DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and GRID2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_011530195.2	Gene:	GRID2 / 2895	HGNCID:	4576	Length:	1035	Species:	Homo sapiens

Alignment Length:	916	Identity:	225/916 - (24%)
Similarity:	377/916 - (41%)	Gaps:	192/916 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTG----------IPHIEFDISDE----- 122
            :..:.:..|:|::.|:.|:          :.::.|.|.|          |||:....|..
Human    87 ATALPQKTCELMNQGILAL----------VSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRS 141

  Fly   123 --GIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDAD-DARAAARLQDLLQ---- 180
              |:.....|...||::.| ...|......:|..:.|:||.|.||:: |.|......|.:.
Human   142 GCGLTRSNRNDDYTLSVRP-PVYLHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGM 205

  Fly   181 ---LREVHN----------DVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEF 232
               |::|.|          |.:|:.:.::..|..         ||.:|...|......:....|.
Human   206 DVALQKVENNINKMITTLFDTMRIEELNRYRDTL---------RRAILVMNPATAKSFITEVVET 261

  Fly   233 GLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLV--NPDPPPYSLPYGYVTQRDNIV 295
            .|.....|..:.|.|.....::||        |..:..||.:  ...|.|.::..........|.
Human   262 NLVAFDCHWIIINEEINDVDVQEL--------VRRSIGRLTIIRQTFPVPQNISQRCFRGNHRIS 318

  Fly   296 YESSDPPRTLIHDL------IHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRY 354
            ....||......::      |:|.:.|.|.::...   ..||......:........:.|..||.
Human   319 STLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKK---LEDRKWHSMASLSCIRKNSKPWQGGRS 380

  Fly   355 LARLMK--GTSGVNNTNFRTSILQFDEDGQRITFNIEV----YDPLDGIGI-------------A 400
            :...:|  |.||:      |..|:|.|:|.....:.|:    |....|.|:             .
Human   381 MLETIKKGGVSGL------TGELEFGENGGNPNVHFEILGTNYGEELGRGVRKNERIRPQGSTGK 439

  Fly   401 IWDPRG---QITQLN---VDVKAQKKM---IYRVATRIGPPYFSYNETARELNLTGN-ALYQGYA 455
            ||...|   .:|.||   .|.|.:..|   :.||.|.:..|:...:|     |:.|. ..|||::
Human   440 IWPQLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLEEPFVMVSE-----NVLGKPKKYQGFS 499

  Fly   456 VDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVD 520
            :|::||::.::||.|......|.:||. .:|...|||::||::...|.:||..||||..|:..||
Human   500 IDVLDALSNYLGFNYEIYVAPDHKYGS-PQEDGTWNGLVGELVFKRADIGISALTITPDRENVVD 563

  Fly   521 FTVPFMQLGVSILAYKSPHVEKTLD--AYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWEN 583
            ||..:|...|.:|..::   |||:|  |.||||...:|..|..:|.::..|      :..::|.|
Human   564 FTTRYMDYSVGVLLRRA---EKTVDMFACLAPFDLSLWACIAGTVLLVGLL------VYLLNWLN 619

  Fly   584 PHPCNRDPEVLENQW---RIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTA 645
            |      |.:.....   .::|:.|....|.:..|.::...:...||....||:||:|:.:||||
Human   620 P------PRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTA 678

  Fly   646 NLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTY------NLLADSNETVYRLAFNLMNND 704
            |||||||.:::|.||.:|:|||.|.::.:||:...:.|      .|.....:::|...:.::|..
Human   679 NLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRS 743

  Fly   705 DPSAYTKDNL----EGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSVGEKFGEKHYAIAVP 763
            :.|   ::|:    .|:.:|:  .|:|.|:.:...|||  ..:.:|...::|....::.|.||:.
Human   744 NGS---ENNVLESQAGIQKVK--YGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQ 803

  Fly   764 FGAEYRSNLSVAILKLSERGELYDLKQKWW-KNPNASCFEEPDPDATPD-MTFEELRGIFYTLYA 826
            .|:.||...|..||:|.:.|::..||.||| ||.....:...|...... :..:...|:|..|.|
Human   804 HGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAA 868

  Fly   827 GILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRS 891
            ||:::..|.:.|              |:              ||.||    |:.:      |.:.
Human   869 GIVLSCFIAMLE--------------TW--------------WNKRK----GSRV------PSKE 895

  Fly   892 LDKSLD 897
            .||.:|
Human   896 DDKEID 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	76/392 (19%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	15/91 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	121/389 (31%)
		Lig_chan	554..828	CDD:278489	79/290 (27%)
GRID2	XP_011530195.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.790