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Protein Alignment GluRIIC and Grin2a

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_036705.3	Gene:	Grin2a / 24409	RGDID:	2737	Length:	1464	Species:	Rattus norvegicus

Alignment Length:	953	Identity:	199/953 - (20%)
Similarity:	374/953 - (39%)	Gaps:	195/953 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LIKRLKPEDGSVTMQEHACDLID----NGVAAIFGPSS--KAASDIVALVCNSTGIPHIEFDISD 121
            |:.|..|:    ::..|.|||:.    :|:  :||..:  :|.:.::..:.:.|.||.:......
  Rat    73 LMNRTDPK----SLITHVCDLMSGARIHGL--VFGDDTDQEAVAQMLDFISSQTFIPILGIHGGA 131

  Fly   122 EGIQAEK-PN---HQMTLNLYPAQAILSKAYADIVQNFGWRKFTIV---------------YDAD 167
            ..|.|:| |.   .|...::.....::.|    |:|::.|..|::|               ...|
  Rat   132 SMIMADKDPTSTFFQFGASIQQQATVMLK----IMQDYDWHVFSLVTTIFPGYRDFISFIKTTVD 192

  Fly   168 DARAAARLQDLLQLREVHNDV---VRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSS 229
            ::.....:|:::.|.....|.   |:::|.|         .|:     ::|.|..:..|.:|:.:
  Rat   193 NSFVGWDMQNVITLDTSFEDAKTQVQLKKIH---------SSV-----ILLYCSKDEAVLILSEA 243

  Fly   230 TEFGLTGQYNHIFLTNLETYTDHLEELAADN-ETFAVNITAARLLVNPDPPPYSL---------- 283
            ...|||| |:..::         :..|.:.| |.......:..:.|:.|...|||
  Rat   244 RSLGLTG-YDFFWI---------VPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGI 298

  Fly   284 ----------PYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRIT 338
                      .:.|:.:.....|..::.|.|.:|.| |..:.......::.||......|.||:.
  Rat   299 LTTAASSMLEKFSYIPEAKASCYGQAEKPETPLHTL-HQFMVNVTWDGKDLSFTEEGYQVHPRLV 362

  Fly   339 CDFAASGGRTW-AMGRYLARLM----------KGTSGVNNTNFRTSILQFDEDGQRITFNIEVYD 392
            . ...:..|.| .:|::..:.:          |..|.....:...||:..:|....|   :|..|
  Rat   363 V-IVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVI---VEDID 423

  Fly   393 PLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVD 457
            ||....:....|..:..::|                        |.|...:|:  ....:|:.:|
  Rat   424 PLTETCVRNTVPCRKFVKIN------------------------NSTNEGMNV--KKCCKGFCID 462

  Fly   458 LIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFT 522
            ::..::|.|.|.|....|.:.::||  |....|||:|||::...|.|.:..|||.:.|...|||:
  Rat   463 ILKKLSRTVKFTYDLYLVTNGKHGK--KVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFS 525

  Fly   523 VPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPC 587
            |||::.|:|::..:| :...:..|:|.||...||:.:.:.:.:::.:...|     .::.:|...
  Rat   526 VPFVETGISVMVSRS-NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFV-----FEYFSPVGY 584

  Fly   588 NRD---------PEVLENQWRIHNTGWLTVASIMTAGCDIL-PRSPQVRMFEATWWIFAIIIANS 642
            ||:         |     .:.|....||....:......:. |:....::..:.|..||:|...|
  Rat   585 NRNLAKGKAPHGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLAS 644

  Fly   643 YTANLAAFLTSSKMEGSIANLKDLSAQK------KVKFGTIYGGSTYNLLADSNETVYRLAFNLM 701
            ||||||||:...:....:..|.|...|:      ..:|||:..|||..              |:.
  Rat   645 YTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTER--------------NIR 695

  Fly   702 NNDDPSAY---TKDNLEGVD----RVRKNRGDYMFLMETTTLEYH--REQNCDLRSVGEK--FGE 755
            || .|..:   |:.|..||:    .::..:.| .|:.:...|.|.  |::.|.|.::|..  |..
  Rat   696 NN-YPYMHQYMTRFNQRGVEDALVSLKTGKLD-AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758

  Fly   756 KHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGI 820
            ..|.||:..|:.::..:.:|:|:....||:.:|:..|.   ...|..|.:...:..:..:.:.|:
  Rat   759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL---TGICHNEKNEVMSSQLDIDNMAGV 820

  Fly   821 FYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVR 885
            ||.|.|.:.::.:..|.|.|.|     .:.|..|..........:..:.......:.|..|...:
  Rat   821 FYMLAAAMALSLITFIWEHLFY-----WKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKK 880

  Fly   886 TTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGS 928
            .:|..:|      |...|..:.:.||::.:..|:..:.|...|
  Rat   881 KSPDFNL------TGSQSNMLKLLRSAKNISNMSNMNSSRMDS 917

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.