DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GLR2.9

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001325277.1	Gene:	GLR2.9 / 817458	AraportID:	AT2G29100	Length:	942	Species:	Arabidopsis thaliana

Alignment Length:	1013	Identity:	211/1013 - (20%)
Similarity:	382/1013 - (37%)	Gaps:	224/1013 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AFFMC----------RSRGQQINIGAFFYDDELELEKEFMTV-VNAINGPESEQTMRFY------ 61
            ::|:|          :::..:|.:|..     |:|...|..: :.:|....|:    ||
plant    11 SYFVCGFLLMGVGLGQNQTSEIKVGVV-----LDLNTTFSKICLTSIKMAVSD----FYADHPNY 66

  Fly    62 ----PLIKRLKPEDGSVTMQEHACDLI-DNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISD 121
                .|..|...|| :|.....|.||| ...|:||.||.:...:|.:..:.|.|.:|.|.|..:.
plant    67 LTRLTLHVRDSMED-TVQASAAALDLIKTEQVSAIIGPINSMQADFMIKLANKTQVPTITFSATS 130

  Fly   122 EGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAAR--LQDLLQLREV 184
            ..:.:.|..:.:...:..:..:  :|.|.|.:.|.||:...:|..::......  |.|.||..||
plant   131 PLLTSIKSPYFVRATIDDSSQV--RAIASIFKFFRWRRVVAIYVDNEFGEGFMPFLFDALQDVEV 193

  Fly   185 HNDVVRVRKFHKDDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLE 247
            ...|:.....  ||:.:...:.:  |..|..|:..|.::.:.:...:.:.|:..:.....:||..
plant   194 KRSVIPPEAI--DDEIQKELRKLMERQARVFVVHMESSLALRVFQIARDIGMMEEGYVWLMTNGM 256

  Fly   248 TY-TDHLEELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDL-- 309
            |: ..|:      |...::|.....|.|....|. |...|....|....:|..:|  ::..||
plant   257 THMMRHI------NNGRSLNTIEGVLGVRSHVPK-SKELGDFRLRWKRTFEKENP--SMRDDLNV 312

  Fly   310 ----IHDALQLFAQSWRNA---SFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGTSGVNN 367
                .:|::...|::...|   |.:|.:...:.:...|....|     :..|...|.|..|.|..
plant   313 FALWAYDSITALAKAVEKANTKSLWYDNGSTLSKNRTDLGNVG-----VSLYGPSLQKAFSEVRF 372

  Fly   368 TNF--------------RTSILQFDEDGQRITFNIEVYDPLDG-----------IGIAIWDPRGQ 407
            ...              :..|:.|..:.:||   |..:.|.||           :|..||..:.:
plant   373 NGLAGEFKLIDGQLQSPKFEIINFVGNEERI---IGFWTPRDGLMDATSSNKKTLGPVIWPGKSK 434

  Fly   408 ITQLNVDVKAQKKMIYRVATRIGPP----YFSYNETARELN-LTGNALYQGYAVDLIDA------ 461
            |.....::..:|       .|:|.|    :|.:.:..  :| :|......|||:::.:|
plant   435 IVPKGWEIPGKK-------LRVGVPMKKGFFDFVKVT--INPITNKKTPTGYAIEIFEAALKELP 490

  Fly   462 ---IARHVGFEYVFVPVADQQYGKLDKET--KQWNGIIGEIINNDAHMGICDLTITQARKTAVDF 521
               |..:|.||      :...|..|..:.  |.|:.::|            |:|||..|....||
plant   491 YLVIPEYVSFE------SPNNYNNLVYQVYDKTWDAVVG------------DITITANRSLYADF 537

  Fly   522 TVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHP 586
            |:||.:.|||::.....:..|....:|.|:..|  :|:....| ..|:..:|       |...|.
plant   538 TLPFTESGVSMMVPVRDNENKDTWVFLEPWSLE--LWVTTGCF-FVFIGFVV-------WLFEHR 592

  Fly   587 CNRD---PEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLA 648
            .|.|   |.    |::|..:.|.:.::::.|..:.:. |...|.....|....:::..||||:|.
plant   593 VNTDFRGPP----QYQIGTSLWFSFSTMVFAHRENVV-SNLARFVVVVWCFVVLVLTQSYTASLT 652

  Fly   649 AFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDN 713
            :|||...::.::.|:.||...:..   ..|.|..:     ..:.:..|.|:           :|.
plant   653 SFLTVQSLQPTVTNVNDLIKNRDC---VGYQGGAF-----VKDILLGLGFH-----------EDQ 698

  Fly   714 LEGVDRVR---------KNRGDYMFLMETTTLEYHREQNCDLRSVGE-KFGEKHYAIAVPFGAEY 768
            |:..|..:         |::|......|...|:....|:|....:.| .|....:..|.|..:..
plant   699 LKPFDSAKDADDLLSKGKSKGIAAAFDEVAYLKAILSQSCSKYVMVEPTFKTGGFGFAFPKNSPL 763

  Fly   769 RSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPD---ATPDMTFEELRGIFYTLYAGILI 830
            ....|.|||.|::......::.:|:...| .|   |||.   ::..:......|:|  |.||..|
plant   764 TGEFSRAILNLTQNNVTQQIEDRWFPKKN-DC---PDPMTALSSNRLNLSSFLGLF--LIAGTAI 822

  Fly   831 AFLIGITEFLVYVQQVALEERLTF----KDAFKKEIRFVLCVWNNR----------------KPI 875
            :|     ..||:|.....|.|.|.    :|:..::::|:..:::.:                .|:
plant   823 SF-----SLLVFVALFLYEHRHTLGDDSEDSLWRKLKFLFKIFDEKDMNSHTFKNSAIHNISSPM 882

  Fly   876 VAGTPI-SSVRTTPRRSLDKSLDRTPKSSRRVVIGRSS 912
            ...||. |:|:.||       ..::|..:|...:.|.|
plant   883 THKTPSPSTVQITP-------WPQSPSQNREFELRRVS 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	89/428 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/92 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	86/399 (22%)
		Lig_chan	554..828	CDD:278489	60/289 (21%)
GLR2.9	NP_001325277.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.070