DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIIC and GRIK1

DIOPT Version :9

Sequence 1:NP_608557.4 Gene:GluRIIC / 33275 FlyBaseID:FBgn0046113 Length:940 Species:Drosophila melanogaster
Sequence 2:NP_001317923.1 Gene:GRIK1 / 2897 HGNCID:4579 Length:949 Species:Homo sapiens


Alignment Length:930 Identity:275/930 - (29%)
Similarity:461/930 - (49%) Gaps:121/930 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWQRILLLGCMWS-AFFMC----RSRGQQINIGAFFYDDELE----LEKEFMTVVNAINGPES-- 54
            :|.|    ...|: .:|:|    ::..|.:.||..|...|.|    .|..|...|.:||...:  
Human    12 LWTR----DTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLM 72

  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDI 119
            ..|...|. |:|:...| |......|||.:..||||:||||..::...|..:||:..:|||:...
Human    73 PNTTLTYD-IQRINLFD-SFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRW 135

  Fly   120 SDEGIQAEKPNHQM-TLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLRE 183
            ....:.    |..: .:||||..|.:|:|..|:|..:.|:..|:||  :|:....|||:|::...
Human   136 KHPSVD----NKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVY--EDSTGLIRLQELIKAPS 194

  Fly   184 VHNDVVRVRKFHK-DDDFRVMWKSIR--GERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTN 245
            .:|..:::|:... :.|.:.:.|.::  .|..|:.||......|:|......|:..:|.|.|.|.
Human   195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTT 259

  Fly   246 LETYTDHLEELAADNETF---AVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESS-----DPP 302
            |:.:       |.|.|.:   .||:|..||| |.|.|..|          :|:.:.|     .||
Human   260 LDLF-------ALDLELYRYSGVNMTGFRLL-NIDNPHVS----------SIIEKWSMERLQAPP 306

  Fly   303 R----------TLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRYLAR 357
            |          |....|::||:.:.|.:...||     ::.|..:.|    ...:.|.:|.....
Human   307 RPETGLLDGMMTTEAALMYDAVYMVAIASHRAS-----QLTVSSLQC----HRHKPWRLGPRFMN 362

  Fly   358 LMK-----GTSG---VNNTN-----FRTSILQFDEDG-QRITFNI--EVYDPLDGIGIAIWDPRG 406
            |:|     |.:|   .|.||     |...|:...|:| ::....:  .:|.....||  ||:...
Human   363 LIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIG--IWNSNS 425

  Fly   407 --QITQLN-------VDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAI 462
              .:|..|       .|..|.:.:|  |.|.:..||..|.::.:.  |.||..::||.:||:..:
Human   426 GLNMTDSNKDKSSNITDSLANRTLI--VTTILEEPYVMYRKSDKP--LYGNDRFEGYCLDLLKEL 486

  Fly   463 ARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQ 527
            :..:||.|....|.|.:|| ...:..:|||::.|:|::.|.:.:..||||..|:..:||:.|||.
Human   487 SNILGFIYDVKLVPDGKYG-AQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMT 550

  Fly   528 LGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDP 591
            ||:||| |:.|: ....:.::|.|...::|:::|::...::.:..::||.:..:|.||||||.|.
Human   551 LGISIL-YRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDS 614

  Fly   592 EVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKM 656
            :|:||.:.:.|:.|..|.::|..|.:::|::...|:....||.|.:||.:|||||||||||..:|
Human   615 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERM 679

  Fly   657 EGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVR 721
            |..|.:..||:.|.|:::|.:..|||......|..:.|...:..|::...:|..:::.||:.||.
Human   680 ESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVL 744

  Fly   722 KNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELY 786
            ..  ||..|||:|::||..::||:|..:|.....|.|.:..|.|:.||..:::|||:|.|.|:|:
Human   745 TT--DYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLH 807

  Fly   787 DLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY-------VQ 844
            .:|:|||:  ...|.||.:.:|:. :..|.:.|||..|.||::::..:.|.|| :|       ::
Human   808 MMKEKWWR--GNGCPEEDNKEASA-LGVENIGGIFIVLAAGLVLSVFVAIGEF-IYKSRKNNDIE 868

  Fly   845 QVALEERLTFKDAFKKEIRF 864
            |.....|:.|  .|:.::||
Human   869 QKGKSSRIRF--YFRNKVRF 886

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIICNP_608557.4 PBP1_iGluR_Kainate 26..404 CDD:107377 113/421 (27%)
Periplasmic_Binding_Protein_Type_1 <279..363 CDD:299141 21/103 (20%)
PBP2_iGluR_Kainate 423..794 CDD:270432 129/371 (35%)
Lig_chan 554..828 CDD:278489 96/273 (35%)
GRIK1NP_001317923.1 Periplasmic_Binding_Protein_Type_1 35..430 CDD:324556 114/431 (26%)
Periplasmic_Binding_Protein_Type_2 446..815 CDD:328725 130/376 (35%)
Glutamate binding. /evidence=ECO:0000250 531..533 0/1 (0%)