DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIIC and Gria1

DIOPT Version :9

Sequence 1:NP_608557.4 Gene:GluRIIC / 33275 FlyBaseID:FBgn0046113 Length:940 Species:Drosophila melanogaster
Sequence 2:NP_113796.1 Gene:Gria1 / 50592 RGDID:621531 Length:907 Species:Rattus norvegicus


Alignment Length:957 Identity:265/957 - (27%)
Similarity:428/957 - (44%) Gaps:122/957 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDG 72
            ||.:..|.|     ...|.||..|.:.:.:....|...::.:..|.     :..|.|..:...| 
  Rat    13 LGAVVGANF-----PNNIQIGGLFPNQQSQEHAAFRFALSQLTEPP-----KLLPQIDIVNISD- 66

  Fly    73 SVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGI----PHIEFDISDEGIQAEKPNHQM 133
            |..|....|.....||.||||...:...:::...|.:..:    |....|.|          :|.
  Rat    67 SFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTS----------NQF 121

  Fly   134 TLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN-DVVRVRKF-HK 196
            .|.|.|.   |.:|...|:.::.|:.|..:||||  |..:.||.:|......| .|..|... ..
  Rat   122 VLQLRPE---LQEALISIIDHYKWQTFVYIYDAD--RGLSVLQRVLDTAAEKNWQVTAVNILTTT 181

  Fly   197 DDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAAD 259
            ::.:|::::.:  :.||.||:|||...|..:|....:....|...|..|.||......|.:.   
  Rat   182 EEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKF--- 243

  Fly   260 NETFAVNITAARLLVNPDPPPYSLPYGYVT--QRDNIVYESSDPPRTLIHDLIHDALQLFAQSWR 322
             :....|:|..:|:...|..|..:...:.|  .||:...:...|..|  ..|.:|.:::.|::::
  Rat   244 -KESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYT--SALTYDGVKVMAEAFQ 305

  Fly   323 NASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFR--TSILQFDEDGQR 383
            :   ....|:.:.|  ...|..|:....|..|..:.|.::      ...|.  |..:||:|.|:|
  Rat   306 S---LRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQ------QVRFEGLTGNVQFNEKGRR 361

  Fly   384 ITFNIEVYD-PLDGI-GIAIWD------PRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETA 440
            ..:.:.|.: ..||| .|..|:      |.....|...|..:.:...|.|.|.:..||....:.|
  Rat   362 TNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNA 426

  Fly   441 RELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMG 505
            .:..  ||..|:||.|:|...||:|||:.|....|:|.:||..|.:||.|||::||::...|.:.
  Rat   427 NQFE--GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVA 489

  Fly   506 ICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMT 567
            :..||||..|:..:||:.|||.||:||:..|....:..:.::|.|...|:|:.|:   |.|.|:.
  Rat   490 VAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVL 554

  Fly   568 FLKTIVARISKMDWENPH-PCNRDPEVLE--NQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFE 629
            ||   |:|.|..:|.:.. ...||....:  |::.|.|:.|.::.:.|..||||.|||...|:..
  Rat   555 FL---VSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVG 616

  Fly   630 ATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVY 694
            ..||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||:..|||......|...|:
  Rat   617 GVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVF 681

  Fly   695 RLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHY 758
            ...:..|.:.:||.:.:...||:.||||::|.|.:|:|:|..|| .:.:.||...||.....|.|
  Rat   682 EKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGY 746

  Fly   759 AIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFE--EPDPDATPDMTFEELRGIF 821
            .||.|.|:..|:.:::|:|||:|:|.|..||.|||.: ...|..  ....|.|..::...:.|:|
  Rat   747 GIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYD-KGECGSGGGDSKDKTSALSLSNVAGVF 810

  Fly   822 YTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRT 886
            |.|..|:.:|.|:.:.||             .:|...:.:.....|:                  
  Rat   811 YILIGGLGLAMLVALIEF-------------CYKSRSESKRMKGFCL------------------ 844

  Fly   887 TPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGR 933
            .|::|:::::             |:|...|....|:....||...||
  Rat   845 IPQQSINEAI-------------RTSTLPRNSGAGASGGGGSGENGR 878

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIICNP_608557.4 PBP1_iGluR_Kainate 26..404 CDD:107377 90/399 (23%)
Periplasmic_Binding_Protein_Type_1 <279..363 CDD:299141 16/87 (18%)
PBP2_iGluR_Kainate 423..794 CDD:270432 142/377 (38%)
Lig_chan 554..828 CDD:278489 101/282 (36%)
Gria1NP_113796.1 PBP1_iGluR_AMPA_GluR1 26..392 CDD:380613 91/401 (23%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 143/386 (37%)
Glutamate binding. /evidence=ECO:0000250 492..494 0/1 (0%)