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Protein Alignment GluRIIC and GRIN2B

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	952	Identity:	205/952 - (21%)
Similarity:	348/952 - (36%)	Gaps:	253/952 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 CDLIDN----GVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQ 141
            |||:.:    ||........:|.:.|:..:...|..|.:........|.|:|....|.....|:.
Human    86 CDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSI 150

  Fly   142 AILSKAYADIVQNFGWRKFTIV------YD---------ADDARAAARLQDLLQLREVHNDVVRV 191
            ...:....:|::.:.|..|:||      |.         .:::.....|:::|.|....:|
Human   151 EQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDD---- 211

  Fly   192 RKFHKDDDFRVMWKSIRGERRVVLDC---EPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHL 253
                .|...:...|.::.. .::|.|   |...:.|:.||   .|||| |.:.::..
Human   212 ----GDSKIQNQLKKLQSP-IILLYCTKEEATYIFEVANS---VGLTG-YGYTWIVP-------- 259

  Fly   254 EELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFA 318
            ..:|.|.:|.........:.|:.|...|.||   ...||.|...:     |...|::.:
Human   260 SLVAGDTDTVPAEFPTGLISVSYDEWDYGLP---ARVRDGIAIIT-----TAASDMLSE------ 310

  Fly   319 QSWRNASFFYPDRMVVPRITCDFAASGGRTW---AMGRYLARLMKGTSGVNNTNFRTSILQFDED 380
                  ..|.|:    |:.:| :.....|.:   .:.|||.          |..|....|.|.||
Human   311 ------HSFIPE----PKSSC-YNTHEKRIYQSNMLNRYLI----------NVTFEGRNLSFSED 354

  Fly   381 GQR-------ITFN--------------------------------------------------I 388
            |.:       |..|                                                  :
Human   355 GYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIV 419

  Fly   389 EVYDPLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQG 453
            |..|||.|            |.:...|..||:::....|...|.|.             ....:|
Human   420 ESVDPLSG------------TCMRNTVPCQKRIVTENKTDEEPGYI-------------KKCCKG 459

  Fly   454 YAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTA 518
            :.:|::..|::.|.|.|....|.:.::||  |....|||:|||::...|:|.:..|||.:.|...
Human   460 FCIDILKKISKSVKFTYDLYLVTNGKHGK--KINGTWNGMIGEVVMKRAYMAVGSLTINEERSEV 522

  Fly   519 VDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWEN 583
            |||:|||::.|:|::..:| :...:..|:|.||..:||    :.:|||..:.:.|| :...::.:
Human   523 VDFSVPFIETGISVMVSRS-NGTVSPSAFLEPFSADVW----VMMFVMLLIVSAVA-VFVFEYFS 581

  Fly   584 PHPCNR----DPEVLENQWRIHNTGWLTVASIMTAGCDIL-PRSPQVRMFEATWWIFAIIIANSY 643
            |...||    ..|.....:.|....||....:......:. |:....::..:.|..||:|...||
Human   582 PVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASY 646

  Fly   644 TANLAAFLTSSKMEGSIANLKDLSAQK------KVKFGTIYGGSTYNLLADSNETVYRLAFNLMN 702
            |||||||:...:....::.|.|...|:      ..:|||:..|||..              |:.|
Human   647 TANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTER--------------NIRN 697

  Fly   703 N-DDPSAYT-KDNLEGVD----RVRKNRGDYMFLMETTTLEY--HREQNCDLRSV--GEKFGEKH 757
            | .:..||. |.|..|||    .::..:.| .|:.:...|.|  .|::.|.|.::  |:.|....
Human   698 NYAEMHAYMGKFNQRGVDDALLSLKTGKLD-AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTG 761

  Fly   758 YAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFY 822
            |.||:...:.::..:.:|||:|...||:.:|:..|.   ...|..|.:...:..:..:.:.|:||
Human   762 YGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL---TGICHNEKNEVMSSQLDIDNMAGVFY 823

  Fly   823 TLYAGILIAFLIGITEFLVY----------------------------VQQVALEER-------- 851
            .|.|.:.::.:..|.|.|.|                            :..||:|||
Human   824 MLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPT 888

  Fly   852 LTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLD 893
            .|..:.....:|.:....|...       :|.|..:|:.:||
Human   889 ATMNNTHSNILRLLRTAKNMAN-------LSGVNGSPQSALD 923

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.