DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIC and GRIN2D

DIOPT Version :9

Sequence 1:NP_608557.4 Gene:GluRIIC / 33275 FlyBaseID:FBgn0046113 Length:940 Species:Drosophila melanogaster
Sequence 2:NP_000827.2 Gene:GRIN2D / 2906 HGNCID:4588 Length:1336 Species:Homo sapiens


Alignment Length:991 Identity:207/991 - (20%)
Similarity:367/991 - (37%) Gaps:231/991 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 SVTMQEHACDLID----NGVAAIFGPSSK--AASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH 131
            |:.:|  .|||:.    :||  :|...|:  |.:.|:..:...|.:|.:........:...|...
Human    98 SLVLQ--LCDLLSGLRVHGV--VFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKG 158

  Fly   132 QMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHK 196
            ...|.|..:.....:...::::.:.|..|..|    ..||... :..|...||..|...|...|:
Human   159 STFLQLGSSTEQQLQVIFEVLEEYDWTSFVAV----TTRAPGH-RAFLSYIEVLTDGSLVGWEHR 218

  Fly   197 ----------DDDFRVMWKSIRGERRVVL----DCEPNMLVELLNSSTEFGLTGQYNHIFLTNLE 247
                      :.......:|:..:.|::.    :.||     :..::.|.||||.....|:..  
Human   219 GALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEP-----VFRAAEEAGLTGSGYVWFMVG-- 276

  Fly   248 TYTDHLEELAADNETFAVNITAARLLVNPDPPPY-----SLPYGYVT-----QRDNI-------V 295
                  .:||....:.|           |..||.     .||.|...     .||::       |
Human   277 ------PQLAGGGGSGA-----------PGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGV 324

  Fly   296 YESSDPPRTLIHD------LIHD-----------ALQLFAQ--SWRNASFFYPD-------RMVV 334
            ...:...:.|:.|      |.||           :|..:..  :|.|..:.:.:       .:||
Human   325 AVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVV 389

  Fly   335 PRITCDFAASGGRTWAM-------------------GRYLARLMKGTSGVNNTNFRTSILQFDED 380
            ..:|.|      |||.:                   ||:|       ..|::|...| :...:| 
Human   390 ISLTRD------RTWEVVGSWEQQTLRLKYPLWSRYGRFL-------QPVDDTQHLT-VATLEE- 439

  Fly   381 GQRITFNIEVYDPLDGIGIAIWDPRGQI---TQLNVDVKAQKKMIYRVATRIGPPYFSYNETARE 442
              |....:|..||:.|..|     |..:   :|||             .|...||.....|    
Human   440 --RPFVIVEPADPISGTCI-----RDSVPCRSQLN-------------RTHSPPPDAPRPE---- 480

  Fly   443 LNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGIC 507
                 ....:|:.:|::..:|..:||.|....|.:.::||  |....|||:|||:....|.|.|.
Human   481 -----KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGK--KIDGVWNGMIGEVFYQRADMAIG 538

  Fly   508 DLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIW--------ILISVF 564
            .|||.:.|...|||:|||::.|:|::..:| :...:..|:|.|:...||:.        :.::||
Human   539 SLTINEERSEIVDFSVPFVETGISVMVARS-NGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVF 602

  Fly   565 VMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDI-LPRSPQVRMF 628
            :..:|..:....|....:.|.         .:.:.|..:.||..|.:......: .||....::.
Human   603 IFEYLSPVGYNRSLATGKRPG---------GSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIM 658

  Fly   629 EATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQK------KVKFGTIYGGSTYNLLA 687
            ...|..||:|...|||||||||:...:...:::.|.|...|:      .:||||:..|||...:.
Human   659 VLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIR 723

  Fly   688 DSNETV--YRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRS 748
            .:...:  |.:.:|....:          |.:.:::..:.| .|:.:...|.|  .:::.|.|.:
Human   724 SNYPDMHSYMVRYNQPRVE----------EALTQLKAGKLD-AFIYDAAVLNYMARKDEGCKLVT 777

  Fly   749 V--GEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPD 811
            :  |:.|....|.||:..|:.::..:.:|:|:.....|:..|::.|.   :..|..:.....:..
Human   778 IGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL---SGICHNDKIEVMSSK 839

  Fly   812 MTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQ---VALEERLTFKDAFKKEIRFVLCVWNNRK 873
            :..:.:.|:||.|...:.::.|:...|.|||.:.   :....|:.|..||.:.: :..|......
Human   840 LDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGM-YSCCSAEAAP 903

  Fly   874 PIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNA------- 931
            |.....|......:|.....:.   .|..:..|...|:|.:.....:|:|...|:..|       
Human   904 PPAKPPPPPQPLPSPAYPAPRP---APGPAPFVPRERASVDRWRRTKGAGPPGGAGLADGFHRYY 965

  Fly   932 --------GRGEKEAR 939
                    |.|..|||
Human   966 GPIEPQGLGLGLGEAR 981

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIICNP_608557.4 PBP1_iGluR_Kainate 26..404 CDD:107377 77/412 (19%)
Periplasmic_Binding_Protein_Type_1 <279..363 CDD:299141 26/145 (18%)
PBP2_iGluR_Kainate 423..794 CDD:270432 95/391 (24%)
Lig_chan 554..828 CDD:278489 61/294 (21%)
GRIN2DNP_000827.2 PBP1_iGluR_NMDA_NR2 49..413 CDD:380601 64/353 (18%)
PBP2_iGluR_NMDA_Nr2 430..830 CDD:270436 108/456 (24%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:Q00959 539..541 0/1 (0%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:Q00960 631..650 3/18 (17%)