Protein Alignment GluRIIC and GRIN2A

DIOPT Version :9

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 1046
• Identity: 218/1046 - (20%)
• Similarity: 399/1046 - (38%)
• Gaps: 257/1046 - (24%)

  Fly    25 INIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYP--------LIKRLKPEDGSVTMQEHAC 81
            :||...........|:|..|    :.|||....:   |        |:.|..|:    ::..|.|
Human    86 LNIAVMLGHSHDVTERELRT----LWGPEQAAGL---PLDVNVVALLMNRTDPK----SLITHVC 139

  Fly    82 DLID----NGVAAIFGPSS--KAASDIVALVCNSTGIPHIEFDISDEGIQAEK-PN---HQMTLN 136
            ||:.    :|:  :||..:  :|.:.::..:.:.|.:|.:........|.|:| |.   .|...:
Human   140 DLMSGARIHGL--VFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGAS 202

  Fly   137 LYPAQAILSKAYADIVQNFGWRKFTIV---------------YDADDARAAARLQDLLQLREVHN 186
            :.....::.|    |:|::.|..|::|               ...|::.....:|:::.|.....
Human   203 IQQQATVMLK----IMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFE 263

  Fly   187 DV---VRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLET 248
            |.   |:::|.|         .|:     ::|.|..:..|.:|:.:...|||| |:..::
Human   264 DAKTQVQLKKIH---------SSV-----ILLYCSKDEAVLILSEARSLGLTG-YDFFWI----- 308

  Fly   249 YTDHLEELAADN-ETFAVNITAARLLVNPDPPPYSL--------------------PYGYVTQRD 292
                :..|.:.| |.......:..:.|:.|...|||                    .:.|:.:..
Human   309 ----VPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAK 369

  Fly   293 NIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTW-AMGRYLA 356
            ...|...:.|...:|.| |..:.......::.||......|.||:.. ...:..|.| .:|::..
Human   370 ASCYGQMERPEVPMHTL-HPFMVNVTWDGKDLSFTEEGYQVHPRLVV-IVLNKDREWEKVGKWEN 432

  Fly   357 RLM----------KGTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDPRGQITQL 411
            ..:          |..|.....:...||:..:|....|   :|..|||....:....|..:..::
Human   433 HTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVI---VEDIDPLTETCVRNTVPCRKFVKI 494

  Fly   412 NVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVA 476
            |                        |.|...:|:  ....:|:.:|::..::|.|.|.|....|.
Human   495 N------------------------NSTNEGMNV--KKCCKGFCIDILKKLSRTVKFTYDLYLVT 533

  Fly   477 DQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVE 541
            :.::||  |....|||:|||::...|.|.:..|||.:.|...|||:|||::.|:|::..:| :..
Human   534 NGKHGK--KVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS-NGT 595

  Fly   542 KTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRD---------PEVLENQ 597
            .:..|:|.||...||:.:.:.:.:::.:...|     .::.:|...||:         |     .
Human   596 VSPSAFLEPFSASVWVMMFVMLLIVSAIAVFV-----FEYFSPVGYNRNLAKGKAPHGP-----S 650

  Fly   598 WRIHNTGWLTVASIMTAGCDIL-PRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIA 661
            :.|....||....:......:. |:....::..:.|..||:|...|||||||||:...:....:.
Human   651 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVT 715

  Fly   662 NLKDLSAQK------KVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAY---TKDNLEGV 717
            .|.|...|:      ..:|||:..|||..              |:.|| .|..:   ||.|.:||
Human   716 GLSDKKFQRPHDYSPPFRFGTVPNGSTER--------------NIRNN-YPYMHQYMTKFNQKGV 765

  Fly   718 D----RVRKNRGDYMFLMETTTLEYH--REQNCDLRSVGEK--FGEKHYAIAVPFGAEYRSNLSV 774
            :    .::..:.| .|:.:...|.|.  |::.|.|.::|..  |....|.||:..|:.::..:.:
Human   766 EDALVSLKTGKLD-AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDL 829

  Fly   775 AILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEF 839
            |:|:....||:.:|:..|.   ...|..|.:...:..:..:.:.|:||.|.|.:.::.:..|.|.
Human   830 ALLQFVGDGEMEELETLWL---TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEH 891

  Fly   840 LVY----------------------------VQQVALEERLTFKDAFKKEIRF--------VLCV 868
            |.|                            :..|.:||:       ||...|        :|.:
Human   892 LFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEK-------KKSPDFNLTGSQSNMLKL 949

  Fly   869 WNNRKPIVAGTPISSVR-TTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAG 932
            ..:.|.|.:.:.::|.| .:|:|:.|             .|.|.|..| :|....|:...|:|..
Human   950 LRSAKNISSMSNMNSSRMDSPKRAAD-------------FIQRGSLIM-DMVSDKGNLMYSDNRS 1000

  Fly   933 RGEKEA 938
            ...||:
Human  1001 FQGKES 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	82/445 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/114 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	99/397 (25%)
		Lig_chan	554..828	CDD:278489	68/300 (23%)
GRIN2A	XP_016878661.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840