DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and clumsy

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster

Alignment Length:	901	Identity:	335/901 - (37%)
Similarity:	525/901 - (58%)	Gaps:	70/901 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGV 88
            |..:|:.|..|:.|.|..|.|.|:..|  ..|:.:...|::.....:| |..|::..|:||..||
  Fly    24 QFMVGSIFTSDKDESEIAFRTAVDRAN--ILERNVELVPIVVYANTDD-SFIMEKMVCNLISQGV 85

  Fly    89 AAIFGPSSKAASDIVALVCNSTGIPHIEFD-ISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIV 152
            .||||||:.::|||:|.:|::..||||.:| |.:|.| .::.:..||||::|...:||:..|:||
  Fly    86 IAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESI-PDREHSTMTLNVHPDNLLLSQGLAEIV 149

  Fly   153 QNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIR--GERRVVL 215
            |:|.||.||:||:.|  :...:|||:||:.|..::...|::....||.|...|.|:  .:..::|
  Fly   150 QSFAWRSFTVVYETD--KELQQLQDILQVGEPISNPTTVKQLGPGDDHRPFLKEIKLSTDNCLIL 212

  Fly   216 DCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPP 280
            .|.|:.|:::|..:.|..:.|:|..:|:..|:|::....||:.    ...|||..||:   ||..
  Fly   213 HCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSG----VEANITTVRLM---DPSD 270

  Fly   281 YSLPYGYVTQRDNIV------------YESSDPPRT---LIHDLIHDALQLFAQSWRNASFFYPD 330
            :.:        .|:|            |...||.|.   :|  |::||:.||::.......|  :
  Fly   271 FHV--------KNVVHDWEEREKREGRYFKVDPNRVKSQMI--LLNDAVWLFSKGLTELGIF--E 323

  Fly   331 RMVVPRITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYD-PL 394
            .:..|.:.|    ...:.|..|:.:...:|..|...:    |..:.|:|:|||..|.:...: ..
  Fly   324 ELTAPDLEC----RRKKPWPFGKRIIEFIKARSEETS----TGRIDFNENGQRSFFTLRFMELNS 380

  Fly   395 DG-IGIAIWDPRGQITQLNVDVKAQKKM-------IYRVATRIGPPYFSYNETARELNLTGNALY 451
            || :.:|.|||...:..||.|.:::|::       .:.|::|:|.|:.:..|......||||:.|
  Fly   381 DGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRY 445

  Fly   452 QGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARK 516
            :||::|||:.||:.:.|::.|....|.:||.|:|.|:.|:||:.::|:.:|.:||||||:|.:|:
  Fly   446 EGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRR 510

  Fly   517 TAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDW 581
            .|||||.|||.||:|||..|.|.....|.::|:||..:|||::..:...::.|...:||::..||
  Fly   511 QAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDW 575

  Fly   582 ENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTAN 646
            |||||| ::||.:||.|.|.||.||::.|:|..||||||::...|:....||.||:::.||||||
  Fly   576 ENPHPC-KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTAN 639

  Fly   647 LAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTK 711
            ||||||:|:...||.:.:||:||.|:|:|.:.||||.....|||.:.|:..:..|.:..||.:||
  Fly   640 LAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTK 704

  Fly   712 DNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAI 776
            .|.|||:||:|.:..|.||||:|||||:.|:.|||..:|.....|.|.||:||.:.||..:|.|:
  Fly   705 TNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAV 769

  Fly   777 LKLSERGELYDLKQKWWK--NPNASCFEEPDPDA--TPDMTFEELRGIFYTLYAGILIAFLIGIT 837
            |||.|.|:|.:||:||||  :...:| |:.|.|.  ||::..|.:.|:|..|..|:|.|.::|.|
  Fly   770 LKLGELGQLAELKRKWWKEMHGGGNC-EKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCT 833

  Fly   838 EFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPI----VAGTPISSVRTTPR 889
            |||..|:.||:||:::.|:|||.|..|...:|...||:    .:|:..||..::.|
  Fly   834 EFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSR 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	119/397 (30%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/98 (18%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	171/370 (46%)
		Lig_chan	554..828	CDD:278489	126/277 (45%)
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	121/402 (30%)
		ANF_receptor	39..379	CDD:279440	111/372 (30%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	171/373 (46%)
		Lig_chan	548..812	CDD:278489	122/265 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449684
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6275
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900