DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIC and Gria3

DIOPT Version :9

Sequence 1:NP_608557.4 Gene:GluRIIC / 33275 FlyBaseID:FBgn0046113 Length:940 Species:Drosophila melanogaster
Sequence 2:NP_001106213.1 Gene:Gria3 / 29628 RGDID:70958 Length:888 Species:Rattus norvegicus


Alignment Length:867 Identity:259/867 - (29%)
Similarity:410/867 - (47%) Gaps:65/867 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 INIGAFFYDDELELEKEFMTVVNAINGPE--SEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNG 87
            |:||..|..:.::....|...|...|..:  :|:.......:..| ....|.::....|.....|
  Rat    28 ISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHL-DSSNSFSVTNAFCSQFSRG 91

  Fly    88 VAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIV 152
            |.||||...:.:.:.:...|   |..|..|........|:.   |..:.:.||   |..|...::
  Rat    92 VYAIFGFYDQMSMNTLTSFC---GALHTSFVTPSFPTDADV---QFVIQMRPA---LKGAILSLL 147

  Fly   153 QNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFH--KD-DDFRVMWKSI--RGERR 212
            ..:.|.||..:||.:  |..:.||.:::....:|..|..|...  || .:||.:.:.:  |.|:|
  Rat   148 GYYKWEKFVYLYDTE--RGFSVLQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKR 210

  Fly   213 VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPD 277
            .::|||...:..:|......|...:..|..|.|| .:||.|.|.....   ..|||..:::.|.:
  Rat   211 YLIDCEVERINTILEQVVILGKHSRGYHYMLANL-GFTDILLERVMHG---GANITGFQIVNNEN 271

  Fly   278 PPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPR--ITCD 340
            |........:|...:....|:.:.|......|.|||:.:.|:::|   :....|:.|.|  ...|
  Rat   272 PMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFR---YLRRQRVDVSRRGSAGD 333

  Fly   341 FAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYD-PLDGIGIA-IWD 403
            ..|:....|:.|..:.|.:|    :......|..:|||..|:|..:.|:||: .:.|...| .|:
  Rat   334 CLANPAVPWSQGIDIERALK----MVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWN 394

  Fly   404 PRGQIT-----QLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIA 463
            ...:..     |::.|..:.:.....|.|.:..||..|.:...:|.  ||..|:||.|||...||
  Rat   395 EYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLE--GNERYEGYCVDLAYEIA 457

  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528
            :||..:|....|.|.:||..|.|||.|||::||::...|.:.:..||||..|:..:||:.|||.|
  Rat   458 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSL 522

  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDW----ENPHP 586
            |:||:..|....:..:.::|.|...|:|:.|:   |.|.|:.||   |:|.|..:|    .|..|
  Rat   523 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHLEDNNEEP 584

  Fly   587 CNRDPEV---LENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLA 648
              |||:.   ..|::.|.|:.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||
  Rat   585 --RDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 647

  Fly   649 AFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDN 713
            ||||..:|...|.:.:||:.|.::.:||:..|||......|...||...::.|.:.:||.:||..
  Rat   648 AFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTT 712

  Fly   714 LEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAIL 777
            .:||.||||::|.:.||:|:|..|| .:.:.||...||.....|.|.:|.|.|:...:.:::|:|
  Rat   713 ADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVL 777

  Fly   778 KLSERGELYDLKQKWWKNPNASCFE--EPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFL 840
            ||:|:|.|..||.|||.: ...|..  ....|.|..::...:.|:||.|..|:.:|.::.:.||.
  Rat   778 KLNEQGLLDKLKNKWWYD-KGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFC 841

  Fly   841 VYVQQVALEERLT-----FKDA 857
            ...:..:...:||     ||.|
  Rat   842 YKSRAESKRMKLTKNTQNFKPA 863

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIICNP_608557.4 PBP1_iGluR_Kainate 26..404 CDD:107377 92/388 (24%)
Periplasmic_Binding_Protein_Type_1 <279..363 CDD:299141 18/85 (21%)
PBP2_iGluR_Kainate 423..794 CDD:270432 147/381 (39%)
Lig_chan 554..828 CDD:278489 105/286 (37%)
Gria3NP_001106213.1 PBP1_iGluR_AMPA_GluR3 29..400 CDD:107382 92/393 (23%)
ANF_receptor 40..383 CDD:279440 86/365 (24%)
PBP2_iGluR_AMPA 416..799 CDD:270433 148/390 (38%)
Glutamate binding 502..504 0/1 (0%)
Lig_chan 548..829 CDD:278489 105/286 (37%)