DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GLR2.7

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	1060	Identity:	221/1060 - (20%)
Similarity:	389/1060 - (36%)	Gaps:	292/1060 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEF----MTVVNAINGP----ESEQTMRFY 61
            :|:.||:.      :::..:|.:|..     |:|...|    :|.:|.....    .|:.|.|..
plant    25 VLMEGCLG------QNQTTEIKVGVV-----LDLHTSFSKLCLTSINISLSDFYKYHSDYTTRLA 78

  Fly    62 PLIKRLKPEDGSVTMQEHACDLIDN-GVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQ 125
            ..| |...|| .|.....|.|||.| .|:||.||.:...::.:..:.:.:.:|.|.|       .
plant    79 IHI-RDSMED-VVQASSAALDLIKNEQVSAIIGPRTSMQAEFMIRLADKSQVPTITF-------S 134

  Fly   126 AEKPNHQMTLNLYPAQAILS-----KAYADIVQNFGWRKFTIVY--------------DADDARA 171
            |..|......:.|..:|.|.     ||.|.||::||||....:|              ||
plant   135 ATCPLLTSINSPYFVRATLDDSSQVKAIAAIVKSFGWRNVVAIYVDNEFGEGILPLLTDA----- 194

  Fly   172 AARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRGERRV-VLDCEPNMLVELLNSSTEFGLT 235
               |||:...  |.|..:..::.:.|...:.::|.:..:.|| |:...|.:.......:.|.|:.
plant   195 ---LQDVQAF--VVNRCLIPQEANDDQILKELYKLMTMQTRVFVVHMPPTLGFRFFQKAREIGMM 254

  Fly   236 GQYNHIFLTNLETYTDHLEELAADNE--TFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYES 298
             :..:::|     .||.:..|...||  :...|:.....:.:..|....|....:........:.
plant   255 -EEGYVWL-----LTDGVMNLLKSNERGSSLENMQGVLGVRSHIPKSKKLKNFRLRWEKMFPKKG 313

  Fly   299 SDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGR------TWAMGRYLAR 357
            :|....:.....:|::...|.:        .::..:..:..|...:.|.      |..:.||...
plant   314 NDEEMNIFALRAYDSITALAMA--------VEKTNIKSLRYDHPIASGNNKTNLGTLGVSRYGPS 370

  Fly   358 LMKGTSGVN-----------NTNFRTSILQFD-----EDGQRITFNIEVYDPLDGI--------- 397
            |:|..|.|.           |....:|:  ||     ...:||   |.::.|.:||
plant   371 LLKALSNVRFNGLAGEFELINGQLESSV--FDVINIIGSEERI---IGLWRPSNGIVNAKSKNTT 430

  Fly   398 -------GIAIWD------PRG-QI----TQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELN 444
                   |..||.      |:| ||    ..|.|.:..:|..:..|..:|.|
plant   431 SVLGERLGPVIWPGKSKDVPKGWQIPTNGKMLRVGIPVKKGFLEFVDAKIDP------------- 482

  Fly   445 LTGNALY-QGYAVDLIDAIARHVGF----EYVFVPVADQQYGKLDKE--TKQWNGIIGEIINNDA 502
             ..||:. .||.:::.:|:.:.:.:    :|:.....|:.|.::..:  |..::.::|
plant   483 -ISNAMTPTGYCIEIFEAVLKKLPYSVIPKYIAFLSPDENYDEMVYQVYTGAYDAVVG------- 539

  Fly   503 HMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMT 567
                 |:||...|...||||:|:.:.|||::.....:  |....:|.|:..::|:   .:.....
plant   540 -----DVTIVANRSLYVDFTLPYTESGVSMMVPLKDN--KNTWVFLRPWSLDLWV---TTACFFV 594

  Fly   568 FLKTIVARISKMDWENPHPCNRD----PEVLENQWRIHNTG---WLTVASIMTAGCDILPRSPQV 625
            |:..||       |...|..|.|    |.        |..|   |...:::..|..:.:. |...
plant   595 FIGFIV-------WILEHRVNTDFRGPPH--------HQIGTSFWFAFSTMNFAHREKVV-SNLA 643

  Fly   626 RMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYG---GSTYNLLA 687
            |.....|....:::..||||||.:|.|...::.::.|.|||     :||....|   |:....|.
plant   644 RFVVLVWCFVVLVLIQSYTANLTSFFTVKLLQPTVTNWKDL-----IKFNKNIGYQRGTFVRELL 703

  Fly   688 DSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVR-KNRG-----DYMFLMETTTLEYHR------ 740
            .|                         :|.|..: |..|     |.:|...|.|..:..
plant   704 KS-------------------------QGFDESQLKPFGSAVECDELFSNGTITASFDEVAYIKV 743

  Fly   741 --EQNCDLRSVGE-KFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFE 802
              .||....::.| .|....:....|..:....::|.|||.:::..|:..::.||:|.|| :|
plant   744 ILSQNSSKYTMVEPSFKTAGFGFVFPKKSPLTDDVSRAILNVTQGEEMQHIENKWFKKPN-NC-- 805

  Fly   803 EPDPDATPDMTFEELR-----GIFYTLYAGI--LIAFLIGITEFLVYVQQVALEERLTFKDAFKK 860
               ||....::...|.     |:|  |.|||  .:|.||.:..||...:....::.   :::|:.
plant   806 ---PDLNTSLSSNHLSLSSFWGLF--LIAGIASFLALLIFVANFLYEHKHTLFDDS---ENSFRG 862

  Fly   861 EIRFVL----------------CVWNNRKPIVAG--TPISSVRTTPRRSLDKSLDRTPKSSRRVV 907
            :::|::                .|.|...||..|  :|::. ::||       |.|:|:..|.:
plant   863 KLKFLVRNFDEKDIKSHMFKENAVHNVSSPITQGSSSPLTD-QSTP-------LPRSPEQYREL- 918

  Fly   908 IGRSSEEMREMAQGSGSSSG 927
                     |:.:.|..|||
plant   919 ---------ELRRVSSISSG 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	91/452 (20%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	11/89 (12%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	82/402 (20%)
		Lig_chan	554..828	CDD:278489	65/303 (21%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361	86/423 (20%)
		ANF_receptor	54..405	CDD:279440	78/385 (20%)
		GluR_Plant	460..799	CDD:270404	84/415 (20%)
		Lig_chan	584..832	CDD:278489	66/304 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.070