DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GRIK3

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	926	Identity:	292/926 - (31%)
Similarity:	466/926 - (50%)	Gaps:	121/926 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WQRILLL------GCMWSAFFMCRSRGQQ--INIGAFF-YDDELEL------EKEFMTVVNAING 51
            |:|:..|      |.:..||::..|||..  |.||..| |.|....      |..|....|.||.
Human     5 WRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINR 69

  Fly    52 PES--EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPH 114
            ..:  ..|...|. |:|:...| |....:.|||.:..||.||||||..:.::.|..:||:..:||
Human    70 NRTLLPNTTLTYD-IQRIHFHD-SFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPH 132

  Fly   115 IEFDISDEGIQAEKPNHQMT------LNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAA 173
                     ||....:|.:.      :||||..|.||.|..|:||...||..|:||  ||:....
Human   133 ---------IQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVY--DDSTGLI 186

  Fly   174 RLQDLLQLREVHNDVVRVRKFHKD-DDFRVMWKSI-RG-ERRVVLDCEPNMLVELLNSSTEFGLT 235
            |||:|:.....:|..:::|:...| ||.|.:.|.: || |.|::.||...|..::|..:...|:.
Human   187 RLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMM 251

  Fly   236 GQYNHIFLTNLETYTDHLEELAADNETF---AVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYE 297
            .:|.|...|.|:.|       |.|.|.:   .||:|..|:| |.|.|..|.          ||.:
Human   252 TEYYHFIFTTLDLY-------ALDLEPYRYSGVNLTGFRIL-NVDNPHVSA----------IVEK 298

  Fly   298 SS-----DPPRT--------LIHD--LIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGR 347
            .|     ..||:        ::.|  |::||:.:.:..::.|     .:|.|..:.|    ...:
Human   299 WSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRA-----PQMTVNSLQC----HRHK 354

  Fly   348 TWAMGRYLARLMK--------------GTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIG 398
            .|..|......:|              .|||: .|:|...|:...|||..   .:.|:.|.||:.
Human   355 AWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGL-RTDFDLDIISLKEDGLE---KVGVWSPADGLN 415

  Fly   399 IA-IWDPRGQITQLNV-DVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDA 461
            |. :...||.    || |....:.:|  |.|.:..|:..:.::.|  .|.||..::||.:||:..
Human   416 ITEVAKGRGP----NVTDSLTNRSLI--VTTVLEEPFVMFRKSDR--TLYGNDRFEGYCIDLLKE 472

  Fly   462 IARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFM 526
            :|..:||.|....|.|.:||..| :..||||::.|:|::.|.:.:..||||..|:.|:||:.|||
Human   473 LAHILGFSYEIRLVEDGKYGAQD-DKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFM 536

  Fly   527 QLGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRD 590
            .|||||| |:.|: ...::.::|.|...::|:::|::...::.:..::||.|..:|.:.||||..
Human   537 TLGVSIL-YRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG 600

  Fly   591 PEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSK 655
            .||:||.:.:.|:.|..:.|:|..|.:::|::...|:....||.|.:||.:|||||||||||..:
Human   601 SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVER 665

  Fly   656 MEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRV 720
            ||..|.:..||:.|.|:::|.:..|:|......|..:.:...:..|:: .|||..|:|.||:.|.
Human   666 MESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSS-KPSALVKNNEEGIQRA 729

  Fly   721 RKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGEL 785
            .  ..||..|||:||:||..::||:|..:|.....|.|.|..|.|:.||..:::|||:|.|..:|
Human   730 L--TADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKL 792

  Fly   786 YDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEE 850
            :.:|:|||:  .:.|.||.:.:|:. :..:::.|||..|.||::::.|:.:.||:..:::.|..|
Human   793 HIMKEKWWR--GSGCPEEENKEASA-LGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAERE 854

  Fly   851 RLTFKDAFKKEIRFVL 866
            :.:|......||||.|
Human   855 QRSFCSTVADEIRFSL 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	120/428 (28%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/112 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	134/371 (36%)
		Lig_chan	554..828	CDD:278489	96/273 (35%)
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	120/426 (28%)
		ANF_receptor	55..398	CDD:279440	107/383 (28%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	135/376 (36%)
		Lig_chan	564..832	CDD:278489	96/273 (35%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860