Protein Alignment GluRIIC and Nmdar2

DIOPT Version :9

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001014714.1
• Gene: Nmdar2 / 31107
• FlyBaseID: FBgn0053513
• Length: 1083
• Species: Drosophila melanogaster
• Alignment Length: 1053
• Identity: 227/1053 - (21%)
• Similarity: 410/1053 - (38%)
• Gaps: 272/1053 - (25%)

  Fly    23 QQINIGAFFYDDELELEKEFMTVVNAINGPES--------------EQTMRFYPLIKRLKPEDGS 73
            :|:|||...........:...::.||:.|...              ||....:.::. |.|...:
  Fly    99 EQLNIGLIAPHTNFGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMS-LTPSPTA 162

  Fly    74 VTMQEHACDLIDNGVAAI--------FGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPN 130
            : :.....:.:...|:||        ||.|:.:|...:.| ....|||.|.::..:.|::.....
  Fly   163 I-LSTLCKEFLRVNVSAILYMMNNEQFGHSTASAQYFLQL-AGYLGIPVISWNADNSGLERRASQ 225

  Fly   131 HQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDA----DDARAAARLQDLLQLRE-----VHN 186
            ..:.|.|.|:....|.|...|::.:.|.:|::|...    ||...|.| :.:.:::|     :.|
  Fly   226 STLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVR-ERVAEMQEHFKFTILN 289

  Fly   187 DVVRVRKFHKDDDFRVMWKSIRGERRV-VLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYT 250
            .:|..|...       :.:.:..|.|| :|.......:.:|.::.|..|||: |::::.:...
  Fly   290 SIVVTRTSD-------LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGE-NYVWVVSQSV-- 344

  Fly   251 DHLEELAADNETFAVNI------TAARLLVNPDPPPYSL-PYG---YVT---QRDNIVYESSDPP 302
              :|:..|.:: |.|.:      |::..|:|.......: .||   |:|   .||.
  Fly   345 --IEKKDAHSQ-FPVGMLGVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDR--------- 397

  Fly   303 RTLIHDLIHDALQLFAQS----------WRNASFFYPDRMVV--------PRITCDFAASGGRTW 349
                        :|..||          |.|...|:.....|        |.|  :|.|.|....
  Fly   398 ------------RLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNI--EFTADGDLRS 448

  Fly   350 AMGRYLARLMKGTSGVNNTNFRTSILQFDEDG--------------------------------- 381
            |.    .::|......||.|     |.::|.|
  Fly   449 AE----LKIMNLRPSANNKN-----LVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVPEKFH 504

  Fly   382 QRITF-------NIEVYDPLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNET 439
            .:|||       |:...||:.  |..:.| ||.:.::..|                      :|.
  Fly   505 LKITFLEEAPYINLSPADPVS--GKCLMD-RGVLCRVAAD----------------------HEM 544

  Fly   440 ARELNL----TGNALYQ---GYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEI 497
            |.::::    ...:.||   |:.:||::..|..:||.|..|.|.|.::|.|  |..:|||:|.::
  Fly   545 AADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKWGTL--ENGKWNGLIADL 607

  Fly   498 INNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYK-----SPHVEKTLDAYLAPFGGEVWI 557
            :|....|.:..|.|...|:..|||:.|||:.|::|:..|     ||      .|:|.||....|:
  Fly   608 VNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISP------TAFLEPFDTASWM 666

  Fly   558 WI-LISVFVMTFLKTIVARISKMDWENPHPCN-----RDPEVLENQWRIHNTGWLTVASIMTAGC 616
            .: ::::...||:      |...:|.:|...:     ::..|...::.:..|.||..|.:..|..
  Fly   667 LVGIVAIQAATFM------IFLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAV 725

  Fly   617 DI-LPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKD------LSAQKKVKF 674
            .: .||....|.....|.:||::....||||||||:.:.:.....:.|.|      .|.:...||
  Fly   726 HVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKF 790

  Fly   675 GTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNL-EGVDRVRKNRGDYMFLMETTTLEY 738
            |||....|       :.|:::. ||:|:| ....|.|.:: :||..|.....| .|:.:.|.|:|
  Fly   791 GTIPYSHT-------DSTIHKY-FNVMHN-YMRQYNKTSVADGVAAVLNGNLD-SFIYDGTVLDY 845

  Fly   739 --HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK---NPNA 798
              .::::|.|.:||..:....|.:|....::|....:..:|:....|:|..|::.|..   .|..
  Fly   846 LVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGK 910

  Fly   799 SCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITE--FLVYVQQ---------------V 846
            ...:..||     :..|:....|..|.||||:|.|:.:.|  :..|:::               :
  Fly   911 QEHKSSDP-----LALEQFLSAFLLLMAGILLAALLLLLEHVYFKYIRKRLAKKDGGHCCALISL 970

  Fly   847 ALEERLTFKDAF--------KKEIRFVLC---VWNNRKPIVAGTPISSVRTTPRRSLDKSLDRTP 900
            ::.:.|||:.|.        |......:|   :|..:..:    .:|.:|.   |.|:|.:|:..
  Fly   971 SMGKSLTFRGAVFEATEILKKHRCNDPICDTHLWKVKHEL----DMSRLRV---RQLEKVMDKHG 1028

  Fly   901 KSSRRVVIGRSSE 913
            ..:.::.:..||:
  Fly  1029 IKAPQLRLASSSD 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	90/480 (19%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	20/108 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	103/398 (26%)
		Lig_chan	554..828	CDD:278489	69/292 (24%)
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	84/439 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	114/454 (25%)
		Lig_chan	665..928	CDD:278489	66/283 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462665
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940