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Protein Alignment GluRIIC and GRIA4

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	933	Identity:	269/933 - (28%)
Similarity:	421/933 - (45%)	Gaps:	115/933 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QRILLLGCMW----SAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAI----NGPE-SEQTM 58
            |.:||....|    .||      ...:.||..|..:   .::|:.....||    ..|. ||...
Human     7 QIVLLFSGFWGLAMGAF------PSSVQIGGLFIRN---TDQEYTAFRLAIFLHNTSPNASEAPF 62

  Fly    59 RFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEG 123
            ...|.:..::..: |..:....|.....||.||||...|.:...:...|::..|..|......||
Human    63 NLVPHVDNIETAN-SFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEG 126

  Fly   124 IQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ---LREVH 185
                  ..|..|.|.|:   |..|...::.::.|..|..:||.|  |..:.||.:::   ....|
Human   127 ------ESQFVLQLRPS---LRGALLSLLDHYEWNCFVFLYDTD--RGYSILQAIMEKAGQNGWH 180

  Fly   186 NDVVRVRKFHKDDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLET 248
            ...:.|..|: |..:|.:.:.:  |.|::.|:|||...|..:|......|...:..|..:.||..
Human   181 VSAICVENFN-DVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGF 244

  Fly   249 YTDHLEELAADNETFAVNITAARLLVNPDPPPYSL--PYGYVTQRDNIVYESSDPPRTLIHDLIH 311
            ....||.....    ..|:|..:|:....|....|  .:..:.||:   |..|:.|......|.:
Human   245 KDISLERFIHG----GANVTGFQLVDFNTPMVIKLMDRWKKLDQRE---YPGSETPPKYTSALTY 302

  Fly   312 DALQLFAQSWR-------------NASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGT- 362
            |.:.:.|:::|             ||.              |..|:....|..|..:.|.:|..
Human   303 DGVLVMAETFRSLRRQKIDISRRGNAG--------------DCLANPAAPWGQGIDMERTLKQVR 353

  Fly   363 -SGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIG---IAIWDPRGQ------ITQLNVDVKA 417
             .|:      |..:|||..|:|:.:.::|:: |...|   :..|:...:      :..|..|..|
Human   354 IQGL------TGNVQFDHYGRRVNYTMDVFE-LKSTGPRKVGYWNDMDKLVLIQDVPTLGNDTAA 411

  Fly   418 QKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGK 482
            .:.....|.|.:..||..|.:. .|: ..||..|:||.|||...||:|:|.:|....|.|.:||.
Human   412 IENRTVVVTTIMESPYVMYKKN-HEM-FEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGA 474

  Fly   483 LDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAY 547
            .|.:||.|||::||::...|.:.|..||||..|:..:||:.|||.||:||:..|....:..:.::
Human   475 RDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF 539

  Fly   548 LAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDW--ENPH-----PCNRDPEVLENQWRIHN 602
            |.|...|:|:.|:   |.|.|:.||   |:|.|..:|  |.|.     |.::.|    |::.|.|
Human   540 LDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHTEEPEDGKEGPSDQPP----NEFGIFN 597

  Fly   603 TGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLS 667
            :.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||||||..:|...|.:.:||:
Human   598 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA 662

  Fly   668 AQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLME 732
            .|.::.:||:..|||......|...||...:..|.:.:||.:|:...|||.||||::|.:.||:|
Human   663 KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE 727

  Fly   733 TTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNP 796
            :|..|| .:.:.||...||.....|.|.:|.|.|:..|:.:::|:|||||.|.|..||.|||.:
Human   728 STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYD- 791

  Fly   797 NASC--FEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFK 859
            ...|  .:....|.|..::...:.|:||.|..|:.:|.|:.:.||....:..|...:|||.:|.:
Human   792 KGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIR 856

  Fly   860 KEIRFVL--CVWNNRKPIVAGTP 880
            .:.|..:  .|..|.:.:....|
Human   857 NKARLSITGSVGENGRVLTPDCP 879

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.