Protein Alignment GluRIIC and grik4

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_021322088.1
• Gene: grik4 / 556582
• ZFINID: ZDB-GENE-070821-5
• Length: 965
• Species: Danio rerio
• Alignment Length: 961
• Identity: 262/961 - (27%)
• Similarity: 444/961 - (46%)
• Gaps: 101/961 - (10%)

  Fly     2 WQRILLLGCMWSAFFMCRSRGQQINIGAFFYDDELEL---EKEFMTVV-NAINGPESEQT----- 57
            |..:|.| .||..  ...|......|.|.. ||.:|.   |:..:|:. ::||...:..|
Zfish     5 WAPLLFL-AMWVR--NATSGPLSFRIAAIL-DDPMECSRGERLAITLAKDSINRSSNRSTTGKLE 65

  Fly    58 MRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPS-SKAASDIVALVCNSTGIPHIEFDISD 121
            :..:.|::..:.|.|     |..|.::..||.|:.||| |.|::.|::.:|....:|:::  ::.
Zfish    66 VDIFELLRDSEYETG-----ETMCQIMSKGVVAVLGPSASPASNSIISNICGEKEVPYVK--VAP 123

  Fly   122 EGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN 186
            |.|...:.....||:|.|....:|.|.|.::..|......::  ...|.....|:.||:...:..
Zfish   124 EDILKVQFPRFTTLDLRPTNTDISMAVAGLLTFFNSSTSCLI--CAQADCLLNLEVLLRQFLISK 186

  Fly   187 DVVRVRKFHKDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETY 249
            :.:.||......|...:.|.||.::  .:::|....|...:|..::|.|:...|....||:||..
Zfish   187 ETLSVRMLDDSQDPTPLLKEIRDDKTATIIVDANATMSHVILERASELGMLSVYYTYILTSLEFS 251

  Fly   250 TDHLEELAADNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIVYESSDPPRTLIHDL 309
            ...|::||...    |||....:. |...|.:     ||...:....|:..:..:.....|:.|.
Zfish   252 LLRLDDLADQR----VNIVGFSVF-NRTHPFFQDFVLSLNRSWQENCDHAPFAGTPLSSALLFDA 311

  Fly   310 IHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMG----RYLARL-MKGTSGVNNTN 369
            :|..:....:..|:      ..:...:::|    ...:.|..|    .||..: ::|.:|
Zfish   312 VHTVVAAVQELNRS------QNVGATQLSC----KSSKIWEHGTSLMNYLRMVELEGLTG----- 361

  Fly   370 FRTSILQFDEDGQRITFNIEV-YDPLDGI-GIAIW-DPRG-----QITQLNV-DVKAQKKMIYRV 425
                .::|:..|||..:.:.: .:..||: .|..| ..:|     ::..||| |......:  .:
Zfish   362 ----HIEFNSKGQRSNYALRIMQNSRDGLRQIGQWHSEQGLSMERKLPSLNVTDTLFNTTL--TI 420

  Fly   426 ATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQW 490
            .|.:..||.......:||.  ||..|:|:.||::..:|..:.|:|....|.|..|| :......|
Zfish   421 TTILENPYVMLRANHQELE--GNDRYEGFCVDMLKELADILKFKYRIRLVGDGVYG-VPGANGTW 482

  Fly   491 NGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT--LDAYLAPFGG 553
            .|::||:|:..|.:.:..||||..|:..:||:.|||.||:||: |: .|:.:.  ..::|.||..
Zfish   483 TGMVGELISRKADLAVAALTITAEREKVIDFSKPFMTLGISIM-YR-VHIGRRPGYFSFLDPFSP 545

  Fly   554 EVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDP-EVLENQWRIHNTGWLTVASIMTAGCD 617
            .||:::|::...::.:..:|||::..:|.|||||.:.. .:|.||:.:.|:.|..|...|..|..
Zfish   546 GVWLFMLLAYLAVSCVLFLVARLTPYEWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGST 610

  Fly   618 ILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGST 682
            |.||:...|.....||.|.:||.:|||||||||||..:||..|.::.||:.|..:::||::||||
Zfish   611 IAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGST 675

  Fly   683 YNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLR 747
            .....:|....|:..:|.|.:..||.:.|...||:.||..:  :|.:|:|:|..||:|::||:|.
Zfish   676 MTFFQNSRYQTYQRMWNFMYSKQPSVFVKSTEEGIARVLNS--NYAYLLESTMNEYYRQRNCNLT 738

  Fly   748 SVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDM 812
            .:|.....|.|.|.:|.|:.||....:|||:|.|...|..||:|||  ....|.:|.|..| ..:
Zfish   739 QIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWW--DGGKCPKEEDHRA-KGL 800

  Fly   813 TFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVA 877
            ..|.:.|||..|..|:|:|..:.:.||:..::.....|....::..::....|||.
Zfish   801 GMENIGGIFVVLVCGLLVAIFMAVLEFVWMLRHTPGTELSVCEEMLRELQGIVLCQ--------- 856

  Fly   878 GTPISSVRTTPRRSLDKSLDR---TPKSSRRVVIGRSSEEMREMAQGSGSS 925
                .|::...||.  .|:.|   .|...||.....:|....::..|:|.|
Zfish   857 ----DSLQLRRRRG--ASVLRPQPLPLDERRARAAAASLSNGKLCTGTGLS 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	87/412 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	134/373 (36%)
		Lig_chan	554..827	CDD:459656	101/273 (37%)
grik4	XP_021322088.1	Periplasmic_Binding_Protein_type1	24..401	CDD:471960	87/410 (21%)
		PBP2_iGluR_kainate_KA1	425..785	CDD:270442	134/368 (36%)