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Protein Alignment GluRIIC and GRIK2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_068775.1	Gene:	GRIK2 / 2898	HGNCID:	4580	Length:	908	Species:	Homo sapiens

Alignment Length:	946	Identity:	277/946 - (29%)
Similarity:	456/946 - (48%)	Gaps:	149/946 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLGCMWSAFFMCRSRG--QQINIGAFF-YDDELEL---EKEFMTVVNAINGPES---------- 54
            |||..:|..:    |:|  ..:..|..| |.:...:   |..|...||.||...:
Human    19 LLLCLLWIGY----SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYD 79

  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIE--- 116
            .|.:..|          .|....:.|||.:..|||||||||..::::.|..:||:.|:|||:
Human    80 TQKINLY----------DSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW 134

  Fly   117 -FDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ 180
             ..:||.       .....::|||..:.||:|..|:||.|.|:..|:||  ||:....|||:|::
Human   135 KHQVSDN-------KDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVY--DDSTGLIRLQELIK 190

  Fly   181 LREVHNDVVRVRKFHKD-DDFRVMWKSI-RG-ERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIF 242
            ....:|..:::|:...| .|.:.:.|.: || |..|:.||...|...:|..:...|:..:|.|..
Human   191 APSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYI 255

  Fly   243 LTNLETYTDHLEELAADNETF---AVNITAARLLVN-------------------PDPPPYSLPY 285
            .|.|:.:       |.|.|.:   .||:|..|:|..                   |..|...|..
Human   256 FTTLDLF-------ALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313

  Fly   286 GYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWA 350
            |::|....::|::       :| ::..|:|.|.|            |.|..:.|    :..:.|.
Human   314 GFMTTDAALMYDA-------VH-VVSVAVQQFPQ------------MTVSSLQC----NRHKPWR 354

  Fly   351 MGRYLARLMK-----GTSG---VNNTNFRTSILQFDEDGQRITFNIEVY----DPLDGIGIAIWD 403
            .|.....|:|     |.:|   .|.||           |.|..|:::|.    :.|:.||  .||
Human   355 FGTRFMSLIKEAHWEGLTGRITFNKTN-----------GLRTDFDLDVISLKEEGLEKIG--TWD 406

  Fly   404 PRGQITQLN---------VDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLI 459
            |...:....         .|..:.:.:|  |.|.:..||..:.::.:.  |.||..::||.:||:
Human   407 PASGLNMTESQKGKPANITDSLSNRSLI--VTTILEEPYVLFKKSDKP--LYGNDRFEGYCIDLL 467

  Fly   460 DAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVP 524
            ..::..:||.|....|.|.:||..|....||||::.|:|::.|.:.:..|.||..|:..:||:.|
Human   468 RELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532

  Fly   525 FMQLGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCN 588
            ||.||:||| |:.|: ....:.::|.|...::|::||::...::.:..::||.|..:|.||||||
Human   533 FMTLGISIL-YRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCN 596

  Fly   589 RDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTS 653
            .|.:|:||.:.:.|:.|..|.::|..|.:::|::...|:....||.|.:||.:|||||||||||.
Human   597 PDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTV 661

  Fly   654 SKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVD 718
            .:||..|.:..||:.|.|:::|.:..|:|......|..:.|...:..|::...|...|.|.||:.
Human   662 ERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQ 726

  Fly   719 RVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERG 783
            ||..:  ||.||||:||:|:..::||:|..:|.....|.|.:..|.|:.||..:::|||:|.|.|
Human   727 RVLTS--DYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEG 789

  Fly   784 ELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVAL 848
            :|:.:|:|||:  ...|.||...:|:. :..:.:.|||..|.||::::..:.:.|||...::.|.
Human   790 KLHMMKEKWWR--GNGCPEEESKEASA-LGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQ 851

  Fly   849 EERLTFKDAFKKEIRFVLCVWNNRK-----PIVAGT 879
            .|:.:|..|..:|:|..|......|     |::..|
Human   852 LEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKT 887

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.