DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIC and grik1b

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_690040.5	Gene:	grik1b / 561540	ZFINID:	ZDB-GENE-070821-1	Length:	906	Species:	Danio rerio

Alignment Length:	903	Identity:	266/903 - (29%)
Similarity:	444/903 - (49%)	Gaps:	106/903 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SRGQQINIGAFFYDDELE----LEKEFMTVVNAINGPES--EQTMRFYPLIKRLKPEDGSVTMQE 78
            |..|.:.||..|...|.|    .|..|...|..||...:  ..|...|. |:|:...| |.....
Zfish    59 SAQQVLRIGGIFETLENEPISVEELAFKFAVTNINRNRTLMPNTTLTYD-IQRINLFD-SFEASR 121

  Fly    79 HACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAI 143
            .|||.:..||||:||||..::...|..:||:..:|||:.......:..:   ....:||||..|.
Zfish   122 RACDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNK---DSFYINLYPDYAS 183

  Fly   144 LSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHK-DDDFRVMWKSI 207
            :|:|..||||.:.|:..|:||  :||....|||:|::....::..:::|:... ..|.|.:.|.:
Zfish   184 ISRAVLDIVQFYKWKAVTVVY--EDATGLIRLQELIKAPSRYSIKIKIRQLPTGSKDARPLLKEM 246

  Fly   208 RGERR--VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAA 270
            :..:.  |:.||......::|......|:..:|.|.|.|.|:.|:..||.....    .||:|..
Zfish   247 KKGKEFCVIFDCSYQTAADVLKQLLSMGMMTEYYHFFFTTLDLYSLDLEPFRYS----GVNMTGF 307

  Fly   271 RLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHD--------LIHDALQLFAQSWRNASFF 327
            |||...:|...|:...:..:|    .::...|.|.:.|        |::||:.:.|.:.:.||
Zfish   308 RLLNIDNPQVASVVEKWSMER----LQAPPKPETGLQDGMMTTEAALMYDAVYMVAAASQRAS-- 366

  Fly   328 YPDRMVVPRITCDFAASGGRTWAMGRYLARLMK-----GTSG---VNNT-----NFRTSILQFDE 379
               ::.|..:.|    ...:.|..|.....:.|     |.:|   :|.|     :|...|:...|
Zfish   367 ---QITVSSLQC----HRHKPWRFGSRFISMFKEAQWNGLTGQIIINKTDGLRKDFDLDIISLKE 424

  Fly   380 DGQRITFNIEVYDPLDGIG--------IAIWDPRGQITQLNV------------DVKAQKKMIYR 424
            ||        :..||:. |        |.:|:..   |.||:            |..|.:.:|
Zfish   425 DG--------LEKPLES-GRFNKVWKKIGVWNSN---TGLNLTDSNKDKNTNVTDSMANRTLI-- 475

  Fly   425 VATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQ 489
            |.|.:..||..|.::.:.  |.||..::||.:||:..::..:||.|....|.|.:|| ...:..:
Zfish   476 VTTILENPYVMYKKSDKP--LYGNDRFEGYCLDLLKELSNILGFSYEVKLVTDGKYG-AQNDKGE 537

  Fly   490 WNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGE 554
            |||::.|:|::.|.:.:..||||..|:..:||:.|||.||:|||.:|.......:.::|.|...:
Zfish   538 WNGMVRELIDHVADLAVAPLTITYVREKVIDFSKPFMTLGISILYHKPNGTNPGVFSFLNPLSPD 602

  Fly   555 VWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDIL 619
            :|:::|::...::.:..::||.:..:|.||||||.|.:|:||.:.:.|:.|..|.::|..|.:::
Zfish   603 IWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLINSVWFGVGALMQQGSELM 667

  Fly   620 PRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYN 684
            |::...|:....||.|.:||.:|||||||||||..:|:..|.:..||:.|.|:::|.:..|||..
Zfish   668 PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTKIEYGAVRDGSTMT 732

  Fly   685 LLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSV 749
            ....|..:.|...:..|::...:|..|:|.||:.||...  ||..|||:|::||..::||:|..:
Zfish   733 FFKKSKISTYEKMWAFMSSRKNTALVKNNREGIQRVLTT--DYALLMESTSIEYISQRNCNLTQI 795

  Fly   750 GEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTF 814
            |.....|.|.:..|.|:.||..:::|||:|.|.|:|:.:|:|||:  ...|.||...:|:. :..
Zfish   796 GGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWR--GNGCPEEDSKEASA-LGV 857

  Fly   815 EELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNR 872
            |.:.|||..|.||::::..:.|.|| :|..:         |:...:|:....|.|:|:
Zfish   858 ENIGGIFIVLAAGLVLSVFVAIGEF-IYKSR---------KNLDIEEVSVGQCEWHNK 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	108/415 (26%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	17/96 (18%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	129/370 (35%)
		Lig_chan	554..828	CDD:278489	97/273 (36%)
grik1b	XP_690040.5	Periplasmic_Binding_Protein_Type_1	62..455	CDD:299141	112/428 (26%)
		ANF_receptor	80..423	CDD:279440	95/366 (26%)
		Periplasmic_Binding_Protein_Type_2	471..840	CDD:304360	130/375 (35%)
		Lig_chan	602..871	CDD:278489	97/273 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.860