DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Grin2d

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	997	Identity:	204/997 - (20%)
Similarity:	368/997 - (36%)	Gaps:	234/997 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SVTMQEHACDLID----NGVAAIFGPSSK--AASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH 131
            |:.:|  .|||:.    :||  :|...|:  |.:.|:..:...|.:|.:........:...|...
  Rat    95 SLVLQ--LCDLLSGLRVHGV--VFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKG 155

  Fly   132 QMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHK 196
            ...|.|..:.....:...::::.:.|..|..|    ..||... :..|...||..|...|...|:
  Rat   156 STFLQLGSSTEQQLQVIFEVLEEYDWTSFVAV----TTRAPGH-RAFLSYIEVLTDGSLVGWEHR 215

  Fly   197 ----------DDDFRVMWKSIRGERRVVL----DCEPNMLVELLNSSTEFGLTGQ-Y-------- 238
                      :.......:|:..:.|::.    :.||     :..::.|.||||. |
  Rat   216 GALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEP-----VFRAAEEAGLTGPGYVWFMVGPQ 275

  Fly   239 -----------------------NHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPP 280
                                   ..:|......:.|.|....|..  .||....|:.|:.
  Rat   276 LAGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWRDDLARRVAAG--VAVVARGAQALLR----- 333

  Fly   281 YSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQ-SWRNASFFYPD-------RMVVPRI 337
               .||::.:   :.::.....||...:.:|   :.|.. :|.|..:.:.:       .:||..:
  Rat   334 ---DYGFLPE---LGHDCRTQNRTHRGESLH---RYFMNITWDNRDYSFNEDGFLVNPSLVVISL 389

  Fly   338 TCDFAASGGRTWAM-------------------GRYLARLMKGTSGVNNTNFRTSILQFDEDGQR 383
            |.|      |||.:                   ||:|       ..|::|...| :...:|   |
  Rat   390 TRD------RTWEVVGSWEQQTLRLKYPLWSRYGRFL-------QPVDDTQHLT-VATLEE---R 437

  Fly   384 ITFNIEVYDPLDGIGIAIWDPRGQI---TQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNL 445
            ....:|..||:.|..|     |..:   :|||             .|...||.....|
  Rat   438 PFVIVEPADPISGTCI-----RDSVPCRSQLN-------------RTHSPPPDAPRPE------- 477

  Fly   446 TGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLT 510
              ....:|:.:|::..:|..:||.|....|.:.::||  |....|||:|||:....|.|.|..||
  Rat   478 --KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGK--KIDGVWNGMIGEVFYQRADMAIGSLT 538

  Fly   511 ITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLA-----------PFGGEVWIW------ 558
            |.:.|...|||:|||::.|:|::..:| :...:..|:||           |:...||:.
  Rat   539 INEERSEIVDFSVPFVETGISVMVARS-NGTVSPSAFLAFAWLTPPMSPEPYSPAVWVMMFVMCL 602

  Fly   559 --ILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDI-LP 620
              :.::||:..:|..:....|....:.|.         .:.:.|..:.||..|.:......: .|
  Rat   603 TVVAVTVFIFEYLSPVGYNRSLATGKRPG---------GSTFTIGKSIWLLWALVFNNSVPVENP 658

  Fly   621 RSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQK------KVKFGTIYG 679
            |....::....|..||:|...|||||||||:...:...:::.|.|...|:      .:||||:..
  Rat   659 RGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPN 723

  Fly   680 GSTYNLLADSNETV--YRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY--HR 740
            |||...:..:...:  |.:.:|....:          |.:.:::..:.| .|:.:...|.|  .:
  Rat   724 GSTEKNIRSNYPDMHSYMVRYNQPRVE----------EALTQLKAGKLD-AFIYDAAVLNYMARK 777

  Fly   741 EQNCDLRSV--GEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEE 803
            ::.|.|.::  |:.|....|.||:..|:.::..:.:|:|:.....|:..|::.|.   :..|..:
  Rat   778 DEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWL---SGICHND 839

  Fly   804 PDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQ---VALEERLTFKDAFKKEIRFV 865
            .....:..:..:.:.|:||.|...:.::.|:...|.|||.:.   :....|:.|..||.:.: :.
  Rat   840 KIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGM-YS 903

  Fly   866 LCVWNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNN 930
            .|......|.....|......:|.....:.   .|..:..|...|::.:....|:|:|...|:..
  Rat   904 CCSAEAAPPPAKPPPPPQPLPSPAYPAARP---PPGPAPFVPRERAAADRWRRAKGTGPPGGAAI 965

  Fly   931 A-------------GRGEKEAR 939
            |             |.|..|||
  Rat   966 ADGFHRYYGPIEPQGLGLGEAR 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	73/409 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/110 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	96/402 (24%)
		Lig_chan	554..828	CDD:278489	61/294 (21%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601	60/350 (17%)
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	109/467 (23%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349727
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840