DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GluRIIB

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	921	Identity:	370/921 - (40%)
Similarity:	552/921 - (59%)	Gaps:	73/921 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 INIGAFFYDDELELEKEF---MTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDN 86
            |.|||.|:|.|::|...|   :..||||| |..:     ...|||....|.|:.:|:.:||||.:
  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAIN-PALK-----LDAIKRYVTVDDSIVLQDISCDLIGS 83

  Fly    87 GVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADI 151
            |||||||||||..||||.::||.|||||::||...:....|:.|||:|:|:.|.:..||.|::||
  Fly    84 GVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDI 148

  Fly   152 V--QNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRG--ERR 212
            :  :.|.|:.|||.|:.  :....|||.:|..:::|...:::::|.:.||:|::||.|..  |:.
  Fly   149 LASKTFDWKSFTIAYER--SSHLIRLQHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKF 211

  Fly   213 VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPD 277
            |:|||..::||:::|:|..:.:||.:||:|||||:|:...::...:.:.|.||.....|..|
  Fly   212 VLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYV--- 273

  Fly   278 PPPYSLPYGYVTQRDNI-VYESSDPPR--TLIHDLIHDALQLFAQSWRNAS---FFYPDRMVVPR 336
            |||.         .|.| |:::|...|  :|...|::|::.||..:....|   .||     :|.
  Fly   274 PPPV---------HDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFY-----IPN 324

  Fly   337 ITCDFAASGGRTWAMGRYLARLMKG-TSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIA 400
            .:|     |...|..|..|...||. |..:....|:|..||.:.||||..||:|||:|:......
  Fly   325 FSC-----GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTH 384

  Fly   401 IWDPRGQITQL-----------------NVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGN 448
            ||:...|:...                 |.:..:||.:.|.||||:|.||||:.|....::..||
  Fly   385 IWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGN 449

  Fly   449 ALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQ 513
            ..::|||||||..:|:...|::.|.||.|.:||..|..|.:|:|||.::|:|:|.:|||||||||
  Fly   450 ERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQ 514

  Fly   514 ARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISK 578
            ||::.|||||||||||:|||:||.|..:..:.|:|.|:..|||::::|::.:..|......||.:
  Fly   515 ARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQ 579

  Fly   579 MDWENP-HPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANS 642
            .:|:.| ...||:.| .:|.|.:.|..||.:.|::..|||:|||...:|:..|.|||||::|:.:
  Fly   580 YEWDQPVENVNREME-RQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQT 643

  Fly   643 YTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPS 707
            |.|.||||:||||:.|.|.:|.||..|.||:||||.||:|....::||:|..|:|:|.|.:..|.
  Fly   644 YIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPD 708

  Fly   708 AYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNL 772
            |:||:|.||||||:.::|.|.||||||.|:|:.::||:|..:||.||||||.||||..|::||||
  Fly   709 AFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNL 773

  Fly   773 SVAILKLSERGELYDLKQKWWKNPNASCFEEPDP---DATPDMTFEELRGIFYTLYAGILIAFLI 834
            ||.||:|||||||:.|:.||: |.|.|..:...|   |...||  :.:.|:|..|..|:::..:|
  Fly   774 SVGILRLSERGELFKLRNKWF-NSNESTCDSNVPTIDDGQFDM--DSVGGLFVVLIVGVVVGLVI 835

  Fly   835 GITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDK----S 895
            |:.|||.:||:::::|::....|.|.|..||:..|..|||:..........:|...||::    |
  Fly   836 GVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSAS 900

  Fly   896 LDRTPKSSRRV 906
            ..:..|.:||:
  Fly   901 SAKKKKKTRRI 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	143/391 (37%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	23/90 (26%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	187/371 (50%)
		Lig_chan	554..828	CDD:278489	129/277 (47%)
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	144/396 (36%)
		ANF_receptor	41..378	CDD:279440	133/366 (36%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	187/374 (50%)
		Lig_chan	555..822	CDD:278489	127/270 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449681
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000