DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Grid1

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_077354.1	Gene:	Grid1 / 79219	RGDID:	68366	Length:	1009	Species:	Rattus norvegicus

Alignment Length:	910	Identity:	221/910 - (24%)
Similarity:	388/910 - (42%)	Gaps:	145/910 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MWSAFFMCRS---RGQQ-INIGAFFYDDELELEKEFMTVVNAIN-GPESEQTMRFYPLIKRLKPE 70
            :|...::|:.   |... |:|||.|.::..:.::.|...|:.:: ..:..|:.:....||.::..
  Rat     6 LWLLPWICQCVTVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEAN 70

  Fly    71 DGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTL 135
            :....:|| ||||:..|:.|:...:..|:::.:..:.::..|||:....:..|    .|.....|
  Rat    71 NPFQAVQE-ACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGG----SPRTACHL 130

  Fly   136 NLYP---AQAILSK-------AYADIVQNFGWRKFTIVYDAD-DARA-------AARLQDLLQLR 182
            |..|   |..:.|:       ....:|....|:||.:.||:: |.|.       |:||...:.|:
  Rat   131 NPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQ 195

  Fly   183 EVHNDVVRVRKFHKDDDFRVMWKSIRGE---------RRVVLDCEPNMLVELLNSSTEFGLTGQY 238
            :|..::..|        |..::.:::.|         ||.:|...|......:|.:.|..|..:.
  Rat   196 KVDKNISHV--------FTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKD 252

  Fly   239 NHIFLTNLETYTDHLEEL-----------------AADNE-TFAVNITAARLLVNPDPPPYSLPY 285
            :|....|.|.....:.:|                 |.||: ....|...:.||.:|..
  Rat   253 SHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQE------- 310

  Fly   286 GY--VTQRDNI-VYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGR 347
            ||  :.|..|: :|:|........|..:.|      :.|.:          :..:.|  .....:
  Rat   311 GYLQMLQISNLYLYDSVLMLANAFHRKLED------RKWHS----------MASLNC--IRKSTK 357

  Fly   348 TWAMGR-YLARLMKG-TSGVNNTNFRTSILQFDEDGQRITFNIEV----YDPLDGIG---IAIWD 403
            .|..|| .|..:.|| .:|:      |.:::|.||........|:    |....|..   :|.||
  Rat   358 PWNGGRSMLDTIKKGHITGL------TGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWD 416

  Fly   404 P----RGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGN-ALYQGYAVDLIDAIA 463
            .    .|.:.:..:..:.| .:..:|.|.:..|:....|     |:.|. ..|:|:::|::||:|
  Rat   417 SEKGLNGSLQERPMGSRLQ-GLTLKVVTVLEEPFVMVAE-----NILGQPKRYKGFSIDVLDALA 475

  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528
            :.:||:|......|.:||.....| .|||:|||:|:..|.:.|..:|||..|::.|||:..:|..
  Rat   476 KALGFKYEIYQAPDGRYGHQLHNT-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDY 539

  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWEN---PHPCNRD 590
            .|.|| .|.|..:.::.:..|||...||..|..::.|:..|..::.||..:..::   |.|
  Rat   540 SVGIL-IKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRP---- 599

  Fly   591 PEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSK 655
                .....:|:..|:...:.:..|.:....|..:|:...:||:|.:|:.:|||||||||||.|:
  Rat   600 ----SASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660

  Fly   656 MEGSIANLKDLSAQKKVKFGTIYGGSTYNLL-------ADSNETVYRLAFNLMNNDDPSAYTKDN 713
            |:..:...:|||.|.::.:||:...:.|...       .:.:.|...|...:..|........:.
  Rat   661 MDSPVRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNP 725

  Fly   714 LEGVDRVRKNRGDYMFLMETTTLEYH--REQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAI 776
            .||:.:.:|  |:|.||.:...:||.  .:.:|.:..:|.....|.|.||:..|:.||...|..|
  Rat   726 SEGIRKAKK--GNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRI 788

  Fly   777 LKLSERGELYDLKQKWWKNPNASCFEEPDPDATPD---MTFEELRGIFYTLYAGILIAFLIGITE 838
            |:|.:.|:|..||||||.: ...|.......|..|   :......|:|..|..|:|:|.|:...|
  Rat   789 LELQDTGDLDVLKQKWWPH-TGRCDLTSHSSAQTDGKSLKLHSFAGVFCILAIGLLLACLVAALE 852

Fly 839 838
Rat 853 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	88/435 (20%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	16/88 (18%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	114/383 (30%)
		Lig_chan	554..828	CDD:278489	77/288 (27%)
Grid1	NP_077354.1	Interaction with CBLN1. /evidence=ECO:0000250\|UniProtKB:Q61627	21..436		92/459 (20%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	89/441 (20%)
		ANF_receptor	41..400	CDD:279440	80/402 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	114/386 (30%)
		Lig_chan	564..841	CDD:278489	77/287 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910