Protein Alignment GluRIIC and GluRIA

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_476855.1
• Gene: GluRIA / 38742
• FlyBaseID: FBgn0004619
• Length: 991
• Species: Drosophila melanogaster
• Alignment Length: 953
• Identity: 239/953 - (25%)
• Similarity: 394/953 - (41%)
• Gaps: 180/953 - (18%)

  Fly    12 WSAFFMCRSRGQ------QINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPE 70
            |..|...:.:.|      :|.:||.|.....:::..|...:...|...|.:.......:..:...
  Fly    21 WPEFSSAQQQQQTVSLTEKIPLGAIFEQGTDDVQSAFKYAMLNHNLNVSSRRFELQAYVDVINTA 85

  Fly    71 DGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHI----------------EFDI 119
            | :..:....|:....||.::.|..|..:.|.:....|:..:|.:                :|.|
  Fly    86 D-AFKLSRLICNQFSRGVYSMLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLAPSSGLLDFAI 149

  Fly   120 SDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREV 184
            |      .:|::.        |||:     |.:|.:||:....:||:.|  ...|||.:.|..:.
  Fly   150 S------MRPDYH--------QAII-----DTIQYYGWQSIIYLYDSHD--GLLRLQQIYQELKP 193

  Fly   185 HNDVVRVRK-------------FHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTG 236
            .|:..||:.             .|..:|.....|     :|:||||...|..|::
  Fly   194 GNETFRVQMVKRIANVTMAIEFLHTLEDLGRFSK-----KRIVLDCPAEMAKEII---------- 243

  Fly   237 QYNHIFLTNLETYTDH--LEELAADN-------ETFAVNITAARLLVN--------PDPPPYSLP 284
             ..|:....|...|.|  |..|..||       |..|:|||..|::.:        .|......|
  Fly   244 -VQHVRDIKLGRRTYHYLLSGLVMDNHWPSDVVEFGAINITGFRIVDSNRRAVRDFHDSRKRLEP 307

  Fly   285 YGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRM----------------- 332
            .|. :|..|....:|.|..:....|::||:.:..:::.......||:.
  Fly   308 SGQ-SQSQNAGGPNSLPAISAQAALMYDAVFVLVEAFNRILRKKPDQFRSNHLQRRSHGGSSSSS 371

  Fly   333 ------VVPRITCDFAASGGRTWAMGRYLARLMK-----GTSGVNNTNFRTSILQFDEDGQRITF 386
                  ....:.|:.:......|..|..::|:::     |.||.         ::|||||:||.:
  Fly   372 ATGTNESSALLDCNTSKGWVTPWEQGEKISRVLRKVEIDGLSGE---------IRFDEDGRRINY 427

  Fly   387 NIEVYD--------------------PLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGP 431
            .:.|.:                    ||.....|........:..:.|    :...|.|::.:..
  Fly   428 TLHVVEMSVNSTLQQVAEWRDDAGLLPLHSHNYASSSRSASASTGDYD----RNHTYIVSSLLEE 488

  Fly   432 PYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETK-QWNGIIG 495
            ||.|..:.....:|.||..::||..||.|.:|..:|.:|....|.|..||..::... .|:|::|
  Fly   489 PYLSLKQYTYGESLVGNDRFEGYCKDLADMLAAQLGIKYEIRLVQDGNYGAENQYAPGGWDGMVG 553

  Fly   496 EIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL 560
            |:|..:|.:.|..:|||..|:..:||:.|||.||:||:..|.......:.::|.|...|:||.::
  Fly   554 ELIRKEADIAISAMTITAERERVIDFSKPFMTLGISIMIKKPVKQTPGVFSFLNPLSQEIWISVI 618

  Fly   561 ISVFVMTFLKTIVARISKMDW------------ENP----------HPCNRDPEVLENQWRIHNT 603
            :|...::|:...|.|....:|            :.|          .|....|.|..|::.:.|:
  Fly   619 LSYVGVSFVLYFVTRFPPYEWRIVRRPQADSTAQQPPGIIGGATLSEPQAHVPPVPPNEFTMLNS 683

  Fly   604 GWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSA 668
            .|.::|:.|..||||.|.|...|:..|.||.|.||:.:|||||||||||..:|...|...:||:.
  Fly   684 FWYSLAAFMQQGCDITPPSIAGRIAAAVWWFFTIILISSYTANLAAFLTVERMVAPIKTPEDLTM 748

  Fly   669 QKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMN-NDDPSAYTKDNLEGVDRVRKNRGDYMFLME 732
            |..|.:||:..|||:.....|...::...:..|| |...|.:|.|  ||:.|||:::|.|..|:|
  Fly   749 QTDVNYGTLLYGSTWEFFRRSQIGLHNKMWEYMNANQHHSVHTYD--EGIRRVRQSKGKYALLVE 811

  Fly   733 TTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNP 796
            :...|| :....||...||.....|.:.:|.|.|:..|..|:.|:|.|.|.|||..::.|||.:
  Fly   812 SPKNEYVNARPPCDTMKVGRNIDTKGFGVATPIGSPLRKRLNEAVLTLKENGELLRIRNKWWFD- 875

  Fly   797 NASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEF 839
            ...|..:.:.....:::...:.||:|.|..|:|:|.::.|.||
  Fly   876 KTECNLDQETSTPNELSLSNVAGIYYILIGGLLLAVIVAIMEF 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	90/476 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	132/395 (33%)
		Lig_chan	554..827	CDD:459656	95/296 (32%)
GluRIA	NP_476855.1	PBP1_iGluR_AMPA	41..456	CDD:380603	88/462 (19%)
		PBP2_iGluR_AMPA	477..879	CDD:270433	133/404 (33%)
		Lig_chan	610..906	CDD:459656	95/298 (32%)