DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GRIK4

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001269399.1	Gene:	GRIK4 / 2900	HGNCID:	4582	Length:	956	Species:	Homo sapiens

Alignment Length:	967	Identity:	259/967 - (26%)
Similarity:	431/967 - (44%)	Gaps:	110/967 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEK-EFMTVV---NAIN-GPE----SEQTMRFY 61
            |:|...|.....|.....:|   |...||.:|..: |.:::.   |.|| .||    ::..:..:
Human     8 LVLLPAWLVMVACSPHSLRI---AAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIF 69

  Fly    62 PLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSK-AASDIVALVCNSTGIPHIEFDISDEGIQ 125
            .|::     |......|..|.::..||.|:.||||. |:|.|::.:|....:||  |.::.|...
Human    70 ELLR-----DSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFV 127

  Fly   126 AEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVR 190
            ..:.....||||:|:...:|.|.|.|:..|......::  ...|.....|:.||:...:..|.:.
Human   128 KFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLI--CAKAECLLNLEKLLRQFLISKDTLS 190

  Fly   191 VRKFHKDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHL 253
            ||......|...:.|.||.::  .:::....:|...:|..:.|.|:...|.....||||.....:
Human   191 VRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRM 255

  Fly   254 EELAADNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIVYESSDPPRTLIHDLIHDA 313
            :.|..|.    |||....:. |.....:     ||...:....|::.:........|:.|.::..
Human   256 DSLVDDR----VNILGFSIF-NQSHAFFQEFAQSLNQSWQENCDHVPFTGPALSSALLFDAVYAV 315

  Fly   314 LQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMG----RYLARL-MKGTSG-------VN 366
            :....:..|:      ..:.|..::|..|    :.|..|    .||..: ::|.:|       ..
Human   316 VTAVQELNRS------QEIGVKPLSCGSA----QIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQ 370

  Fly   367 NTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDPRGQITQLNV-DVKAQKKMIYRVATRIG 430
            .:|:...||||..:|.|   .|..:...:|:.:     ...:...|: |......::  |.|.:.
Human   371 RSNYALKILQFTRNGFR---QIGQWHVAEGLSM-----DSHLYASNISDTLFNTTLV--VTTILE 425

  Fly   431 PPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIG 495
            .||.......:|:.  ||..|:|:.||::..:|..:.|.|....|.|..|| :.:....|.|::|
Human   426 NPYLMLKGNHQEME--GNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYG-VPEANGTWTGMVG 487

  Fly   496 EIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT--LDAYLAPFGGEVWIW 558
            |:|...|.:.:..||||..|:..:||:.|||.||:||| |: .|:.:.  ..::|.||...||::
Human   488 ELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISIL-YR-VHMGRKPGYFSFLDPFSPGVWLF 550

  Fly   559 ILISVFVMTFLKTIVARISKMDWENPHPCNRDP-EVLENQWRIHNTGWLTVASIMTAGCDILPRS 622
            :|::...::.:..:|||::..:|.:||||.:.. .:|.||:.:.|:.|..|...|..|..|.||:
Human   551 MLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRA 615

  Fly   623 PQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLA 687
            ...|.....||.|.:||.:|||||||||||..:|:..|.::.||:.|..:::|||:|||:.....
Human   616 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYGTIHGGSSMTFFQ 680

  Fly   688 DSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEK 752
            :|....|:..:|.|.:..||.:.|...||:.||..:  :|.||:|:|..||:|::||:|..:|..
Human   681 NSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQRNCNLTQIGGL 743

  Fly   753 FGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEEL 817
            ...|.|.|.:|.|:.:|....:|||:|.|...|..||:|||:  ...|.:|.|..| ..:..|.:
Human   744 LDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE--GGKCPKEEDHRA-KGLGMENI 805

  Fly   818 RGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPIS 882
            .|||..|..|:::|..:.:.|||                            |..|........:.
Human   806 GGIFVVLICGLIVAIFMAMLEFL----------------------------WTLRHSEATEVSVC 842

  Fly   883 SVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNN--AGRGEKE 937
            ....|..||:....|......||..:......:.|..:..|:::.||.  .|.||.:
Human   843 QEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATLSNGKLCGAGEPD 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	89/406 (22%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	14/93 (15%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	133/373 (36%)
		Lig_chan	554..828	CDD:278489	99/274 (36%)
GRIK4	NP_001269399.1	PBP1_iGluR_Kainate_KA1_2	26..400	CDD:107389	90/403 (22%)
		ANF_receptor	43..382	CDD:279440	79/362 (22%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	133/378 (35%)
		Lig_chan	547..816	CDD:278489	99/273 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..889		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960