DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GLR1.4

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	925	Identity:	195/925 - (21%)
Similarity:	330/925 - (35%)	Gaps:	274/925 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ACDLID-NGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH--QMTLNLYPAQ 141
            |.||:. ..|.|:.|..|...:..:|.:...|.:|.|........:...|.|:  |.|.:    .
plant   102 AMDLLQTEQVEALVGGQSLLEAKNLAELGEKTKVPVISSFQVPSSLSLAKYNYFIQATHD----T 162

  Fly   142 AILSKAYADIVQNFGWRKFTIVY-DADDARAAARLQDLL---QLREVHNDVVRVRKFHKDDDFRV 202
            :..:|..|.:..||.||...::| |.||.|.:  :|.|:   |...:|                :
plant   163 SSEAKGIAALFSNFDWRTAVLIYEDDDDWRES--IQPLVGHFQQNAIH----------------I 209

  Fly   203 MWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAAD-------- 259
            .:|:                 |...||.|..:..|......:.:..:..|:.|..|:
plant   210 EYKA-----------------EFSVSSNEECIMKQLRKFKASGIRIFVAHISERIANRLFPCARR 257

  Fly   260 ----NETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQS 320
                .|.:|..:| ||.:.|.....|...    .:.:.::...|..|.|       :.|..|...
plant   258 LGMMEEGYAWILT-ARSMNNFQDTNYLAK----EEMEGVIGFKSYIPLT-------EELHNFTLR 310

  Fly   321 WRNASFFYPDRM--VVPRITCDFAASGGRTWAMGR--YLARL-----------------MKGTSG 364
            |:.:.     |:  ||.|::.....:....|::.|  .:|:|                 .||.||
plant   311 WKRSL-----RLEEVVTRMSVCSIWAHDIAWSLARAAEVAKLPGLSVYDLLEAIPESAKHKGLSG 370

  Fly   365 VNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIG-----IAIWD--------------------- 403
                    .|...|:     .|..:.::.::.||     :.:|:
plant   371 --------DIKFIDK-----KFISDKFEIVNMIGRGERSVGLWNSGSFISNRRRRLSSTKALETI 422

  Fly   404 --PRG-----QITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNL-----TGNALYQGYAV 456
              |.|     :|..|......:||.: ||....|      |.|.:.|.:     ||.....||.:
plant   423 IWPGGSTRIPKIRSLKEKRHGKKKKL-RVLVPAG------NITPQILEVKTDFKTGVTAATGYCI 480

  Fly   457 DLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINN----DAHMGICDLTITQARKT 517
            |:.:.......:|..::|..    |.::  .|.:|.::..:.:.    ||.:|  |:|||..|..
plant   481 DVFETSILPFNYEVEYIPWP----GAIN--YKNYNDLVYTLYSQKDKYDAAVG--DITITDNRSL 537

  Fly   518 AVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWE 582
            .||||:||..:|::::..|    :|::.....|....:|:.| .|.|::|  ..||..|.:.|
plant   538 YVDFTLPFTDMGLAVVTAK----DKSMWIIFKPLTLSLWLTI-ASFFILT--GAIVWLIERHD-- 593

  Fly   583 NPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRM------FEATWWIFAIIIAN 641
                 |.|         ...:.:..:.:::..|...|..:.:.|:      |....||||::|..
plant   594 -----NAD---------FQGSCFQQIGTLLCFGFSTLVFAHRERLQHNMSRFVVIVWIFAVLILT 644

  Fly   642 S-YTANLAAFLTSSKMEG--SIANLKDLSAQ---KKVKFGTIYGGSTYNLLADSNETVYRLAFNL 700
            | |||.|.:.:|..::.|  |..|:...||.   ..|.....:.|..|..|..:::..     |.
plant   645 SNYTATLTSVMTVQQIRGLKSNENIGFFSASIAANVVNDNPTFQGPRYKGLKTADDFT-----NA 704

  Fly   701 MNNDDPSAYTKDNLEGVDR-VRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPF 764
            :.|...| :..|.:..|.. |.|:..::: ::||             .||...||     .|...
plant   705 LRNGTIS-FIVDEVPYVKLFVAKHPSEFV-IVET-------------ESVTNGFG-----FAFQK 749

  Fly   765 GAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEEL-----RGIFYTL 824
            |:.....:|..|.|| .|.|.....:.||       |:.....||.:.||..|     ||:|  :
plant   750 GSPLVQKVSREIEKL-RRTEKLKAIENWW-------FQRQTTSATSEDTFHPLTVYTFRGLF--M 804

  Fly   825 YAGILIAFLIGITEFLVYV-------QQVALEERLTF-KDAFKKEIRFVLCVWNNRKPIVAGTPI 881
            ..|:..||.:     :||:       :||.|:....: ...|.:|||              .:|
plant   805 ITGVSFAFAL-----IVYLIPWNREQRQVVLKHFHRYVSHRFAREIR--------------PSP- 849

  Fly   882 SSVRTTPRRSLDKSL 896
                |||.|..:.|:
plant   850 ----TTPNRQNENSV 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	70/391 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	17/104 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	91/392 (23%)
		Lig_chan	554..828	CDD:278489	67/291 (23%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	70/376 (19%)
		ANF_receptor	64..390	CDD:279440	67/356 (19%)
		GluR_Plant	448..778	CDD:270404	92/400 (23%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	51/211 (24%)
		Lig_chan	570..810	CDD:278489	68/293 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060