Protein Alignment GluRIIC and GRIA2

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Alignment Length: 899
• Identity: 257/899 - (28%)
• Similarity: 409/899 - (45%)
• Gaps: 136/899 - (15%)

  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFF---YDDELELEKEFMTVVNAINGPESEQTMRFYPLIKR 66
            :||...:|...|...|  ..|.||..|   .|.|....:     |..:....||  .|..|.|..
Human     9 VLLSPVLWGLIFGVSS--NSIQIGGLFPRGADQEYSAFR-----VGMVQFSTSE--FRLTPHIDN 64

  Fly    67 LKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH 131
            |:..: |..:....|.....||.||||...|.:.:.:...|.:..:..|......:|      .|
Human    65 LEVAN-SFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG------TH 122

  Fly   132 QMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLL-------------QLRE 183
            ...:.:.|.   |..|...:::.:.|.||..:||:|  |..:.||.:|             .:..
Human   123 PFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSD--RGLSTLQAVLDSAAEKKWQVTAINVGN 182

  Fly   184 VHNDVVRVRKFHKDDDFRVMWK--SIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNL 246
            ::||       .||:.:|.:::  .::.||||:||||.:.:.::::.....|...:..|..:.||
Human   183 INND-------KKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL 240

  Fly   247 ETYTDHLEELAADNETFAVNITAARL----LVNPDPPPYS-------------LPYGYVTQRDNI 294
             .:|        |.:...:....|.:    :|:.|....|             .|..:.|   .|
Human   241 -GFT--------DGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTT---TI 293

  Fly   295 VYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLAR 357
            .|.|:         |.:||:|:..:::||   ....|:.:.|  ...|..|:....|..|..:.|
Human   294 KYTSA---------LTYDAVQVMTEAFRN---LRKQRIEISRRGNAGDCLANPAVPWGQGVEIER 346

  Fly   358 LMK-----GTSGVNNTNFRTSILQFDEDGQRITFNIEV-------------YDPLDGIGIAIWD- 403
            .:|     |.||         .::||::|:||.:.|.:             :..:|.:.:.:.:
Human   347 ALKQVQVEGLSG---------NIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTEL 402

  Fly   404 PRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGF 468
            |.|.      |....:.....|.|.:..||....:. .|: |.||..|:||.|||...||:|.||
Human   403 PSGN------DTSGLENKTVVVTTILESPYVMMKKN-HEM-LEGNERYEGYCVDLAAEIAKHCGF 459

  Fly   469 EYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSIL 533
            :|....|.|.:||..|.:||.|||::||::...|.:.|..||||..|:..:||:.|||.||:||:
Human   460 KYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIM 524

  Fly   534 AYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDWENPH-PCNRDPEVL 594
            ..|....:..:.::|.|...|:|:.|:   |.|.|:.||   |:|.|..:|.... ...|:.:..
Human   525 IKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHTEEFEDGRETQSS 586

  Fly   595 E--NQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKME 657
            |  |::.|.|:.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||||||..:|.
Human   587 ESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMV 651

  Fly   658 GSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRK 722
            ..|.:.:|||.|.::.:||:..|||......|...|:...:..|.:.:||.:.:...|||.||||
Human   652 SPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRK 716

  Fly   723 NRGDYMFLMETTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELY 786
            ::|.|.:|:|:|..|| .:.:.||...||.....|.|.||.|.|:..|:.:::|:|||||:|.|.
Human   717 SKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLD 781

  Fly   787 DLKQKWWKNP-NASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEF 839
            .||.|||.:. .....:....:.|..::...:.|:||.|..|:.:|.|:.:.||
Human   782 KLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	92/438 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	147/377 (39%)
		Lig_chan	554..827	CDD:459656	102/280 (36%)
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	90/428 (21%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	148/385 (38%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877