DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and grin3ba

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	990	Identity:	200/990 - (20%)
Similarity:	346/990 - (34%)	Gaps:	253/990 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 DLIDNGVAAIFG-PSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH-QMTLNLYPAQAIL 144
            |::..||:|:.. |.|......|..:.:...||.|......|.::.:...| ||...:.|:.  |
Zfish   105 DIVVQGVSAVLAFPQSHEELIQVEFMSSFLEIPFISIIEQGEPLKTQNRFHLQMMTRMPPSG--L 167

  Fly   145 SKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRG 209
            |.....::...||                                                  :|
Zfish   168 SDLLLAVLLRGGW--------------------------------------------------QG 182

  Fly   210 ERRVVLDCEPNM-LVELLNSSTEFGLTGQYNHIFLT-NLETYTDHLEE----------------- 255
            ....|.....|. ::|.|......||.|.:.|::.| ||....:::.|
Zfish   183 GAATVCPGGGNTGMLEELQQRGHLGLDGAHWHLWETLNLSRLEENISEDKVMELLSQLLSRTPSA 247

  Fly   256 -------LAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPP----------R 303
                   ..:|.|..|..:..|..|....||.:.: .||....|::  .|...|          |
Zfish   248 PASSVVLFGSDPECTATVLHCAHQLSGTLPPMHWI-MGYPLSLDSL--HSIGSPLGLMAYGEVNR 309

  Fly   304 TLIHDLIHDALQLFAQSWRNASFFYPDRMVVPR-ITCDFAASGGRTWAMGRYLARLMKGTSGVNN 367
            ..::..|.|.|||..::...|:...||..::.. :.|....:.....:.|:||||.:..||....
Zfish   310 KPLNFYIRDTLQLIGRAVYAATMVRPDLALIQNMVNCFDKPNKHELPSSGQYLARFLSNTSFTGL 374

  Fly   368 T----------------NFRTSILQFDEDGQ------------RITF-------NIEVYDPLDGI 397
            |                .|....||.|..||            |:..       .:..:...||.
Zfish   375 TGPVRVERSFSRVLTSQRFHIWSLQRDPLGQPSWVTVASWQSGRLELEEQGLWPGVTQHQREDGP 439

  Fly   398 GIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPY-FS-------------------------Y 436
            ||.:    |...|..:.|...:   .||.|.:..|: |:                         .
Zfish   440 GIRL----GGRWQAGLPVAGSR---LRVVTLVEHPFVFTREVDEEGQCPAGQLCLDPQTNNSEVL 497

  Fly   437 NETARELNLTGNA--------LYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGI 493
            |:..|||..|.::        ...||.:||::.:|..:.||:....|.|.:||..  :..:|:|:
Zfish   498 NQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFEFDLYIVGDGKYGAW--KGGRWSGL 560

  Fly   494 IGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIW 558
            :|::::..|.|.:...:|..||...:|||.||....:.||. :|......:.|::.|....:|:.
Zfish   561 VGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSLGILV-RSKDTAAPIGAFMWPLHWSMWVG 624

  Fly   559 ILISVFVMTFLKTIVARISKMDWENPH---PCNRDPEVLENQWRIHN-TGWLTVASIMTAGCDIL 619
            |.:::.:.....|:      .:|.:|.   |..|      |:.|:.: :..|.:...:..|..:.
Zfish   625 IFVALHITALFITL------YEWNSPFGMTPHGR------NRIRVFSYSSALNLCYAILFGRTVA 677

  Fly   620 PRSPQV---RMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKK---VKFGTIY 678
            .::|:.   |.....|.||.:::.:||||||||.:...|....::.:.|:.....   .:|||:.
Zfish   678 SKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVKLHHPSLGFRFGTVR 742

  Fly   679 GGSTYNLLADSNETV--YRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYH-- 739
            ..|..:.:..|...:  |...||.....|..:..|.:...:|         .|:|:...|:|.
Zfish   743 ESSAEDYVKKSFPEMHEYMRRFNKPTTPDGVSTLKTDPPQLD---------AFIMDKALLDYEVS 798

  Fly   740 REQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK----NPNASC 800
            .:.:|.|.:||:.|..:.|.|.:|..:....|:|..:.:....|.:..|..||:|    ......
Zfish   799 IDADCKLLTVGKPFAIEGYGIGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDKWYKVVPCGKRVFA 863

  Fly   801 FEEPDPDATPDMTFEELRGIFYTLYAGILIAF--LIGITEFLVYV-----------------QQV 846
            ..|     |..|..:...|:|..|..|:..|.  |:|...|..::                 |::
Zfish   864 VTE-----TLQMGIQHFSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRHQQRFKYWLHTSQKI 923

  Fly   847 ALEERLTFKDAFKKEIRF-----VLCVWNN----RKPIVAGTPISSVRTTPRRSLDKSLDRTPKS 902
            .....:...|..|.|...     .||:..|    |.|..:.:|.|:..|        |...|..:
Zfish   924 HRAINMGCDDERKSEAESSDRCPTLCLSENCNLHRLPPSSSSPPSTSST--------STTTTKWN 980

  Fly   903 SRRVVIGRSSEEMRE 917
            ::.|..||.::|..:
Zfish   981 NQSVKAGREAKEQNK 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	73/395 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	21/94 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	94/418 (22%)
		Lig_chan	554..828	CDD:278489	62/291 (21%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	69/377 (18%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	93/421 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591059
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840