DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIC and KaiR1D

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_650925.1	Gene:	KaiR1D / 42473	FlyBaseID:	FBgn0038837	Length:	853	Species:	Drosophila melanogaster

Alignment Length:	876	Identity:	297/876 - (33%)
Similarity:	459/876 - (52%)	Gaps:	71/876 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLGCMWSAFFMCRSRGQQINIGAFFY--DDELELEKEFMTVVNAING-----PESEQTMRFYPL 63
            |:|.|.     ..:|....|.||..|:  ||..||  .|...|:.||.     |.|:...:
  Fly    16 LILNCR-----KAQSLPDIIKIGGLFHPADDHQEL--AFRQAVDRINADRSILPRSKLVAQ---- 69

  Fly    64 IKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEK 128
            |:|:.|.| |....:..|.|::.||||||||.|...:..|..:|::..|||:| :..|..::.|
  Fly    70 IERISPFD-SFHAGKRVCGLLNIGVAAIFGPQSSHTASHVQSICDNMEIPHLE-NRWDYRLRRE- 131

  Fly   129 PNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRK 193
               ...:||||....|||||.|||:::||:.|||:|:.:|  ...|||:||:...:....:.||:
  Fly   132 ---SCLVNLYPHPNTLSKAYVDIVRHWGWKTFTIIYENND--GIVRLQELLKAHGMTPFPITVRQ 191

  Fly   194 FHKDDDFRVMWKSIR--GERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEEL 256
            .....|:|.:.|.|:  .|..:||||....:.|:|..:.:.|:...|:...:|:|:.:|.:|:|.
  Fly   192 LSDSGDYRPLLKQIKNSAEAHIVLDCSTERIHEVLKQAQQIGMMSDYHSYLVTSLDLHTVNLDEF 256

  Fly   257 AADNETFAVNITAARL----LVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLF 317
            ...    ..|||..||    :|:.....:|:....:.:..|:....|:..      |::||:.||
  Fly   257 RYG----GTNITGFRLINEKIVSDVVRQWSIDEKGLLRSANLTTVRSETA------LMYDAVHLF 311

  Fly   318 AQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQ 382
            |::..:..  ...::.:..|:||    |..||..|..|...||    :......|::::||..|.
  Fly   312 AKALHDLD--TSQQIDIHPISCD----GQSTWQHGFSLINYMK----IVEMKGLTNVIKFDHQGF 366

  Fly   383 RITFNIEVYD--PLDGIGIAIWD---PRG-----QITQLNVDVKAQ-KKMIYRVATRIGPPYFSY 436
            |..|.:::.:  |.....|..|:   |.|     ..:|...:::|. |.....|.|.:..||...
  Fly   367 RTDFMLDIVELTPAGIRKIGTWNSTLPDGINFTRTFSQKQQEIEANLKNKTLVVTTILSNPYCMR 431

  Fly   437 NETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINND 501
            .|:|  :.|:||..::|||||||..|::.:||.|....|.|..||.|:|.|.:|||:|.|::...
  Fly   432 KESA--IPLSGNDQFEGYAVDLIHEISKSLGFNYKIQLVPDGSYGSLNKLTGEWNGMIRELLEQR 494

  Fly   502 AHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVM 566
            |.:.|.|||||..|:.|||||.|||.||||||..|.......|.::|:|...:|||::..:...:
  Fly   495 ADLAIADLTITFEREQAVDFTTPFMNLGVSILYRKPIKQPPNLFSFLSPLSLDVWIYMATAYLGV 559

  Fly   567 TFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEAT 631
            :.|..|:|:.:..:|  |...:...|.:|:|:.:.|..|..:.|:|..|||.||::...||....
  Fly   560 SVLLFILAKFTPYEW--PAYTDAHGEKVESQFTLLNCMWFAIGSLMQQGCDFLPKALSTRMVAGI 622

  Fly   632 WWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRL 696
            ||.|.:|:.:|||||||||||..:|:..|.:.:||:.|.::|:|.:.||||.....||..:.|:.
  Fly   623 WWFFTLIMISSYTANLAAFLTVERMDSPIESAEDLAKQTRIKYGALKGGSTAAFFRDSKISTYQR 687

  Fly   697 AFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIA 761
            .::.|.:..||.:|..|.|||:||.|.:|.|.||||:|::||..|:||:|..||.....|.|.||
  Fly   688 MWSFMESARPSVFTASNGEGVERVAKGKGSYAFLMESTSIEYVTERNCELTQVGGMLDTKSYGIA 752

  Fly   762 VPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNP--NASCFEE--PDPDATPDMTFEELRGIFY 822
            .|..:.||:.::..||||.|.|:|:.||.||||..  ...|..|  ....|..::....:.|:|.
  Fly   753 TPPNSPYRTAINSVILKLQEEGKLHILKTKWWKEKRGGGKCRVETSKSSSAANELGLANVGGVFV 817

  Fly   823 TLYAGILIAFLIGITEFLVYVQQVALEERLT 853
            .|..|:.:|.:|.:.||:...::||:||||:
  Fly   818 VLMGGMGVACVIAVCEFVWKSRKVAVEERLS 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	115/395 (29%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	19/83 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	153/370 (41%)
		Lig_chan	554..828	CDD:278489	103/277 (37%)
KaiR1D	NP_650925.1	PBP1_iGluR_Kainate	31..397	CDD:107377	117/399 (29%)
		ANF_receptor	42..378	CDD:279440	107/369 (29%)
		Periplasmic_Binding_Protein_Type_2	415..785	CDD:304360	153/373 (41%)
		Lig_chan	547..823	CDD:278489	103/277 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020