DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Grid2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_077355.2	Gene:	Grid2 / 79220	RGDID:	68368	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	244/972 - (25%)
Similarity:	412/972 - (42%)	Gaps:	184/972 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKP 69
            :..|...||..:...:....|:|||.|.:...:.::.|.|.|..:|  ::|:.::...:...:..
  Rat     7 LFFLSFWWSRTWDLATSDSIIHIGAIFDESAKKDDEVFRTAVGDLN--QNEEILQTEKITFSVTF 69

  Fly    70 EDGSVTMQ--EHACDLIDNGVAAIFGPSSKAASDIVALVCNSTG----------IPHIEFDISDE 122
            .||:...|  :.||:|::.|:.|:          :.::.|.|.|          |||:....|..
  Rat    70 VDGNNPFQAVQEACELMNQGILAL----------VSSIGCTSAGSLQSLADAMHIPHLFIQRSTA 124

  Fly   123 -------GIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDAD-DARAAARLQDLL 179
                   |:.....|...||::.| ...|::....:|..:.|:||.|.||:: |.|......|.:
  Rat   125 GTPRSGCGLTRSNRNDDYTLSVRP-PVYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKV 188

  Fly   180 Q-------LREVHN----------DVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLN 227
            .       |::|.|          |.:|:.:.::..|..         ||.:|...|......::
  Rat   189 SQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTL---------RRAILVMNPATAKSFIS 244

  Fly   228 SSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLV--NPDPPPYSLPYGYVTQ 290
            ...|..|.....|..:.|.|.....::||        |..:..||.:  ...|.|.::.......
  Rat   245 EVVETNLVAFDCHWIIINEEINDVDVQEL--------VRRSIGRLTIIRQTFPVPQNISQRCFRG 301

  Fly   291 RDNIVYESSDPPRTLIHDL------IHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTW 349
            ...|.....||......::      |:|.:.|.|.::...   ..||......:........:.|
  Rat   302 NHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKK---LEDRKWHSMASLSCIRKNSKPW 363

  Fly   350 AMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEV----YDPLDGIGI---AIWDPRGQ 407
            ..||.:...:| ..|||..   |..|:|.|:|.....:.|:    |....|.|:   ..|:|
  Rat   364 QGGRSMLETIK-KGGVNGL---TGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNP--- 421

  Fly   408 ITQLN---VDVKAQKKM---IYRVATRIGPPYFSYNETARELNLTGN-ALYQGYAVDLIDAIARH 465
            :|.||   .|.|.:..|   :.||.|.:..|:...:|     |:.|. ..|||:::|::||::.:
  Rat   422 VTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSE-----NVLGKPKKYQGFSIDVLDALSNY 481

  Fly   466 VGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGV 530
            :||.|......|.:||. .:|...|||::||::...|.:||..||||..|:..||||..:|...|
  Rat   482 LGFNYEIYVAPDHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSV 545

  Fly   531 SILAYKSPHVEKTLD--AYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEV 593
            .:|..::   |||:|  |.||||...:|..|..:|.::..|      :..::|.||      |.:
  Rat   546 GVLLRRA---EKTVDMFACLAPFDLSLWACIAGTVLLVGLL------VYLLNWLNP------PRL 595

  Fly   594 LENQW---RIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSK 655
            .....   .::|:.|....|.:..|.::...:...||....||:||:|:.:|||||||||||.::
  Rat   596 QMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITR 660

  Fly   656 MEGSIANLKDLSAQKKVKFGTIYGGSTY------NLLADSNETVYRLAFNLMNNDDPSAYTKDNL 714
            :|.||.:|:|||.|..:.:||:...:.|      .|.....:::|...:.::|..:.|   ::|:
  Rat   661 IESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGS---ENNV 722

  Fly   715 ----EGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLS 773
                .|:.:|:  .|:|.|:.:...|||  ..:.:|...:||....::.|.||:..|:.||...|
  Rat   723 LESQAGIQKVK--YGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFS 785

  Fly   774 VAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPD---MTFEELRGIFYTLYAGILIAFLIG 835
            ..||:|.:.|::..||.|||.. |..|......||...   :..:.|.|:|..|.|||:::.||.
  Rat   786 QRILELQQSGDMDILKHKWWPK-NGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIA 849

  Fly   836 ITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLD 897
            :.|              |:              |:.||    |:.:      |.:..||.:|
  Rat   850 VLE--------------TW--------------WSRRK----GSRV------PSKEDDKEID 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	88/429 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	14/89 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	121/388 (31%)
		Lig_chan	554..828	CDD:278489	82/291 (28%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		70/353 (20%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:415822	92/440 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	121/391 (31%)
		Interaction with AP4M1. /evidence=ECO:0000269\|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349711
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840