DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GLR2.4

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001328410.1	Gene:	GLR2.4 / 829299	AraportID:	AT4G31710	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	931	Identity:	189/931 - (20%)
Similarity:	339/931 - (36%)	Gaps:	218/931 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDN-GVAAIFGPSSKAASDIVALVCNSTGIPHI 115
            |||...:    |:......|..|.....|.|||.| .|.||.||.:...:..|..|...:.:|.|
plant    87 PESRTRL----LLNFADSRDDVVGAAAAALDLIKNKEVKAILGPRTTMQASFVIEVGQKSQVPII 147

  Fly   116 EFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYD--ADDARAAARLQDL 178
            .|..:...:.:.:..:........:..:  :|.::|::.||||:...||:  |........|.|.
plant   148 SFSATSPFLDSGRSPYFFRSTYDDSSQV--QAISEIIKVFGWREVVPVYENNAFGEGIMPGLTDA 210

  Fly   179 LQ---LREVHNDVVRVRKFHKDDDFRV-MWKSIRGERRV-VLDCEPNMLVELLNSSTEFGL---- 234
            ||   :|..:..|:....  .||:..| :.|.:....|| |:.....:...:.:.:.|.||
plant   211 LQAINIRIPYRTVISPNA--TDDEISVDLLKLMTKPTRVFVVHMNRFLASRVFSKARETGLMKQG 273

  Fly   235 ------TGQYNHIFLTN------------LETYTDHLEELAADNETFAVNITAARLLVNPDPPPY 281
                  .|..:|:.|.|            :.|:....|||.......|.....:.|.:      |
plant   274 YAWILTNGVIDHLVLMNGTDIEAMQGVIGIRTHFPISEELQTFRSRLAKAFPVSELNI------Y 332

  Fly   282 SL-PYGYVTQRDNIVYESSDPPRTL-------IHDLIHDALQLFAQSWRNASFFYPDRMVVPRIT 338
            .| .|...|.....|.|:.....|.       |.||  :||.:..         |..:::
plant   333 GLRAYDATTALAMAVEEAGTTNLTFSKMDGRNISDL--EALSVSE---------YGPKLI----- 381

  Fly   339 CDFAASGGRTWAMGRYLARL-MKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAI- 401
                          |.|::: .||.||  :.:|        .|||......|:.:.:||.||.:
plant   382 --------------RSLSQIQFKGLSG--DYHF--------VDGQLHASVFEIVNVIDGGGILVG 422

  Fly   402 -W-DPRGQITQLN-----------------------VDVKAQKKMIYRVAT-----RIGPPYFSY 436
             | ..:|.:..|:                       :.:...|.  :.:.|     :||.|..::
plant   423 FWTQDKGLVKDLSPSSGTTRTFSSWKNHLNPILWPGITLTVPKG--WEIPTNGKELQIGVPVGTF 485

  Fly   437 NETARELN--LTGNALYQGYAVDLIDAIARHVGFE--YVFVPVADQQYGKLDKETKQWNGIIGEI 497
            .:..:...  ||...:..|:.:|..:|:.:.:.::  :.|:|..|.. ||.:
plant   486 PQFVKVTTDPLTHETIVTGFCIDFFEAVIQAMPYDVSHRFIPFGDDD-GKTN------------- 536

  Fly   498 INNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILIS 562
                      |.||...|.:.||||:|:...||.::.....:|.::...:..|....:|...|.|
plant   537 ----------DTTILANRSSYVDFTLPYTTSGVGMVVPLKDNVARSSLIFFKPLTPGLWGMTLGS 591

  Fly   563 VFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRM 627
            .||:.|:..|:......::..|           .|::|....|...:.::.|     ||. :|..
plant   592 FFVVGFVVWILEHRVNSEFTGP-----------PQYQISTMFWFAFSIMVFA-----PRE-RVMS 639

  Fly   628 FEA-----TWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLA 687
            |.|     ||:...:::..||||:|::.||:.::..:..::|                   |:||
plant   640 FTARVVVITWYFIVLVLTQSYTASLSSLLTTQQLNPTETSIK-------------------NVLA 685

  Fly   688 DSNETVYRLAFNLMNNDDPSAYTKDNL----------EGVDRVRKNRGDYMFLMETTTLEYHREQ 742
            ......|:....::.....|.:.:..|          |.:::.....|.....||...:.....|
plant   686 KGGPVAYQRDSFVLGKLRESGFPESRLVPFTSPEKCEELLNKGPSKGGVSAAFMEVPYVRVFLGQ 750

  Fly   743 NC-DLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPD- 805
            .| ..:.|...|....:....|.|:...:::|.||||::|..:...|:..|:||.:.:|   ||
plant   751 YCKKYKMVEVPFDVDGFGFVFPIGSPLVADVSRAILKVAESNKATQLETAWFKNIDKTC---PDP 812

  Fly   806 ---PDATPDMTFEELR-GIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVL 866
               ||..|.::|.:|. ..|..|:........:.:.:|::.   ..::.|:...|.|.:..| :.
plant   813 MNNPDPNPTVSFRKLSLDSFLLLFVAAATVCTLALLKFVIC---FLIQNRIILNDEFYRGKR-MK 873

  Fly   867 CVWNNRKPIVAGTPISSVRTT 887
            .:|.........:.||.||:|
plant   874 EMWLKFMESDGESYISRVRST 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	85/393 (22%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	17/92 (18%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	78/395 (20%)
		Lig_chan	554..828	CDD:278489	63/294 (21%)
GLR2.4	NP_001328410.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070