DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and gria3b

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_938174.1	Gene:	gria3b / 368416	ZFINID:	ZDB-GENE-030616-53	Length:	883	Species:	Danio rerio

Alignment Length:	853	Identity:	257/853 - (30%)
Similarity:	405/853 - (47%)	Gaps:	77/853 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPL-----IKRLKPEDG-SVTMQEHA-C 81
            |||||..|....::....|...|...|   :.|.|...|.     :..|:..:. |||   || |
Zfish    23 QINIGGLFMRSTVQEHSAFRFAVQLYN---TNQNMTEKPFHLNYNVDNLESSNSFSVT---HAFC 81

  Fly    82 DLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSK 146
            .....||.||||...|.:.:.:...|   |..|..|......|.::.   |..:.:.|.   |..
Zfish    82 SQFSRGVYAIFGFYDKKSMNTLTSFC---GALHTSFVTPSYPIDSDV---QFVIQMRPP---LKG 137

  Fly   147 AYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDD---FRVMWKSI- 207
            |...::.::.|.||..:||.|  |..:.||.:::....:|..|..|......|   ||.:.:.:
Zfish   138 AVLSLLSHYKWDKFVYLYDTD--RGFSILQAIMEAAVANNWQVTARSVGSITDPQEFRRIIEEMD 200

  Fly   208 -RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAAR 271
             |.|:|.::|||.:.:..:|......|...:..|..:.||......|:::...    ..||:..:
Zfish   201 RRQEKRYLIDCEVDRINVILEQVVTLGKNSRGYHYIIANLGFTNISLDKVFLG----GANISGFQ 261

  Fly   272 LLVNPDPPPYSLPYGYVTQR-----DNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDR 331
             ::||:    :|......||     :....|:.:.|......|.:||:.:.|:::|   :....|
Zfish   262 -IINPE----NLVVQQFLQRWDRLDEREFPEAKNTPLKYTSALSYDAILVIAEAFR---YLRRQR 318

  Fly   332 MVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPL 394
            :.|.|  ...|..|:....|:.|..:.|.:|    :......|..:|||..|:|..:.|:||:..
Zfish   319 VDVSRRGSAGDCLANPAVPWSQGIDIERALK----MVQVQGMTGNIQFDSFGRRTNYTIDVYEMK 379

  Fly   395 DGIG---IAIWDPRGQIT-----QLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALY 451
            .| |   |..|:...:..     |...|..:.:.....|.|.:..||..|.:  ..::|.||..|
Zfish   380 TG-GPRKIGYWNEFERFVNIMDQQFTNDSSSVENRTIVVTTIMEAPYVMYKK--NHMHLEGNEKY 441

  Fly   452 QGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARK 516
            :||.|||...||:|||.:|....|.|.:||..|.|||.|||::||::...|.:.:..||||..|:
Zfish   442 EGYCVDLASEIAKHVGIKYRLSIVMDGKYGARDPETKSWNGMVGELVYGRADIAVAPLTITLVRE 506

  Fly   517 TAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVARISK 578
            ..:||:.|||.||:||:..|....:..:.::|.|...|:|:.|:   |.|.|:.||   |:|.|.
Zfish   507 EVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSP 568

  Fly   579 MDWENPHPCN-RDPEV---LENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIII 639
            .:|:...... :||:.   ..|.:.|.|:.|.::.:.|..||||.|||...|:....||.|.:||
Zfish   569 YEWQLDETDEVKDPQTPPDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLII 633

  Fly   640 ANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNND 704
            .:|||||||||||..:|...|.:.:||:.|.::.:||:..|||......|...||...::.|.:.
Zfish   634 ISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 698

  Fly   705 DPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEY 768
            :||.:.|...:||.||||::|.:.||:|:|..|| .:.:.||...||.....|.|.:|.|.|:..
Zfish   699 EPSVFAKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSAL 763

  Fly   769 RSNLSVAILKLSERGELYDLKQKWWKNPNASCFE--EPDPDATPDMTFEELRGIFYTLYAGILIA 831
            |:.:::|:|||:|:|.|..||.|||.: ...|..  ....|.|..::...:.|:||.|..|:.:|
Zfish   764 RNAVNLAVLKLNEQGLLDKLKNKWWYD-KGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLA 827

  Fly   832 FLIGITEF 839
            .::.:.||
Zfish   828 MMVALIEF 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	96/399 (24%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	19/90 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	145/378 (38%)
		Lig_chan	554..828	CDD:278489	102/283 (36%)
gria3b	NP_938174.1	Periplasmic_Binding_Protein_Type_1	25..396	CDD:299141	96/404 (24%)
		ANF_receptor	36..379	CDD:279440	88/375 (23%)
		PBP2_iGluR_AMPA	412..794	CDD:270433	146/387 (38%)
		Lig_chan	544..824	CDD:278489	102/283 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950