------DPRGQITQLNVDV 415
            :  |.|:                                    .||      .|||.:...|
plant   401 NVAGTGVRQIGYWSNHSGLSTVLPELLYTKEKPNMSTSPKLKHVIWPGETFTKPRGWVFSNN--- 462

  Fly   416 KAQKKMIYRVATRIGPPY-FSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQ 479
              .|::      :||.|. .||.|...::..|.| :::|:.:|:..|....:.:.   |||....
plant   463 --GKEL------KIGVPLRVSYKEFVSQIRGTEN-MFKGFCIDVFTAAVNLLPYA---VPVKFIP 515

  Fly   480 YGKLDKETKQWNGIIGEII---NNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVE 541
            ||. .||...:..:: |:|   |.|..:|  |:.|...|...||||.|:...|:.::|   |.
plant   516 YGN-GKENPSYTHMV-EMITTGNFDGVVG--DVAIVTNRTKIVDFTQPYAASGLVVVA---PF-- 571

  Fly   542 KTLD----AYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCN---RDP---EVLEN 596
            |.|:    |:|.||...:|   .::.....|:..:|       |...|..|   |.|   :.:..
plant   572 KKLNSGAWAFLRPFNRLMW---AVTGCCFLFVGIVV-------WILEHRTNDEFRGPPKRQCVTI 626

  Fly   597 QWRIHNTGWLT--VASIMTAGCDILPRSPQVRMFEATWWIFAIIIAN-SYTANLAAFLTSSKMEG 658
            .|...:|.:..  ..::.|.|..:|           ..|:|.::|.| ||||:|.:.||..::..
plant   627 LWFSFSTMFFAHRENTVSTLGRLVL-----------IIWLFVVLIINSSYTASLTSILTVQQLSS 680

  Fly   659 SIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNN-----DDPSAYTKDNLEGVD 718
            .|..::.| .::....|...|...        |:..|...|:..:     ..|.||.|...:|..
plant   681 PIKGIESL-RERDDPIGYQVGSFA--------ESYLRNELNISESRLVPLGTPEAYAKALKDGPS 736

  Fly   719 RVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERG 783
            :    .|....:.|...:|.....||..|.||::|.:..:..|.|..:....:||.|||:|:|.|
plant   737 K----GGVAAIVDERPYVELFLSSNCAYRIVGQEFTKSGWGFAFPRDSPLAIDLSTAILELAENG 797

  Fly   784 ELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVAL 848
            :|..:..||... ||...|..:.: :..:..:...|:|  |..|  :|.|:.:  ||.:||.:..
plant   798 DLQRIHDKWLMK-NACTLENAELE-SDRLHLKSFWGLF--LICG--VACLLAL--FLYFVQIIRQ 854

  Fly   849 EERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSE 913
            ..:....||..::.:      .|...       ||:|:|..:.....:|...:|..        |
plant   855 LYKKPTDDAIARDQQ------QNHDS-------SSMRSTRLQRFLSLMDEKEESKH--------E 898

  Fly   914 EMREMAQGSGSSSGSNNAGRG 934
            ..:....||.:.:..:...||
plant   899 SKKRKIDGSMNDTSGSTRSRG 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	89/481 (19%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	15/94 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	98/392 (25%)
		Lig_chan	554..828	CDD:278489	64/287 (22%)
GLR3.3	NP_001322169.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020