Protein Alignment GluRIIC and GRIN2C

DIOPT Version :9

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_016880033.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1337
• Species: Homo sapiens
• Alignment Length: 1031
• Identity: 224/1031 - (21%)
• Similarity: 378/1031 - (36%)
• Gaps: 272/1031 - (26%)

  Fly    35 ELELEKEFMTV-VNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFG----- 93
            :|.||.:.:|| ||..| |.|..|                     ..|.|:  |.|.:.|
Human   132 DLPLEIQPLTVGVNTTN-PSSLLT---------------------QICGLL--GAAHVHGIVFED 172

  Fly    94 -PSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEK-PNH---QMTLNLYPAQAILSKAYADIVQ 153
             ..::|.:.|:..:.:.|.:|.:........:...| |..   |:.::|.....:|.|    :::
Human   173 NVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFK----VLE 233

  Fly   154 NFGWRKFTIVYD---------------ADDARAAARLQDLLQLR-EVHNDVVRVRKFHKDDDFRV 202
            .:.|..|.::..               ||.:..:.||.|::.|. .......|.::..:..|..|
Human   234 EYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPV 298

  Fly   203 MWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLT-NLETYTDHLEELAADNETFAVN 266
            .          |..|.......|...:.:.||.|. .|::|. ||
Human   299 F----------VAYCSREEAEVLFAEAAQAGLVGP-GHVWLVPNL-------------------- 332

  Fly   267 ITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFA----QSWRN---- 323
                 .|.:.|.||.:.|.|.:    ::|.||.   |..:...:.|.:.:.|    ..||.
Human   333 -----ALGSTDAPPATFPVGLI----SVVTESW---RLSLRQKVRDGVAILALGAHSYWRQHGTL 385

  Fly   324 -----------------ASFFYPDRMVVPRITCDFAASGG----------------RTWAM---- 351
                             ...||...:.|.....||:.|.|                |.|.|
Human   386 PAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRW 450

  Fly   352 ------------GRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDP 404
                        .||.|.|.   ..|::.:...:.|:     :|....:|..||  |.|..:  |
Human   451 EHGVLYMKYPVWPRYSASLQ---PVVDSRHLTVATLE-----ERPFVIVESPDP--GTGGCV--P 503

  Fly   405 RGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFE 469
            .      .|..:.|....           ||..:.|....|    ..:|:.:|::..:||.|.|.
Human   504 N------TVPCRRQSNHT-----------FSSGDVAPYTKL----CCKGFCIDILKKLARVVKFS 547

  Fly   470 YVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILA 534
            |....|.:.::||  :....|||:|||:....|.|.|..|||.:.|...|||:|||::.|:|::.
Human   548 YDLYLVTNGKHGK--RVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMV 610

  Fly   535 YKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQ-- 597
            .:| :...:..|:|.|:...||    :.:|||..  |:|| |:...:|...|.:.:..:...:
Human   611 ARS-NGTVSPSAFLEPYSPAVW----VMMFVMCL--TVVA-ITVFMFEYFSPVSYNQNLTRGKKS 667

  Fly   598 ----WRIHNTGWLTVASIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKME 657
                :.|..:.||..|.:......| .||....::....|..||:|...|||||||||:...:..
Human   668 GGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYI 732

  Fly   658 GSIANLKDLSAQKK-------------------------------VKFGTIYGGST-YNLLADSN 690
            .:::.|.|    ||                               .:|||:..||| .|:.::..
Human   733 DTVSGLSD----KKSLHLENTGVAWTAFKTFCSDYFQRPQDQYPPFRFGTVPNGSTERNIRSNYR 793

  Fly   691 ET-VYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSV--G 750
            :. .:.:.||..:.:|.....|...|.....||...   |:.:...|.|  .:::.|.|.::  |
Human   794 DMHTHMVKFNQRSVEDALTSLKMGSEAQPVPRKLDA---FIYDAAVLNYMAGKDEGCKLVTIGSG 855

  Fly   751 EKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFE 815
            :.|....|.||:...:.::..:.:|:|:....||...|:..|.   :..|..|.:...:..:..:
Human   856 KVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWL---SGICQNEKNEVMSSKLDID 917

  Fly   816 ELRGIFYTLYAGILIAFLIGITEFLVYVQ---QVALEERLTFKDAFKKEIRFVLCVWNNRKPIVA 877
            .:.|:||.|...:.:|.|:...|.|||.:   .|....:|.|..||.:.|  ..|.
Human   918 NMAGVFYMLLVAMGLALLVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGI--YSCF--------- 971

  Fly   878 GTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGR 933
             :.:.|:.:.||::   |.|.|..|::..|: :..:..|:|...:|.||..:.|.|
Human   972 -SGVQSLASPPRQA---SPDLTASSAQASVL-KMLQAARDMVTTAGVSSSLDRATR 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	83/453 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	26/140 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	104/414 (25%)
		Lig_chan	554..828	CDD:278489	71/317 (22%)
GRIN2C	XP_016880033.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155833
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840