DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GluRIIA

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	932	Identity:	401/932 - (43%)
Similarity:	576/932 - (61%)	Gaps:	66/932 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKP 69
            |:::|.:.....:......:|.:||.||::|.|:|..|......:|..:..: :||. .|||..|
  Fly    12 IIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSE-LRFV-TIKRYMP 74

  Fly    70 EDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMT 134
            .:.|..:|:..|:||.|||||||||||||||||||.:.|:|||||||:|:..|..:.|:.||||:
  Fly    75 TNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMS 139

  Fly   135 LNLYPAQAILSKAYADIVQ-NFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKF-HKD 197
            :|:.|:.::||:||.:|:: |:.||.||::|:..:  ..||||||:.::.:::|.|::|.. ...
  Fly   140 INVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPE--GLARLQDLMNIQALNSDYVKLRNLADYA 202

  Fly   198 DDFRVMWKSIR---GERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAAD 259
            ||:|::||...   .|:|::|||||..|.|||..|.:|.|.|.:.:.|||:|:|:...|.::.
  Fly   203 DDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIY-- 265

  Fly   260 NETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNA 324
            ||.|..|||:.||.| .|..|:......:|:.|.|:..     :|::..||:||:.|||.|.||.
  Fly   266 NEDFKANITSVRLKV-VDANPFERKKTRLTKVDQILGN-----QTMLPILIYDAVVLFASSARNV 324

  Fly   325 ----SFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGTSGVN-NTNFRTSILQFDEDGQRI 384
                ..|:|     |...|    .....|.:|.::...||..|..: ..:|:|..::.||.||||
  Fly   325 IAAMQPFHP-----PNRHC----GSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRI 380

  Fly   385 TFNIEVYDPLDGIGIAIWDPRGQITQ--LNVDVK--------AQKKMIYRVATRIGPPYFSYNET 439
            .||:|:|.|.....:.:|.|...|.:  ||::::        ::::.:|.|.|....|||...|.
  Fly   381 HFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKED 445

  Fly   440 ARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHM 504
            ..  |..|...|:|||||||..::..:.|:|.|:.|...  ||.:.|||||:|||.::|::.|.:
  Fly   446 HE--NFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGN--GKYNPETKQWDGIIRKLIDHHAQI 506

  Fly   505 GICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFL 569
            |:|||||||.|::.|||||||||||:|||.||||...|...|:|.||..||||:::.:..:||..
  Fly   507 GVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLA 571

  Fly   570 KTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWI 634
            ...:||:|..:|..|:|..:||:.|||.|.::|:.||.|.|||..|||||||.|.:|:....||.
  Fly   572 FVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWF 636

  Fly   635 FAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFN 699
            ||:::.::|||||||||||:|.:.||.:|:||..|.||.||::.||||....::||:|.|:.|:|
  Fly   637 FALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWN 701

  Fly   700 LMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPF 764
            .|.:.:|||:|..|.|||.||||.:|.|.||||||:|.|:.|:||||..:||:.|||||.:|||.
  Fly   702 QMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPL 766

  Fly   765 GAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASC--FEEPDPDATPDMTFEELRGIFYTLYAG 827
            |::||:||||:||:|||||||..:|.|||||.|.:|  :.|.|.|   :::..||.|:|..|..|
  Fly   767 GSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGD---ELSIIELGGVFLVLAGG 828

  Fly   828 ILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSL 892
            :||..::||.|||..||.||:|||:|...|||.|:.|.|..|..:||:    .|||       |.
  Fly   829 VLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKKPM----RISS-------SS 882

  Fly   893 DKSLDRTPKSSRRVVIGRSSEE 914
            |||..|....||     |||:|
  Fly   883 DKSSSRRSSGSR-----RSSKE 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	150/387 (39%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	23/87 (26%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	192/370 (52%)
		Lig_chan	554..828	CDD:278489	140/275 (51%)
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	151/391 (39%)
		ANF_receptor	46..386	CDD:279440	140/360 (39%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	192/373 (51%)
		Lig_chan	556..828	CDD:278489	140/274 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449679
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16847at50557
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000