Protein Alignment GluRIIC and Gria3

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_058582.4
• Gene: Gria3 / 53623
• MGIID: 95810
• Length: 888
• Species: Mus musculus
• Alignment Length: 866
• Identity: 259/866 - (29%)
• Similarity: 411/866 - (47%)
• Gaps: 63/866 - (7%)

  Fly    25 INIGAFFYDDELELEKEFMTVVNAINGPE--SEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNG 87
            |:||..|..:.::....|...|...|..:  :|:.......:..| ....|.::....|.....|
Mouse    28 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHL-DSSNSFSVTNAFCSQFSRG 91

  Fly    88 VAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIV 152
            |.||||...:.:.:.:...|   |..|..|........|:.   |..:.:.||   |..|...::
Mouse    92 VYAIFGFYDQMSMNTLTSFC---GALHTSFVTPSFPTDADV---QFVIQMRPA---LKGAILSLL 147

  Fly   153 QNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFH--KD-DDFRVMWKSI--RGERR 212
            ..:.|.||..:||.:  |..:.||.:::....:|..|..|...  || .:||.:.:.:  |.|:|
Mouse   148 GYYKWEKFVYLYDTE--RGFSILQAIMEAAVQNNWQVTARSVGNIKDIQEFRRIIEEMDRRQEKR 210

  Fly   213 VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPD 277
            .::|||...:..:|......|...:..|..|.|| .:||.:.|.....   ..|||..:::.|.:
Mouse   211 YLIDCEVERINTILEQVVILGKHSRGYHYMLANL-GFTDIVLERVMHG---GANITGFQIVNNEN 271

  Fly   278 PPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPR--ITCD 340
            |........:|...:....|:.:.|......|.|||:.:.|:::|   :....|:.|.|  ...|
Mouse   272 PMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR---YLRRQRVDVSRRGSAGD 333

  Fly   341 FAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYD-PLDGIGIA-IWD 403
            ..|:....|:.|..:.|.:|    :......|..:|||..|:|..:.|:||: .:.|...| .|:
Mouse   334 CLANPAVPWSQGIDIERALK----MVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWN 394

  Fly   404 PRGQIT-----QLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIA 463
            ...:..     |::.|..:.:.....|.|.:..||..|.:...:|.  ||..|:||.|||...||
Mouse   395 EYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLE--GNERYEGYCVDLAYEIA 457

  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528
            :||..:|....|.|.:||..|.|||.|||::||::...|.:.:..||||..|:..:||:.|||.|
Mouse   458 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL 522

  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDW----ENPHP 586
            |:||:..|....:..:.::|.|...|:|:.|:   |.|.|:.||   |:|.|..:|    .|..|
Mouse   523 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHLEDNNEEP 584

  Fly   587 CNRDPEV---LENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLA 648
              |||:.   ..|::.|.|:.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||
Mouse   585 --RDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 647

  Fly   649 AFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDN 713
            ||||..:|...|.:.:||:.|.::.:||:..|||......|...||...::.|.:.:||.:||..
Mouse   648 AFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT 712

  Fly   714 LEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAIL 777
            .:||.||||::|.:.||:|:|..|| .:.:.||...||.....|.|.:|.|.|:..|:.:::|:|
Mouse   713 ADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVL 777

  Fly   778 KLSERGELYDLKQKWWKNP-NASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLV 841
            ||||:|.|..||.|||.:. .....:....|.|..::...:.|:||.|..|:.:|.::.:.||..
Mouse   778 KLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 842

  Fly   842 YVQQVALEERLT-----FKDA 857
            ..:..:...:||     ||.|
Mouse   843 KSRAESKRMKLTKNTQNFKPA 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	91/393 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	149/381 (39%)
		Lig_chan	554..827	CDD:459656	106/284 (37%)
Gria3	NP_058582.4	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	91/396 (23%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	150/389 (39%)