DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIC and Grik1

DIOPT Version :9

Sequence 1:NP_608557.4 Gene:GluRIIC / 33275 FlyBaseID:FBgn0046113 Length:940 Species:Drosophila melanogaster
Sequence 2:NP_001104587.1 Gene:Grik1 / 29559 RGDID:2732 Length:949 Species:Rattus norvegicus


Alignment Length:928 Identity:274/928 - (29%)
Similarity:458/928 - (49%) Gaps:117/928 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWQRILLLGCMWS-AFFMC----RSRGQQINIGAFFYDDELE----LEKEFMTVVNAINGPES-- 54
            :|.|    ...|: .:|:|    ::..|.:.||..|...|.|    .|..|...|.:||...:  
  Rat    12 LWTR----DTSWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLM 72

  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDI 119
            ..|...|. |:|:...| |......|||.:..||||:||||..::...|..:||:..:|||:...
  Rat    73 PNTTLTYD-IQRINLFD-SFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW 135

  Fly   120 SDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREV 184
            ....:.:   .....:||||..|.:|:|..|:|..:.|:..|:||  :|:....|||:|::....
  Rat   136 KHPSVDS---RDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVY--EDSTGLIRLQELIKAPSR 195

  Fly   185 HNDVVRVRKF-HKDDDFRVMWKSIRGERR--VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNL 246
            :|..:::|:. ..:.|.:.:.|.::..:.  |:.||......|:|......|:..:|.|.|.|.|
  Rat   196 YNIKIKIRQLPPANKDAKPLLKEMKKSKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTL 260

  Fly   247 ETYTDHLEELAADNETF---AVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESS-----DPPR 303
            :.:       |.|.|.:   .||:|..||| |.|.|..|          :|:.:.|     .|||
  Rat   261 DLF-------ALDLELYRYSGVNMTGFRLL-NIDNPHVS----------SIIEKWSMERLQAPPR 307

  Fly   304 ----------TLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARL 358
                      |....|::||:.:.|.:...||     ::.|..:.|    ...:.|.:|.....|
  Rat   308 PETGLLDGMMTTEAALMYDAVYMVAIASHRAS-----QLTVSSLQC----HRHKPWRLGPRFMNL 363

  Fly   359 MK-----GTSG---VNNT-----NFRTSILQFDEDG-QRITFNI--EVYDPLDGIGIAIWDPRGQ 407
            :|     |.:|   .|.|     :|...|:...|:| ::.:..:  .:|.....||  ||:....
  Rat   364 IKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIG--IWNSNSG 426

  Fly   408 ITQLN---------VDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIA 463
            :...:         .|..|.:.:|  |.|.:..||..|.::.:.  |.||..::||.:||:..::
  Rat   427 LNMTDGNRDRSNNITDSLANRTLI--VTTILEEPYVMYRKSDKP--LYGNDRFEGYCLDLLKELS 487

  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528
            ..:||.|....|.|.:|| ...:..:|||::.|:|::.|.:.:..||||..|:..:||:.|||.|
  Rat   488 NILGFLYDVKLVPDGKYG-AQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL 551

  Fly   529 GVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPE 592
            |:||| |:.|: ....:.::|.|...::|:::|::...::.:..::||.:..:|.||||||.|.:
  Rat   552 GISIL-YRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSD 615

  Fly   593 VLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKME 657
            |:||.:.:.|:.|..|.::|..|.:::|::...|:....||.|.:||.:|||||||||||..:||
  Rat   616 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERME 680

  Fly   658 GSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRK 722
            ..|.:..||:.|.|:::|.:..|||......|..:.|...:..|::...||..|::.||:.||..
  Rat   681 SPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLT 745

  Fly   723 NRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYD 787
            .  ||..|||:|::||..::||:|..:|.....|.|.:..|.|:.||..:::|||:|.|.|:|:.
  Rat   746 T--DYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHM 808

  Fly   788 LKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY------VQQV 846
            :|:|||:  ...|.||...:|:. :..|.:.|||..|.||::::..:.|.|||..      |:|.
  Rat   809 MKEKWWR--GNGCPEEDSKEASA-LGVENIGGIFIVLAAGLVLSVFVAIGEFLYKSRKNNDVEQK 870

  Fly   847 ALEERLTFKDAFKKEIRF 864
            ....||.|  .|:.::||
  Rat   871 GKSSRLRF--YFRNKVRF 886

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIICNP_608557.4 PBP1_iGluR_Kainate 26..404 CDD:107377 110/420 (26%)
Periplasmic_Binding_Protein_Type_1 <279..363 CDD:299141 21/103 (20%)
PBP2_iGluR_Kainate 423..794 CDD:270432 131/371 (35%)
Lig_chan 554..828 CDD:278489 98/273 (36%)
Grik1NP_001104587.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:299141 111/430 (26%)
ANF_receptor 53..396 CDD:279440 98/376 (26%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:304360 132/376 (35%)
Glutamate binding 531..533 0/1 (0%)
Lig_chan 577..846 CDD:278489 98/273 (36%)