Protein Alignment GluRIIC and Grin1

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001257531.1
• Gene: Grin1 / 24408
• RGDID: 2736
• Length: 959
• Species: Rattus norvegicus
• Alignment Length: 1042
• Identity: 244/1042 - (23%)
• Similarity: 415/1042 - (39%)
• Gaps: 237/1042 - (22%)

  Fly     6 LLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPE 70
            ||..|   :|.......:.:||||..  ...:.|:.|...||..|.......::........||
  Rat    11 LLFSC---SFARAACDPKIVNIGAVL--STRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKP- 69

  Fly    71 DGSVTMQEHAC-DLIDNGVAAIF-----GPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKP 129
             .::.|....| |||.:.|.||.     .|:.......|:.......||.:.. .:...|.::|.
  Rat    70 -NAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGL-TTRMSIYSDKS 132

  Fly   130 NHQMTLNLYPAQAILSKAYADIVQNFGWRK-FTIVYDADDARAA-ARLQDLLQLREVHNDVVRVR 192
            .|...|...|..:..|..:.::::.:.|.. ..:|.|..:.||| .||:.||:.||..:   :.|
  Rat   133 IHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKS---KKR 194

  Fly   193 KFHKDDDFRVMWKSIRGER-RVVLDCEPN------MLVE--------LLNSSTEFGLTGQYNHIF 242
            .:...|  ::.:.:.||.: ..||..:|.      :|:|        ::.|::|......|....
  Rat   195 NYENLD--QLSYDNKRGPKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAA 257

  Fly   243 LTNLETYTDHL-----EELAADNETFAVNITAARLLVN--PDPPPYSLPYGYVTQ-------RDN 293
            :.|: |.:.::     .|::.:...:|.:......|:|  .:....|...|.|.|       ::|
  Rat   258 MLNM-TGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKEN 321

  Fly   294 IVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRT--WAMGRYLA 356
            |    :||||..:                                       |.|  |..|....
  Rat   322 I----TDPPRGCV---------------------------------------GNTNIWKTGPLFK 343

  Fly   357 RLM---KGTSGVNNTNFRTSILQFDEDGQRITFNIEVYD----PLDGIGI------------AIW 402
            |::   |...||      |..::|:|||.|...|..:.:    .|..:||            .||
  Rat   344 RVLMSSKYADGV------TGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIW 402

  Fly   403 ------DPRG--QITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQ------- 452
                  .|||  ..|:|.:....|:..:|      ..|..|......|..:.|:.:.:
  Rat   403 PGGETEKPRGYQMSTRLKIVTIHQEPFVY------VKPTMSDGTCKEEFTVNGDPVKKVICTGPN 461

  Fly   453 ----------------GYAVDLIDAIARHVGFEYVFVPVADQQYGKLDK----ETKQWNGIIGEI 497
                            |:.:||:..:||.:.|.|....|||.::|..::    ..|:|||::||:
  Rat   462 DTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGEL 526

  Fly   498 INNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKS-PHVEKTLDAYLAPFGGEVWIWILI 561
            ::..|.|.:..|||...|...::|:.||...|::||..|. |  ..|||:::.||...:|:.:.:
  Rat   527 LSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIP--RSTLDSFMQPFQSTLWLLVGL 589

  Fly   562 SVFVMTFLKTIVARISKMDWENPHPCNR----DPEVLENQWRIHNTGWLTVASIMTAGC-DILPR 621
            ||.|:..:..::.|.|        |..|    ..|..|:...:.:..|.:...::.:|. :..||
  Rat   590 SVHVVAVMLYLLDRFS--------PFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPR 646

  Fly   622 SPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKD---LSAQKKVKFGTIYGGST- 682
            |...|:....|..||:||..||||||||||...:.|..|..:.|   .:...|..:.|:...|.
  Rat   647 SFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVD 711

  Fly   683 -YNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDL 746
             |........|:||   ::..::..||     .|.:..||.|: .:.|:.::..||:...|.|||
  Rat   712 IYFRRQVELSTMYR---HMEKHNYESA-----AEAIQAVRDNK-LHAFIWDSAVLEFEASQKCDL 767

  Fly   747 RSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPD--PDAT 809
            .:.||.|....:.|.:...:.::.|:|::|||..|.|.:.||.:.|.:      ::|.|  .:|.
  Rat   768 VTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVR------YQECDSRSNAP 826

  Fly   810 PDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLC---VW-- 869
            ..:|||.:.|:| .|.||.::|   ||  ||::: ::|.:..   |||.:|:::....   ||
  Rat   827 ATLTFENMAGVF-MLVAGGIVA---GI--FLIFI-EIAYKRH---KDARRKQMQLAFAAVNVWRK 881

  Fly   870 --NNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAG 932
              .:||         |.|..|        |...|::.|.:....:...:.......:|:|   .|
  Rat   882 NLQDRK---------SGRAEP--------DPKKKATFRAITSTLASSFKRRRSSKDTSTG---GG 926

  Fly   933 RG 934
            ||
  Rat   927 RG 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	92/448 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	109/408 (27%)
		Lig_chan	554..827	CDD:459656	77/284 (27%)
Grin1	NP_001257531.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	89/438 (20%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	113/434 (26%)
		CaM_bdg_C0	856..884	CDD:402271	7/30 (23%)