Protein Alignment GluRIIC and gria1b

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_991293.1
• Gene: gria1b / 403044
• ZFINID: ZDB-GENE-020125-2
• Length: 917
• Species: Danio rerio
• Alignment Length: 1018
• Identity: 273/1018 - (26%)
• Similarity: 423/1018 - (41%)
• Gaps: 188/1018 - (18%)

  Fly     1 MWQRILLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIK 65
            |||..:||.........|.|....||||..|..|..|.: .|...::..|.            :.
Zfish     1 MWQSFVLLLTGLLGLCSCSSFPSNINIGGLFPTDSHEYD-VFRFALSQHND------------VP 52

  Fly    66 RLKPE------DGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGI 124
            :|.|:      ..|..|....|.....||.||.|...:...:::...|   |..|:.|......|
Zfish    53 KLVPQVDMVDTGSSFAMTYAFCSQFSKGVYAIIGLYDRKTMNMLMSFC---GALHVCFVTPSFPI 114

  Fly   125 QAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLL--------QL 181
            ..   |:|..:.|.|.   |..|...:|:::.|.||..:|.:|.....  ||.:|        |:
Zfish   115 DT---NNQFVIQLRPE---LQDALIALVEHYKWNKFVYMYSSDSGLTV--LQKILDTAAEKTWQV 171

  Fly   182 REVHNDVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNL 246
            ..::.|.:....|.|    .:.....:.|.:::||||...|..:||.........:..|..|.||
Zfish   172 TSINFDTLTEAAFLK----AIQDLDNKKEFKIILDCELERLNSILNLIAAQKKNLKNYHYILANL 232

  Fly   247 ETYTDHLEELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSD---PPRTLIHD 308
            .....:|.|....    ..|:|..:|:      .|:.|....|.:|.:.::|.|   |.|.|.:.
Zfish   233 GFLDLNLTEFRKG----GANVTGFQLM------NYTNPTVSRTIQDWLEFDSKDLKSPKRRLKYT 287

  Fly   309 --LIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGR-------TWAMGRYLARLMKGTSG 364
              |.:|.:.:.|.:::|        :...||......:.|.       .|..|..:.|.::
Zfish   288 GALTYDGVTVMATAFQN--------LRKQRIDISRRGNAGECLANPPAPWGQGIDIQRALQ---- 340

  Fly   365 VNNTNFR--TSILQFDEDGQRITFNIEV--YDPLDGIGIAIWDPRGQI-------TQLNVDVKAQ 418
              ...|.  |..:||::.|.|..|.:.|  :.|.....:..|:.|.:.       ..||.....|
Zfish   341 --QVQFEGLTGHVQFNDKGHRTNFTVSVMEFGPSGPKKVGYWNQREKYVSTATYSNMLNETFGLQ 403

  Fly   419 KKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKL 483
            .: .|.|.|.:..||....:...:  |.||..|:||.|:|...||:|||:.|....|.|.:||..
Zfish   404 NR-TYVVTTILEAPYVMLKKNHEQ--LVGNDKYEGYCVELAAEIAKHVGYSYRLELVGDGKYGAR 465

  Fly   484 DKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYL 548
            |.||..|||::||::...|.:.:..||||..|:..:||:.|||.||:||:..|....:..:.::|
Zfish   466 DAETMMWNGMVGELVYGKADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFL 530

  Fly   549 APFGGEVWIWIL---ISVFVMTFLKTIVARISKMDWE-----------------NPHPCNRDPEV 593
            .|...|:|:.|:   |.|.|:.||   |:|.|..:|.                 :|.| |:.|..
Zfish   531 DPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHADDEEETADQQNQNQPPSPEP-NQSPNQ 591

  Fly   594 LENQ--------------WRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYT 644
            .:||              :.|.|:.|.::.:.|..||||.|||...|:....||.|.:||.:|||
Zfish   592 SQNQREEKQEKQPEHTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYT 656

  Fly   645 ANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAY 709
            ||||||||..:|...|.:.:||:.|.::.:||:.||||......|...|:...::.|.:.:|:.:
Zfish   657 ANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDGGSTKEFFRRSKIAVFEKMWSYMKSAEPTVF 721

  Fly   710 TKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLS 773
            .|...|||.||||::|.|.:|:|:|..|| .:.:.||...||.....|.|.:|.|.|:..|:.::
Zfish   722 VKTTDEGVVRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRNPVN 786

  Fly   774 VAILKLSERGELYDLKQKWWKNPNASCFE--EPDPDATPDMTFEELRGIFYTLYAGILIAFLIGI 836
            :|:|||:|:|.|..||.|||.: ...|..  ....|.|..::...:.|:||.|..|:.:|.|:.:
Zfish   787 LAVLKLNEQGLLDKLKNKWWYD-KGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVAL 850

  Fly   837 TEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPK 901
            .||                 .:|..|.                         .|.:.:.:|....
Zfish   851 VEF-----------------CYKSRIE-------------------------SRRMKQIIDAAML 873

  Fly   902 SSRRVVIGRSSEEMREMA------------QGSGSSSGSNNAG 932
            ||....:|...|..|.||            .|..::.|.:..|
Zfish   874 SSTLTRMGSGGENGRVMAHDFPKGAQTLPCMGQAAAMGLSTTG 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	89/419 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	146/405 (36%)
		Lig_chan	554..827	CDD:459656	105/309 (34%)
gria1b	NP_991293.1	PBP1_iGluR_AMPA_GluR1	26..390	CDD:380613	89/415 (21%)
		PBP2_iGluR_AMPA_GluR1	404..812	CDD:270447	147/415 (35%)