DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GLR2.6

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001330285.1	Gene:	GLR2.6 / 830988	AraportID:	AT5G11180	Length:	967	Species:	Arabidopsis thaliana

Alignment Length:	829	Identity:	165/829 - (19%)
Similarity:	301/829 - (36%)	Gaps:	158/829 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQA------EKPNHQMTLNLYPAQAILSK 146
            |.||.||.:...:..:..:.|.:.:|.|.|..|...:.:      .:..|..:..::
plant   101 VVAIIGPGNSMQAPFLINLGNQSQVPIISFSASSPVLDSLRSPYFIRATHDDSSQVH-------- 157

  Fly   147 AYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVR---KFHKDDDF--RVMWKS 206
            |.:.|:::|.||:...:| ||:......|..|:...:..|..:|.|   ..|..||.  :.::|.
plant   158 AISAIIESFRWREVVPIY-ADNEFGEGILPYLVDAFQEINVRIRYRSAISVHSTDDLVKKELYKL 221

  Fly   207 IRGERRV-VLDCEPNMLVELLNSSTEFG-LTGQYNHIFLTNLETYTDHLEELAADNETFAVNITA 269
            :....|| ::...|::...|.:.:.|.| :|..|..|....:......:.|.:.:|....:.:..
plant   222 MTMPTRVFIVHMLPDLGSRLFSIAKEIGMMTKGYVWIVTNGIADQMSVMGESSLENMHGVLGVKT 286

  Fly   270 ARLLVNPDPPPYSLPYGYVTQRDNIVYESS-------------------DPPRTL---IHDLIHD 312
                             |.::...::|..:                   |....|   |.::..:
plant   287 -----------------YFSRSKELMYLETRWRKRFGGEELNNFECWGYDTATALAMSIEEISSN 334

  Fly   313 ALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARL-MKGTSG--------VNNT 368
            ....|:|:.||.|   .|..........||.||.:   :.:.||.: .||.:|        :..|
plant   335 VNMSFSQTKRNTS---RDDTGTDLDDLSFALSGPK---LLQALATVSFKGVAGRFQLKNGKLEAT 393

  Fly   369 NFRTSILQFDEDGQR-----------------------ITFNIEVYDPLDGIGIAIWDPRGQITQ 410
            .|:  |:..:|.|:|                       |:.:.....|:...|..|:.|:|....
plant   394 TFK--IVNIEESGERTVGFWKSKVGLVKSLRVNQTGIKISHSSHRLRPIIWPGDTIFVPKGWEFP 456

  Fly   411 LNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARH----VGFEYV 471
            .|.     ||:  |:|......:.::.|..::.| |......|:.:|:.|...|.    |.:||:
plant   457 TNA-----KKL--RIAVPKKDGFNNFVEVTKDAN-TNAPTITGFCIDVFDTAMRQMPYAVPYEYI 513

  Fly   472 FVPVAD-QQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAY 535
            .....| :..|..|:..  ::..:||.   |..:|  |.||...|.|.|||.:|:.:.|:.::..
plant   514 PFETPDGKPRGSYDEMV--YHVFLGEF---DGAVG--DTTILANRSTYVDFALPYSETGIVVVVP 571

  Fly   536 KSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRI 600
            .....||....:|.|...|:|.....|...:..:..|....:..|:......|          :|
plant   572 VKDEREKGKWVFLKPLTRELWFLTAASFLYIGIMVWIFEYQASGDFRKQSIIN----------KI 626

  Fly   601 HNTGWLTVASIMTAGCDILP-RSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLK 664
            .|..:.:.:::..|  .:.| .|...|:....|....:|:..||||.|.:.||..::..::.::.
plant   627 SNVFYFSFSTLFFA--HMRPSESIFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMD 689

  Fly   665 DLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSA-----YTKDNLEGVDRVRKNR 724
            || ....|..|...|..|:..|........|    |...|.|..     ..|.:..|:|..
plant   690 DL-RNSGVNIGYQTGSFTFERLKQMGYKESR----LKTYDTPQEMHELFLKKSSNGGIDAA---- 745

  Fly   725 GDYMFLMETTTLEYHREQNCDLRSVGE-KFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDL 788
                 ..|...::....:.|...::.| .|....:..|.|.|:....:||..||.::|...:..:
plant   746 -----FDEVAYVKLFMAKYCSKYTIIEPTFKADGFGFAFPLGSPLVPDLSRQILNITEGETMKAI 805

  Fly   789 KQKWWKNPNASCFEEPDPDATPDM---TFEELRGIFYTLYAGILIAFLI 834
            :.||... ...|.:....|:...:   :||.|..|.:.:...:|:|.|:
plant   806 ENKWLLG-EKHCLDSTTSDSPIRLDHHSFEALFTIVFVVSMLLLLAMLV 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	69/382 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	19/106 (18%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	82/382 (21%)
		Lig_chan	554..828	CDD:278489	55/283 (19%)
GLR2.6	NP_001330285.1	PBP1_GABAb_receptor_plant	38..421	CDD:380645	65/353 (18%)
		GluR_Plant	460..810	CDD:270404	83/385 (22%)
		Lig_chan	590..842	CDD:365843	55/278 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.070