DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and ATGLR1.2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_199651.1	Gene:	ATGLR1.2 / 834895	AraportID:	AT5G48400	Length:	867	Species:	Arabidopsis thaliana

Alignment Length:	953	Identity:	184/953 - (19%)
Similarity:	342/953 - (35%)	Gaps:	267/953 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLID-NGVAAIFGP 94
            |||:..:.:.....:|...:|.         ||:           ..:...||:. .||.||.|.
plant    67 FYDNHNDYKTRLSLLVRDSHGE---------PLL-----------ALDSVVDLLQTEGVQAIIGG 111

  Fly    95 SSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH--QMTLNLYPAQAILSKAYADIVQNFGW 157
            :|...:.::|.:.....:|.|..: |...:...|..|  |.|.|    .|...|.....:..|.|
plant   112 NSLLEAKLLAELGEKARVPVISLN-SPMSLSLSKYTHLIQATHN----SASEVKGITAFLHGFDW 171

  Fly   158 RKFTIVY-DADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRGERRVV--LDCEP 219
            ....:|. |.||.|.:....              |..||::        ::..:.:|.  :....
plant   172 NSVALVLEDHDDWRESMHFM--------------VDHFHEN--------NVHVQSKVAFSVTSSE 214

  Fly   220 NMLVELLNSSTEFGLTGQYNHIFLTNL-ETYTDHL----EELAADNETFAVNITAARLLVNPDPP 279
            :.|::.|....:.|.|     :|:.:| |.....|    |:|....|.||..:|:..:....|.
plant   215 DSLMDRLRELKDLGTT-----VFVVHLSEVIATRLFPCAEKLGMMGEGFAWILTSRSMSSFHDQ- 273

  Fly   280 PYSLPYGYVTQRDNIVYESSD---------PPRTLIHDLIHDALQLFAQSWRNASFFYPDRMV-- 333
                   ::   |::..|:.:         |....:|:        |...||..   .|...|
plant   274 -------FI---DDLTKEAMEGVVGFKSYIPMSKELHN--------FTLRWRKT---LPVEEVTG 317

  Fly   334 --VPRITC------DFA---ASGGRTWAMGRYLARLM--------KGTSGVNNTNFRTSILQFDE 379
              :.|::.      |.|   ||......|....:.|:        ||.||    ||:.      :
plant   318 SEITRLSISGVWAHDVAWSLASAAEVTRMPTVTSTLLEAIKESRFKGLSG----NFQL------D 372

  Fly   380 DGQRITFNIEVYDPLDGIG---IAIWDPRGQIT---QLNVDVKAQKKMIYRVATRIGPPYFSYNE 438
            |.:.::...|:.:.: |.|   :..|:..|..:   ||:......:.:|:...:...|...|..|
plant   373 DMKLLSDKFEIVNMI-GSGERRVGFWNSNGSFSNRRQLSSTHDNLETIIWPGGSAQSPKGRSLRE 436

  Fly   439 TARE----LNLTGN-----------------ALYQGYAVDLIDAIARHVGFEYVFVP-VADQQYG 481
            :.|:    |..:.|                 .:.:|:.:::..|......:|..::. :....|.
plant   437 SGRKKLRVLVTSSNRFPRLMKVETDPITHEITIVEGFCIEVFQASIAPFNYEVEYIRWLNGTNYT 501

  Fly   482 K----LDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEK 542
            |    |..:..:::..:|            |:|||..|...||||:|:.::|:.|:|.|    |:
plant   502 KLAYALHSQKDKYDAAVG------------DITITSDRSMYVDFTLPYTEMGLGIVAAK----ER 550

  Fly   543 TLDAYLAPFGGEVWIWILISVFVMT-FLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWL 606
            ::..:..|....:|| ...:.||:| .:..::.|....:::...|           .:|....|.
plant   551 SMWVFFQPLTPNLWI-TSAAFFVLTGIIVWLIERAENKEFQGSWP-----------QQIGVVIWF 603

  Fly   607 TVASIMTAGCDILPRSPQVRMFEATWWIFAI-IIANSYTANLAAFLTSSKMEGSIANLKDLSAQK 670
            ..::::.|..:.|..:  :..|..|.|:||: |:..||||.|.:.:|                .:
plant   604 GFSTLVYAHREKLQHN--LSRFVVTVWVFAVLILVTSYTATLTSMMT----------------VQ 650

  Fly   671 KVKFGTIYGGSTYNLLADSNET-VYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRG-DYMFLMET 733
            :::|             ::||. |..|:.:|:.|   :|.|..:|..:..:..|.. ||...:..
plant   651 QIRF-------------NANEDYVGHLSGSLIAN---AALTNSSLRAMRLLGLNTSEDYAQALMN 699

  Fly   734 TTLEYHREQNCDLR-SVGEKFGE----------KHYAIAVPFGAEYRSNLSVAILKLSERGELYD 787
            .::.|...:...|: .:||..|.          ..:......|:|...|:|..|.||.....|.:
plant   700 KSVSYIVSELPYLKILLGENPGHFLMVKTQSTTNGFGFMFQKGSELAPNVSREIAKLRTSERLNE 764

  Fly   788 LKQKWWKNPNASCFEEPDPDATPD----MTFEELRGIFYTLYAGILIAFLIGIT---------EF 839
            ::::|        |::..|..|.|    :|....||:|  :..|:..||.:.:.         |.
plant   765 MERRW--------FDKQLPYTTDDTSNPITLYRFRGLF--MITGVSFAFALAVLLILWLRERWEI 819

  Fly   840 LVYVQQVALEERLT-FKDAFKKEIRFVLCVWNNRKPIVAGTPI 881
            ||....:...:||. |:..|.:.|        :..|:....||
plant   820 LVNSVNIYFSQRLRHFRILFTRTI--------HPSPLGLDNPI 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	79/416 (19%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/113 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	79/411 (19%)
		Lig_chan	554..828	CDD:278489	58/292 (20%)
ATGLR1.2	NP_199651.1	PBP1_GABAb_receptor	41..407	CDD:107361	80/424 (19%)
		ANF_receptor	55..387	CDD:279440	76/403 (19%)
		GluR_Plant	440..770	CDD:270404	75/399 (19%)
		Lig_chan	563..801	CDD:278489	59/293 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070