Protein Alignment GluRIIC and grin2bb

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001121809.1
• Gene: grin2bb / 559976
• ZFINID: ZDB-GENE-061207-27
• Length: 1770
• Species: Danio rerio
• Alignment Length: 972
• Identity: 214/972 - (22%)
• Similarity: 370/972 - (38%)
• Gaps: 223/972 - (22%)

  Fly    67 LKPEDGSVTMQEHACDLIDNGVAA----------IFGPSS--KAASDIVALVCNSTGIPHIEFDI 119
            |.|:...|||.|.....|.|.:.|          :||..:  :|.:.|:..:...|.||.:....
Zfish   138 LPPKVELVTMNETDPKSIINRICALMSRNWLQGVVFGDDTDQEAIAQILDFISAQTHIPILGIRG 202

  Fly   120 SDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIV---YDADDARAAARLQDLLQL 181
            ....|.|.|.:|.|.....|:....:....:|::.:.|..|:||   |..
Zfish   203 GSSMIMAAKDDHSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYYPG--------------- 252

  Fly   182 REVHNDVVRVRKFHKDDDFRVMWK----------------SIRGERR------VVLDCEPNMLVE 224
               |.|.|...:...|:.| |.|:                .|:.:.:      ::|.|.......
Zfish   253 ---HQDFVNRIRSTVDNSF-VGWELEEVLLLDMSVDDGDSKIQNQMKKLQSPVILLYCTKEEATT 313

  Fly   225 LLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLL-VNPDPPPYSLPYGYV 288
            :...:...|||| |.         ||..:..|.|.:.....|:....|: |:.|...|.|.   .
Zfish   314 IFEVAHSVGLTG-YG---------YTWIVPSLVAGDTDNVPNVFPTGLISVSYDEWDYGLE---A 365

  Fly   289 TQRDNIVYES--------SDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASG 345
            ..||.:...:        ...|.||:....|.|               ||:            .|
Zfish   366 RVRDAVAIIAMATSTMMLDRGPHTLLKSGCHGA---------------PDK------------KG 403

  Fly   346 GRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQR-------ITFNIE-VYDPLD------- 395
            .::......|..||       |..|....|.|.|||.:       |..|.| .|:.:.
Zfish   404 SKSGNPNEVLRYLM-------NVTFEGRNLSFSEDGFQMHPKLVIILLNKERQYERVGKWENGSL 461

  Fly   396 GIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNET--------------AREL--- 443
            .:...:| ||   .:|..|.:.::.....:.|....|:....:.              .::|
Zfish   462 AMKYHVW-PR---FELYSDAEEREDDHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQLKLQ 522

  Fly   444 NLTGNA-LY-----QGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDA 502
            ||||:: :|     :|:.:|::..||:.|.|.|....|.:.::||  |....|||::||::..:|
Zfish   523 NLTGDSGIYIKRCCKGFCIDILKKIAKSVKFTYDLYLVTNGKHGK--KINGTWNGMVGEVVLKNA 585

  Fly   503 HMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMT 567
            ||.:..|||.:.|...:||:|||::.|:|::..:| :...:..|:|.||..:||    :.:|||.
Zfish   586 HMAVGSLTINEERSEVIDFSVPFIETGISVMVSRS-NGTVSPSAFLEPFSADVW----VMMFVML 645

  Fly   568 FLKTIVARISKMDWENPHPCNR----DPEVLENQWRIHNTGWLTVASIMTAGCDIL-PRSPQVRM 627
            .:.:.|| :...::.:|...||    ..|.....:.|....||....:......:. |:....::
Zfish   646 LIVSAVA-VFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKI 709

  Fly   628 FEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQ------KKVKFGTIYGGSTYNLL 686
            ..:.|..||:|...|||||||||:...:....:..|.|...|      ...:|||:..|||
Zfish   710 MVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVTGLSDKKFQHPNDFSPPFRFGTVPNGST---- 770

  Fly   687 ADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSV 749
                |...|..:..|::...|.:.|:..|.:..::..:.| .|:.:...|.|  .|::.|.|.::
Zfish   771 ----ERNIRNNYKEMHSYMTSFHQKNVNEALHSLKSGKLD-AFIYDAAVLNYMAGRDEGCKLVTI 830

  Fly   750 GEK--FGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDM 812
            |..  |....|.||:...:.::..:.:|||:|...||:.:|:..|.   ...|..|.:...:..:
Zfish   831 GSGYIFATTGYGIAIQKDSGWKRAVDLAILQLFGDGEMEELEALWL---TGICHNEKNEVMSSQL 892

  Fly   813 TFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKP--- 874
            ..:.:.|:||.|.|.:.::.:..|.|.|.|.|                 :||......:.||
Zfish   893 DVDNMAGVFYMLGAAMALSLITFIAEHLFYWQ-----------------LRFCFMGVCSGKPGMT 940

  Fly   875 ---------IVAGTPI---SSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGS 924
                     .:.|..|   .|...:|..::..:::.|..:..|::  |:::.|..:...:||
Zfish   941 FSISRGIYSCIHGVQIEENKSALNSPSATMKMNMNNTHSNILRLL--RTAKNMTSVPGVNGS 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	80/402 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	106/408 (26%)
		Lig_chan	554..827	CDD:459656	69/287 (24%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..465	CDD:380601	77/392 (20%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	107/419 (26%)
		NMDAR2_C	919..1770	CDD:463148	17/101 (17%)