Protein Alignment GluRIIC and GRIA1

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001244950.1
• Gene: GRIA1 / 2890
• HGNCID: 4571
• Length: 916
• Species: Homo sapiens
• Alignment Length: 977
• Identity: 269/977 - (27%)
• Similarity: 433/977 - (44%)
• Gaps: 156/977 - (15%)

  Fly     2 WQRILLLGC----------MWSAFFMCRSRGQQINIGAF-FYDDELELEKEFMTVVNAINGPES- 54
            |..:|   |          :|..|    ...|.....|| |...:|....:.:..::.:|..:|
Human    21 WSNLL---CFLTPVKLHPEVWGLF----PNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSF 78

  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGI----PHI 115
            |.|.||                    |.....||.||||...:...:::...|.:..:    |..
Human    79 EMTYRF--------------------CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSF 123

  Fly   116 EFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ 180
            ..|.|          :|..|.|.|.   |..|...|:.::.|:||..:||||  |..:.||.:|.
Human   124 PVDTS----------NQFVLQLRPE---LQDALISIIDHYKWQKFVYIYDAD--RGLSVLQKVLD 173

  Fly   181 LREVHN-DVVRVRKF-HKDDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHI 241
            .....| .|..|... ..::.:|::::.:  :.||.||:|||...|..:|....:....|...|.
Human   174 TAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHY 238

  Fly   242 FLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQ--RDNIVYESSDPPRT 304
            .|.||......|.:.    :....|:|..:|:...|..|..:...:...  ||:...:...|..|
Human   239 ILANLGFMDIDLNKF----KESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKYT 299

  Fly   305 LIHDLIHDALQLFAQSWRNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNN 367
              ..|.:|.:::.|:::::   ....|:.:.|  ...|..|:....|..|..:.|.::      .
Human   300 --SALTYDGVKVMAEAFQS---LRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQ------Q 353

  Fly   368 TNFR--TSILQFDEDGQRITFNIEVYD-PLDGI-GIAIWD------PRGQITQLNVDVKAQKKMI 422
            ..|.  |..:||:|.|:|..:.:.|.: ..||| .|..|:      |.....|...|..:.:...
Human   354 VRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRT 418

  Fly   423 YRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKET 487
            |.|.|.:..||....:.|.:..  ||..|:||.|:|...||:|||:.|....|:|.:||..|.:|
Human   419 YIVTTILEDPYVMLKKNANQFE--GNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDT 481

  Fly   488 KQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFG 552
            |.|||::||::...|.:.:..||||..|:..:||:.|||.||:||:..|....:..:.::|.|..
Human   482 KAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 546

  Fly   553 GEVWIWIL---ISVFVMTFLKTIVARISKMDWENPH-PCNRDPEVLE--NQWRIHNTGWLTVASI 611
            .|:|:.|:   |.|.|:.||   |:|.|..:|.:.. ...||....:  |::.|.|:.|.::.:.
Human   547 YEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAF 608

  Fly   612 MTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGT 676
            |..||||.|||...|:....||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||
Human   609 MQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGT 673

  Fly   677 IYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HR 740
            :..|||......|...|:...:..|.:.:||.:.:...||:.||||::|.|.:|:|:|..|| .:
Human   674 LEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQ 738

  Fly   741 EQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFE--E 803
            .:.||...||.....|.|.||.|.|:..|:.:::|:|||:|:|.|..||.|||.: ...|..  .
Human   739 RKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYD-KGECGSGGG 802

  Fly   804 PDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCV 868
            ...|.|..::...:.|:||.|..|:.:|.|:.:.||             .:|...:.:.....|:
Human   803 DSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEF-------------CYKSRSESKRMKGFCL 854

  Fly   869 WNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGR 933
                              .|::|:::::       |...:.|:|        |:|:|||    |.
Human   855 ------------------IPQQSINEAI-------RTSTLPRNS--------GAGASSG----GS 882

  Fly   934 GE 935
            ||
Human   883 GE 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	91/406 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	142/377 (38%)
		Lig_chan	554..827	CDD:459656	101/281 (36%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..402	CDD:380613	94/419 (22%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	143/386 (37%)