DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GLUR2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001320141.1	Gene:	GLUR2 / 829682	AraportID:	AT4G35290	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	946	Identity:	193/946 - (20%)
Similarity:	339/946 - (35%)	Gaps:	257/946 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLI---KRLK------PEDGSVTM 76
            |.:.:::||.|....|:.|      |..|....:|:.:...|..   .:|:      ..:|.:|:
plant    26 RPRYVDVGAIFSLGTLQGE------VTNIAMKAAEEDVNSDPSFLGGSKLRITTYDAKRNGFLTI 84

  Fly    77 QEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQA-EKPNHQMTLNLYPA 140
            . .|...::....||.||.:...:.:::.:.|...:|.:.|...|..:.| :.|....|.   |:
plant    85 M-GALQFMETDAVAIIGPQTSIMAHVLSHLANELSVPMLSFTALDPSLSALQFPFFVQTA---PS 145

  Fly   141 QAILSKAYADIVQNFGWRKFTIVYDADD---------------ARAAARLQDLLQL-------RE 183
            ...|.:|.|:::..:||.:...:|:.||               .|.....:.:|.|       ||
plant   146 DLFLMRAIAEMISYYGWSEVIALYNDDDNSRNGITALGDELEGRRCKISYKAVLPLDVVITSPRE 210

  Fly   184 VHNDVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQ-YNHIFLTNLE 247
            :.|::|:::...              .|.::::..|....::...:.:.|:..: |..|..|.|.
plant   211 IINELVKIQGME--------------SRVIIVNTFPKTGKKIFEEAQKLGMMEKGYVWIATTWLT 261

  Fly   248 TYTDHLEELAA--------------------------------DNETFAVNITAARLLVNPDPPP 280
            :..|.:..|.|                                .|.|..:|:
plant   262 SLLDSVNPLPAKTAESLRGVLTLRIHTPNSKKKKDFVARWNKLSNGTVGLNV------------- 313

  Fly   281 YSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASG 345
            |.| |.|.|     |:            :|..|::....|..|.||...     |::|   :..|
plant   314 YGL-YAYDT-----VW------------IIARAVKRLLDSRANISFSSD-----PKLT---SMKG 352

  Fly   346 GRTWAMGRYLARLMKGTSGVN---NTNFR--TSILQFDEDGQRITFNIEVYDPLDG--------- 396
            |.:..:|. |:...:|:..::   |||..  |..:||..|...|..:.::.:.:|.
plant   353 GGSLNLGA-LSIFDQGSQFLDYIVNTNMTGVTGQIQFLPDRSMIQPSYDIINVVDDGFRQIGYWS 416

  Fly   397 --IGIAIWDPRGQITQLNVDVKAQKKMIYRVA--------------------TRIG-PPYFSYNE 438
              .|::|..|.....:|: :..:..:.:..|.                    .||| |...|:.|
plant   417 NHSGLSIIPPESLYKKLS-NRSSSNQHLNNVTWPGGTSETPRGWVFPNNGRRLRIGVPDRASFKE 480

  Fly   439 TARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINN--- 500
            ....|:  |:...||||:|:.:|..:.:.:.   ||.....:|...|     |....|.:||
plant   481 FVSRLD--GSNKVQGYAIDVFEAAVKLISYP---VPHEFVLFGDGLK-----NPNFNEFVNNVTI 535

  Fly   501 ---DAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLD---AYLAPFGGEVWIWI 559
               ||.:|  |:.|...|...||||.|:::.|:.::|    .|.|..|   |:|.||...:|. :
plant   536 GVFDAVVG--DIAIVTKRTRIVDFTQPYIESGLVVVA----PVTKLNDTPWAFLRPFTPPMWA-V 593

  Fly   560 LISVFVMTFLKTIVARISKMDWENPHPCN---RDP---EVLENQWRIHNTGWLT--VASIMTAGC 616
            ..:.|::         :..:.|...|..|   |.|   :::...|...:|.:.:  ..::.|.|.
plant   594 TAAFFLI---------VGSVIWILEHRINDEFRGPPRKQIVTILWFSFSTMFFSHRENTVSTLGR 649

  Fly   617 DILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDL-SAQKKVKFGTIYGG 680
            .:|          ..|....:||.:||||:|.:.||..::...|..:..| |:..:|.|..  |.
plant   650 AVL----------LIWLFVVLIITSSYTASLTSILTVQQLNSPIRGVDTLISSSGRVGFQV--GS 702

  Fly   681 STYNLLADSNETVYRLAFNLMNN-----DDPSAYTKDNLEGVDRVRKNRGDY--MFLMETTTLEY 738
            ...|.:.|.        .|:..:     ..|..|......|......:...|  :||.|.
plant   703 YAENYMIDE--------LNIARSRLVPLGSPKEYAAALQNGTVAAIVDERPYVDLFLSEF----- 754

  Fly   739 HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEE 803
                 |.....|::|....:..|.|..:....::|.|||.|||.|:|..:..||....|.|...
plant   755 -----CGFAIRGQEFTRSGWGFAFPRDSPLAIDMSTAILGLSETGQLQKIHDKWLSRSNCSNLN- 813

  Fly   804 PDPDATPDMTFEELR-----GIFYTLYAGILIAFLI 834
               .:..|...|:|:     |:|........||..|
plant   814 ---GSVSDEDSEQLKLRSFWGLFLVCGISCFIALFI 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	83/458 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	19/83 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	97/416 (23%)
		Lig_chan	554..828	CDD:278489	61/294 (21%)
GLUR2	NP_001320141.1	PBP1_GABAb_receptor_plant	31..422	CDD:380645	82/454 (18%)
		GluR_Plant	466..804	CDD:270404	95/393 (24%)
		Lig_chan	590..840	CDD:395014	61/293 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020