DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GLR2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001318239.1	Gene:	GLR2 / 816231	AraportID:	AT2G17260	Length:	925	Species:	Arabidopsis thaliana

Alignment Length:	968	Identity:	198/968 - (20%)
Similarity:	338/968 - (34%)	Gaps:	288/968 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQ-AEKPNHQMTLNLYPAQAI 143
            |...::..|.||.||.:...:.:::.:.|...:|.:.|...|..:. .:.|....|.   |:...
plant    91 ALQFMETDVVAIIGPQTSIMAHVLSHLANELTVPMLSFTALDPTLSPLQFPFFVQTA---PSDLF 152

  Fly   144 LSKAYADIVQNFGWRKFTIVYDADD--ARAAARLQDLLQLR--------------------EVHN 186
            |.:|.|:::..:||.....:|:.||  ......|.|.|:.|                    |:..
plant   153 LMRAIAEMITYYGWSDVVALYNDDDNSRNGVTALGDELEERRCKISYKAVLPLDVVITSPVEIIE 217

  Fly   187 DVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQ-YNHIFLTNLETYT 250
            :::::|...              .|.:|::..||....:...:...|:..: |..|..|.|.:..
plant   218 ELIKIRGME--------------SRVIVVNTFPNTGKMIFKEAERLGMMEKGYVWIATTWLSSVL 268

  Fly   251 DHLEELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQ 315
            |  ..|..|  |..||......|..||..         .:||
plant   269 D--SNLPLD--TKLVNGVLTLRLHTPDSR---------KKRD----------------------- 297

  Fly   316 LFAQSWRN-------------ASFFYPDRMVVPRITCDFAASGG-----RTWAMGRY-------- 354
             ||..|:|             ..:.|....::.|.......:||     ....:|..
plant   298 -FAARWKNKLSNNKTIGLNVYGLYAYDTVWIIARAVKTLLEAGGNLSFSNDAKLGSLKGEALNLS 361

  Fly   355 -LARLMKGT-----------SGVNNTNFRTSILQFDEDGQRITFNIEVYDPLD------------ 395
             |:|..:|:           ||:      |..:||..|...:..:.::.:.:|
plant   362 ALSRFDQGSQLLDYIVHTKMSGL------TGPVQFHPDRSMLQPSYDIINLVDDRVHQIGYWSNY 420

  Fly   396 -GIGI----------------------AIW------DPRGQITQLNVDVKAQKKMIYRVATRIG- 430
             |:.|                      ..|      .|||.|.:.|     .:::      |||
plant   421 SGLSIVPPESFYSKPPNRSSSNQHLNSVTWPGGTSVTPRGWIFRNN-----GRRL------RIGV 474

  Fly   431 PPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGF----EYVFVPVADQQYGKLDKETK-QW 490
            |...|:.:....:|.:.|.: |||.:|:.:|..:.:.:    |::|       :|  |..|. .:
plant   475 PDRASFKDFVSRVNGSSNKV-QGYCIDVFEAAVKLLSYPVPHEFIF-------FG--DGLTNPNY 529

  Fly   491 NGIIGEI---INNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFG 552
            |.::.::   ::.||.:|  |:.|...|...||||.|:::.|:.::| ....:.:...|:|.||.
plant   530 NELVNKVTTGVDFDAVVG--DIAIVTKRTRIVDFTQPYIESGLVVVA-PVTRLNENPWAFLRPFT 591

  Fly   553 GEVWIWILISVFVMTFLKTIVARISKMDWENPHPCN---RDP---EVLENQWRIHNTGWLT--VA 609
            ..:|. :..|.||:         :....|...|..|   |.|   :::...|...:|.:.:  ..
plant   592 LPMWA-VTASFFVI---------VGAAIWILEHRINDEFRGPPRRQIITILWFTFSTMFFSHRET 646

  Fly   610 SIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDL-SAQKKVK 673
            ::.|.|          ||....|....:||.:||||:|.:.||..::...|..:..| |:..::.
plant   647 TVSTLG----------RMVLLIWLFVVLIITSSYTASLTSILTVQQLNSPIKGVDTLISSTGRIG 701

  Fly   674 FGTIYGGSTYNLLADS-NETVYRLA--------FNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMF 729
            |..  |....|.:.|. |....||.        .|.:.|...:|.. |....:|         :|
plant   702 FQV--GSFAENYMTDELNIASSRLVPLASPEEYANALQNGTVAAIV-DERPYID---------LF 754

  Fly   730 LMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK 794
            |.:          .|.....|::|....:..|.|..:....::|.|||.|||.|||..:..:|..
plant   755 LSD----------YCKFAIRGQEFTRCGWGFAFPRDSPLAVDMSTAILGLSETGELQKIHDRWLS 809

  Fly   795 NPNASCFEEPDPDATPDMTFEELR-----GIFYTLYAGILIAFLIG----ITEFLVYVQQVALEE 850
            ..|.|     .|..:.....|:|.     |:|..:....|:|..|.    |.:|.....:|.:||
plant   810 KSNCS-----SPHGSQSGDSEQLNVHSFWGMFLVVGIACLVALFIHFFKIIRDFCKDTPEVVVEE 869

  Fly   851 --------RLT-------FKDAFKKEI-RFVLCVWNNRKPIVAGTPISSVRTTPRRSL 892
                    |||       |.|..::|. |.:....||...:.|.:.||  ||..||.:
plant   870 AIPSPKSSRLTKLQTFLAFVDEKEEETKRRLKRKRNNDHSMNANSIIS--RTASRRPI 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	69/426 (16%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	14/121 (12%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	93/397 (23%)
		Lig_chan	554..828	CDD:278489	65/296 (22%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	67/392 (17%)
		GluR_Plant	468..808	CDD:270404	92/400 (23%)
		Lig_chan	594..843	CDD:306551	65/295 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020