Protein Alignment GluRIIC and Grik5

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_006228444.1
• Gene: Grik5 / 24407
• RGDID: 2735
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 897
• Identity: 256/897 - (28%)
• Similarity: 428/897 - (47%)
• Gaps: 104/897 - (11%)

  Fly    71 DGSVTMQEHACDLIDNGVAAIFGPSSKAAS-DIVALVCNSTGIPHIEFDISDEGIQAEKPNHQ-- 132
            |......:..|.::..||.::.||||..|| ..|:.:|....||||:  :..|    |.|..|
  Rat    73 DSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK--VGPE----ETPRLQYL 131

  Fly   133 --MTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFH 195
              .:::|||:...:|.|.:.|:::|.:...:::  ...|....||::|::...:..:.:.||...
  Rat   132 RFASVSLYPSNEDVSLAVSRILKSFNYPSASLI--CAKAECLLRLEELVRGFLISKETLSVRMLD 194

  Fly   196 KDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAA 258
            ...|...:.|.||.::  .:::|...::...:|..::|.|:|..:....||.::....||:.:..
  Rat   195 DSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVE 259

  Fly   259 DNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFA 318
            |:.    ||....:. |...|.|     ||...:   |:| ...|:.|...|...|:.||:.:..
  Rat   260 DSS----NILGFSMF-NTSHPFYPEFVRSLNMSW---REN-CEASTYPGPALSAALMFDAVHVVV 315

  Fly   319 QSWR--NASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGT--SGVNNTNFRTSILQFDE 379
            .:.|  |.|    ..:.|..:.|    :....|..|..|...::..  .|:      |..::|:.
  Rat   316 SAVRELNRS----QEIGVKPLAC----TSANIWPHGTSLMNYLRMVEYDGL------TGRVEFNS 366

  Fly   380 DGQRITFNIEVYDPLDGIG---IAIWDPRGQI----TQLNVDVK---AQKKMIYRVATRIGPPYF 434
            .|||..:.:.:.:. ...|   |.:|.....:    |.|::::.   |.|.::  |.|.:..||
  Rat   367 KGQRTNYTLRILEK-SRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLV--VTTILENPY- 427

  Fly   435 SYNETARELN---LTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGE 496
                ..|..|   |:||..::|:.||::..:|..:.|.|....|.|..|| ..:....|.|::||
  Rat   428 ----VMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYG-APEPNGSWTGMVGE 487

  Fly   497 IINND-AHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT--LDAYLAPFGGEVWIW 558
            :||.. |.:.:...|||..|:..:||:.|||.||:||| |: .|:.:.  ..::|.||...||::
  Rat   488 LINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISIL-YR-VHMGRKPGYFSFLDPFSPAVWLF 550

  Fly   559 ILISVFVMTFLKTIVARISKMDWENPHPCNR-DPEVLENQWRIHNTGWLTVASIMTAGCDILPRS 622
            :|::...::.:..:.||:|..:|.|||||.| .|.:||||:.:.|:.|..|...|..|.:|:||:
  Rat   551 MLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRA 615

  Fly   623 PQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLA 687
            ...|.....||.|.:||.:|||||||||||..:||..:.:..||:.|..:::|||:.|||.....
  Rat   616 LSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQ 680

  Fly   688 DSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEK 752
            :|....|:..:|.|.:..||.:.|...||:.||..:|  |.||:|:|..||||..||:|..:|..
  Rat   681 NSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGGL 743

  Fly   753 FGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEEL 817
            ...|.|.|.:|.|:.:|..:::|||:|.|...|..||:|||:  ...|.:|.|..| ..:..|.:
  Rat   744 LDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE--GGRCPKEEDHRA-KGLGMENI 805

  Fly   818 RGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPIS 882
            .|||..|..|::||..:.:.||:...::.|..|.::......:|:|..:
  Rat   806 GGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAV---------------- 854

  Fly   883 SVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMR-----EMAQGSGSSSGSN 929
            |.|.|.|   .:...|....||.::..|:..|||     ..:.|:|..:|::
  Rat   855 SCRKTSR---SRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAH 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	79/360 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	140/377 (37%)
		Lig_chan	554..827	CDD:459656	105/273 (38%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	79/359 (22%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	141/382 (37%)