Protein Alignment GluRIIC and Gria2

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_058957.1
• Gene: Gria2 / 29627
• RGDID: 61862
• Length: 883
• Species: Rattus norvegicus
• Alignment Length: 891
• Identity: 256/891 - (28%)
• Similarity: 413/891 - (46%)
• Gaps: 120/891 - (13%)

  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFF---YDDELELEKEFMTVVNAINGPESEQTMRFYPLIKR 66
            :||...:|...|...|  ..|.||..|   .|.|....:     |..:....||  .|..|.|..
  Rat     9 VLLSPVLWGLIFGVSS--NSIQIGGLFPRGADQEYSAFR-----VGMVQFSTSE--FRLTPHIDN 64

  Fly    67 LKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH 131
            |:..: |..:....|.....||.||||...|.:.:.:...|.:..:..|......:|      .|
  Rat    65 LEVAN-SFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG------TH 122

  Fly   132 QMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLL-------------QLRE 183
            ...:.:.|.   |..|...:::.:.|.||..:||:|  |..:.||.:|             .:..
  Rat   123 PFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSD--RGLSTLQAVLDSAAEKKWQVTAINVGN 182

  Fly   184 VHNDVVRVRKFHKDDDFRVMWK--SIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNL 246
            ::||       .||:.:|.:::  .::.||||:||||.:.:.::::.....|...:..|..:.||
  Rat   183 INND-------KKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL 240

  Fly   247 ETYTDHLEELAADNETFAVNITAARL----LVNPDPPPYSLPYGYVTQRDNIVYESSDP---PRT 304
             .:|        |.:...:....|.:    :|:.|.   ||...:: :|.:.:.|...|   ..|
  Rat   241 -GFT--------DGDLLKIQFGGANVSGFQIVDYDD---SLVSKFI-ERWSTLEEKEYPGAHTAT 292

  Fly   305 LIHD--LIHDALQLFAQSWRNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMK----- 360
            :.:.  |.:||:|:..:::||   ....|:.:.|  ...|..|:....|..|..:.|.:|
  Rat   293 IKYTSALTYDAVQVMTEAFRN---LRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVE 354

  Fly   361 GTSGVNNTNFRTSILQFDEDGQRITFNIEV-------------YDPLDGIGIAIWD-PRGQITQL 411
            |.||         .::||::|:||.:.|.:             :..:|.:.:.:.: |.|.
  Rat   355 GLSG---------NIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGN---- 406

  Fly   412 NVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVA 476
              |....:.....|.|.:..||....:. .|: |.||..|:||.|||...||:|.||:|....|.
  Rat   407 --DTSGLENKTVVVTTILESPYVMMKKN-HEM-LEGNERYEGYCVDLAAEIAKHCGFKYKLTIVG 467

  Fly   477 DQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVE 541
            |.:||..|.:||.|||::||::...|.:.|..||||..|:..:||:.|||.||:||:..|....:
  Rat   468 DGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532

  Fly   542 KTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDWENPH-PCNRDPEVLE--NQWRI 600
            ..:.::|.|...|:|:.|:   |.|.|:.||   |:|.|..:|.... ...|:.:..|  |::.|
  Rat   533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHTEEFEDGRETQSSESTNEFGI 594

  Fly   601 HNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKD 665
            .|:.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||||||..:|...|.:.:|
  Rat   595 FNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 659

  Fly   666 LSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFL 730
            ||.|.::.:||:..|||......|...|:...:..|.:.:||.:.:...|||.||||::|.|.:|
  Rat   660 LSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL 724

  Fly   731 METTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK 794
            :|:|..|| .:.:.||...||.....|.|.||.|.|:...:.:::|:|||||:|.|..||.|||.
  Rat   725 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWY 789

  Fly   795 NP-NASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEF 839
            :. .....:....:.|..::...:.|:||.|..|:.:|.|:.:.||
  Rat   790 DKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	92/430 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	146/377 (39%)
		Lig_chan	554..827	CDD:459656	101/280 (36%)
Gria2	NP_058957.1	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	90/420 (21%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	147/385 (38%)
		Required for interaction with IQSEC1. /evidence=ECO:0000269|PubMed:20547133	867..877