Protein Alignment GluRIIC and Grin2c

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_017452477.1
• Gene: Grin2c / 24411
• RGDID: 2739
• Length: 1250
• Species: Rattus norvegicus
• Alignment Length: 1012
• Identity: 222/1012 - (21%)
• Similarity: 382/1012 - (37%)
• Gaps: 246/1012 - (24%)

  Fly    43 MTVVNAINGPESEQ------TMRFYPLIKRLKP--------EDGSVTMQEHACDLIDNGVAAIFG 93
            :.||...:||...|      :..|..|...::|        ...|:..|  .|.|:  |.|.:.|
  Rat    45 VAVVFGSSGPLQTQARTRLTSQNFLDLPLEIQPLTVGVNNTNPSSILTQ--ICGLL--GAARVHG 105

  Fly    94 ------PSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEK-PNH---QMTLNLYPAQAILSKAY 148
                  ..::|.:.::..|.:.|.:|.:........:...| |..   |:.::|.....:|.|
  Rat   106 IVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFK-- 168

  Fly   149 ADIVQNFGWRKFTIVYD---------------ADDARAAARLQDLLQLR-EVHNDVVRVRKFHKD 197
              :::.:.|..|.::..               ||.:..:.||.|:|.|. .......|.::..:.
  Rat   169 --VLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQ 231

  Fly   198 DDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLT-NLETYTDHLEELAADNE 261
            .|..|:          |..|.......|...:.:.||.|. .|::|. ||
  Rat   232 VDAPVL----------VAYCSREEAEVLFAEAAQAGLVGP-GHVWLVPNL--------------- 270

  Fly   262 TFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDA---LQLFAQSWRN 323
                      .|.:.|.||.:.|.|.:    ::|.||.   |..:...:.|.   |.|.|.|:|.
  Rat   271 ----------ALGSTDAPPAAFPVGLI----SVVTESW---RLSLRQKVRDGVAILALGAHSYRR 318

  Fly   324 ----------------------ASFFYPDRMVVPRITCDFAASGG----------------RTWA 350
                                  ...||...:.|.....||:.|.|                |.|.
  Rat   319 QYGTLPAPAGDCRSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVRPTMVVIALNRHRLWE 383

  Fly   351 M-GRYLARLMKGTSGVNNTNF-----RTSILQFDEDGQRITFN---------IEVYDPLDGIGIA 400
            | ||:       ..||....:     .::.||...|.:.:|..         :|..||  |.|..
  Rat   384 MVGRW-------DHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDP--GTGGC 439

  Fly   401 IWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLT--GNALYQGYAVDLIDAIA 463
            :  |.      .|..:.|.                 |.|....:||  .....:|:.:|::..:|
  Rat   440 V--PN------TVPCRRQS-----------------NHTFSSGDLTPYTKLCCKGFCIDILKKLA 479

  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528
            :.|.|.|....|.:.::||  :....|||:|||:....|.|.|..|||.:.|...:||:|||::.
  Rat   480 KVVKFSYDLYLVTNGKHGK--RVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVET 542

  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEV 593
            |:|::..:| :...:..|:|.|:...||    :.:|||..  |:|| |:...:|...|.:.:..:
  Rat   543 GISVMVSRS-NGTVSPSAFLEPYSPAVW----VMMFVMCL--TVVA-ITVFMFEYFSPVSYNQNL 599

  Fly   594 LENQ------WRIHNTGWLTVASIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTANLAAFL 651
            .:.:      :.|..:.||..|.:......| .||....::....|..||:|...|||||||||:
  Rat   600 TKGKKPGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFM 664

  Fly   652 TSSKMEGSIANLKDLSAQK------KVKFGTIYGGST-YNLLADSNET-VYRLAFNLMNNDDPSA 708
            ...:...:::.|.|...|:      ..:|||:..||| .|:.::..:. .:.:.||..:.:|  |
  Rat   665 IQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVED--A 727

  Fly   709 YTKDNLEGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSV--GEKFGEKHYAIAVPFGAEYR 769
            .|...:..:|         .|:.:...|.|  .:::.|.|.::  |:.|....|.||:...:.::
  Rat   728 LTSLKMGKLD---------AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK 783

  Fly   770 SNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLI 834
            ..:.:|:|:|...||...|:..|.   :..|..|.:...:..:..:.:.|:||.|...:.:|.|:
  Rat   784 RAIDLALLQLLGDGETQKLETVWL---SGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 845

  Fly   835 GITEFLVYVQ---QVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSL 896
            ...|.|||.:   .|....:|.|..||.:.|  ..|             .:.|::.|..:...|.
  Rat   846 FAWEHLVYWKLRHSVPNSSQLDFLLAFSRGI--YSC-------------FNGVQSLPSPARPPSP 895

  Fly   897 DRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGR 933
            |.|..|::..|: :..:..|:|...:..||..:.|.|
  Rat   896 DLTADSAQANVL-KMLQAARDMVNTADVSSSLDRATR 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	87/462 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	101/391 (26%)
		Lig_chan	554..827	CDD:459656	70/291 (24%)
Grin2c	XP_017452477.1	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	77/409 (19%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	111/450 (25%)
		NMDAR2_C	850..>925	CDD:463148	20/90 (22%)