DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIC and grik4

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	961	Identity:	262/961 - (27%)
Similarity:	444/961 - (46%)	Gaps:	101/961 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WQRILLLGCMWSAFFMCRSRGQQINIGAFFYDDELEL---EKEFMTVV-NAINGPESEQT----- 57
            |..:|.| .||..  ...|......|.|.. ||.:|.   |:..:|:. ::||...:..|
Zfish     5 WAPLLFL-AMWVR--NATSGPLSFRIAAIL-DDPMECSRGERLAITLAKDSINRSSNRSTTGKLE 65

  Fly    58 MRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPS-SKAASDIVALVCNSTGIPHIEFDISD 121
            :..:.|::..:.|.|     |..|.::..||.|:.||| |.|::.|::.:|....:|:::  ::.
Zfish    66 VDIFELLRDSEYETG-----ETMCQIMSKGVVAVLGPSASPASNSIISNICGEKEVPYVK--VAP 123

  Fly   122 EGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN 186
            |.|...:.....||:|.|....:|.|.|.::..|......::  ...|.....|:.||:...:..
Zfish   124 EDILKVQFPRFTTLDLRPTNTDISMAVAGLLTFFNSSTSCLI--CAQADCLLNLEVLLRQFLISK 186

  Fly   187 DVVRVRKFHKDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETY 249
            :.:.||......|...:.|.||.::  .:::|....|...:|..::|.|:...|....||:||..
Zfish   187 ETLSVRMLDDSQDPTPLLKEIRDDKTATIIVDANATMSHVILERASELGMLSVYYTYILTSLEFS 251

  Fly   250 TDHLEELAADNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIVYESSDPPRTLIHDL 309
            ...|::||...    |||....:. |...|.:     ||...:....|:..:..:.....|:.|.
Zfish   252 LLRLDDLADQR----VNIVGFSVF-NRTHPFFQDFVLSLNRSWQENCDHAPFAGTPLSSALLFDA 311

  Fly   310 IHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMG----RYLARL-MKGTSGVNNTN 369
            :|..:....:..|:      ..:...:::|    ...:.|..|    .||..: ::|.:|
Zfish   312 VHTVVAAVQELNRS------QNVGATQLSC----KSSKIWEHGTSLMNYLRMVELEGLTG----- 361

  Fly   370 FRTSILQFDEDGQRITFNIEV-YDPLDGI-GIAIW-DPRG-----QITQLNV-DVKAQKKMIYRV 425
                .::|:..|||..:.:.: .:..||: .|..| ..:|     ::..||| |......:  .:
Zfish   362 ----HIEFNSKGQRSNYALRIMQNSRDGLRQIGQWHSEQGLSMERKLPSLNVTDTLFNTTL--TI 420

  Fly   426 ATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQW 490
            .|.:..||.......:||.  ||..|:|:.||::..:|..:.|:|....|.|..|| :......|
Zfish   421 TTILENPYVMLRANHQELE--GNDRYEGFCVDMLKELADILKFKYRIRLVGDGVYG-VPGANGTW 482

  Fly   491 NGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT--LDAYLAPFGG 553
            .|::||:|:..|.:.:..||||..|:..:||:.|||.||:||: |: .|:.:.  ..::|.||..
Zfish   483 TGMVGELISRKADLAVAALTITAEREKVIDFSKPFMTLGISIM-YR-VHIGRRPGYFSFLDPFSP 545

  Fly   554 EVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDP-EVLENQWRIHNTGWLTVASIMTAGCD 617
            .||:::|::...::.:..:|||::..:|.|||||.:.. .:|.||:.:.|:.|..|...|..|..
Zfish   546 GVWLFMLLAYLAVSCVLFLVARLTPYEWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGST 610

  Fly   618 ILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGST 682
            |.||:...|.....||.|.:||.:|||||||||||..:||..|.::.||:.|..:::||::||||
Zfish   611 IAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGST 675

  Fly   683 YNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLR 747
            .....:|....|:..:|.|.:..||.:.|...||:.||..:  :|.:|:|:|..||:|::||:|.
Zfish   676 MTFFQNSRYQTYQRMWNFMYSKQPSVFVKSTEEGIARVLNS--NYAYLLESTMNEYYRQRNCNLT 738

  Fly   748 SVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDM 812
            .:|.....|.|.|.:|.|:.||....:|||:|.|...|..||:|||  ....|.:|.|..| ..:
Zfish   739 QIGGLLDTKGYGIGMPLGSVYRDEFDLAILRLQEENRLEILKRKWW--DGGKCPKEEDHRA-KGL 800

  Fly   813 TFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVA 877
            ..|.:.|||..|..|:|:|..:.:.||:..::.....|....::..::....|||.
Zfish   801 GMENIGGIFVVLVCGLLVAIFMAVLEFVWMLRHTPGTELSVCEEMLRELQGIVLCQ--------- 856

  Fly   878 GTPISSVRTTPRRSLDKSLDR---TPKSSRRVVIGRSSEEMREMAQGSGSS 925
                .|::...||.  .|:.|   .|...||.....:|....::..|:|.|
Zfish   857 ----DSLQLRRRRG--ASVLRPQPLPLDERRARAAAASLSNGKLCTGTGLS 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	86/402 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	14/93 (15%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	134/373 (36%)
		Lig_chan	554..828	CDD:278489	101/274 (37%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	87/407 (21%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	134/368 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.960