Protein Alignment GluRIIC and GluRIB

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001261621.2
• Gene: GluRIB / 44484
• FlyBaseID: FBgn0264000
• Length: 1182
• Species: Drosophila melanogaster
• Alignment Length: 1018
• Identity: 241/1018 - (23%)
• Similarity: 421/1018 - (41%)
• Gaps: 228/1018 - (22%)

  Fly     6 LLLGCMWSAF--FMCRSRG----------------QQINIGAFFYDDELELEKEFMTVVNAINGP 52
            |.|.|:|.:|  ::..|.|                ::|.:||.|.....|::..|...:...|..
  Fly     5 LKLSCLWPSFLLWLTWSSGGGGGSGVGVSAQPSLTEKIPLGAIFEQGTDEVQSAFKYAMLNHNLN 69

  Fly    53 ESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEF 117
            .|.:.......:..:...| :..:....|:....||.::.|..|..:.|.:....|:..:|.:..
  Fly    70 VSSRRFELQAYVDVINTAD-AFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTP 133

  Fly   118 DISDEGIQAEKPNHQMTLNLYP--AQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ 180
            ...::.:..........|::.|  .|||:     |.:|.:||||...:||:.|  ...|||.:.|
  Fly   134 WFPEKVLTPSSGFLDFALSMRPDYHQAII-----DTIQFYGWRKIIYLYDSHD--GLLRLQQIYQ 191

  Fly   181 LREVHND------VVRVRKFHKDDDFRVMWKSI-RGE-RRVVLDCEPNMLVELLNSSTEFGLTGQ 237
            .....|:      |.|:.......:|....:.| |.| :.:||||...|..::|
  Fly   192 GLRPGNESFQVELVKRISNVSMAIEFLHTLEQIGRFENKHIVLDCPTEMAKQIL----------- 245

  Fly   238 YNHIFLTNLETYTDH--LEELAADN-------ETFAVNITAARL------LVNPD-------PPP 280
            ..|:....|...|.|  |..|..|:       |..|:|||..|:      ||...       .|.
  Fly   246 IQHVRDLRLGRRTYHYLLSGLVMDDRWESEIIEFGAINITGFRIVDTNRRLVREFYDSWKRLDPQ 310

  Fly   281 YSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDR-----------MVV 334
            .|:..|    |::|..:::         |::||:.:..:::.......||:           ::|
  Fly   311 MSVGAG----RESISAQAA---------LMYDAVFVLVEAFNKILRKKPDQFRNNVQRRSQTLMV 362

  Fly   335 PRITC-------DFAASGG------------------------------------RTWAMG---- 352
            .:...       :::||||                                    ..|..|
  Fly   363 AQAAASTSSDGYNYSASGGGGGNGGAGGGFAGSDSGGSGGMASRALDCNTAKGWVNAWEHGDKIS 427

  Fly   353 RYLARL-MKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDG---IGIAIWDPRGQITQLNV 413
            |||.:: ::|.:|         .::|::||:|:.:.:.|.:....   :.:|.|:....:..||.
  Fly   428 RYLRKVEIEGLTG---------DIKFNDDGRRVNYTLHVVEMTVNSAMVKVAEWNDDAGLQPLNA 483

  Fly   414 -------DVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYV 471
                   .|:.:|...|.|.|.:..||....:.|....|.||..::||..||.|.:|:.:|..|.
  Fly   484 KYVRLRPHVEFEKNRTYIVTTVLEEPYIMLKQVAFGEKLHGNNRFEGYCKDLADLLAKELGINYE 548

  Fly   472 FVPVADQQYGKLDKETKQ--WNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILA 534
            ...|.|..||. :|.:..  |:|::||::..:|.:.|..:|||..|:..:||:.|||.||:||:.
  Fly   549 LRLVKDGNYGS-EKSSAHGGWDGMVGELVRKEADIAIAAMTITAERERVIDFSKPFMSLGISIMI 612

  Fly   535 YKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDW----------ENPHP--- 586
            .|.......:.:::.|...|:|:.::.|...::.:...|:|.|..:|          ::|.|
  Fly   613 KKPVKQTPGVFSFMNPLSQEIWVSVIFSYIGVSIVLFFVSRFSPHEWRLVQQQPQQSQSPDPHAH 677

  Fly   587 ----CNRDP--------------------------------------------EVLENQWRIHNT 603
                .|:.|                                            ..:.|::.:.|:
  Fly   678 HEQLANQQPPGIIGGAPLPAPPGPPTPGAQTAAGAAALQAALSAGSPGSGGSSSAVVNEFSVWNS 742

  Fly   604 GWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSA 668
            .|.::|:.|..|||:.|||...|:..|:|:.|.:|:.:|||||||||||..:|...|.:.:||:.
  Fly   743 FWFSLAAFMQQGCDLSPRSVSGRIAAASWFFFTLILISSYTANLAAFLTVERMVTPINSPEDLAM 807

  Fly   669 QKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMET 733
            |.:|::||:..|||::....|...::...:..||: ....:.....||:.|||.::|.|..|:|:
  Fly   808 QTEVQYGTLLHGSTWDFFRRSQIGLHNKMWEYMNS-RKHVFVPTYDEGIKRVRNSKGKYALLVES 871

  Fly   734 TTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPN 797
            ...|| :..:.||...||.....|.:.||.|.|:..:..:::|:|.|.|.|||..|:.|||.. .
  Fly   872 PKNEYVNAREPCDTMKVGRNLDTKGFGIATPLGSALKDPINLAVLTLKENGELIKLRNKWWYE-K 935

  Fly   798 ASCFEEPDPDAT-PDMTFEELRGIFYTLYAGILIAFLIGITEF 839
            |.|....|.:.: .:::...:.||||.|..|:|::..:.|.|:
  Fly   936 AECSTHKDGETSHSELSLSNVAGIFYILIGGLLVSVFVAILEY 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	91/476 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	125/434 (29%)
		Lig_chan	554..827	CDD:459656	91/335 (27%)
GluRIB	NP_001261621.2	PBP1_iGluR_AMPA	43..480	CDD:380603	91/477 (19%)
		PBP2_iGluR_AMPA	497..938	CDD:270433	127/443 (29%)
		Lig_chan	630..966	CDD:459656	91/337 (27%)