Protein Alignment GluRIIC and Grik4

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_036704.1
• Gene: Grik4 / 24406
• RGDID: 2734
• Length: 956
• Species: Rattus norvegicus
• Alignment Length: 964
• Identity: 263/964 - (27%)
• Similarity: 438/964 - (45%)
• Gaps: 104/964 - (10%)

  Fly     6 LLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEK-EFMTVV---NAIN-GPE----SEQTMRFY 61
            |:|...|.....|.....:|   |...||.:|..: |.:::.   |.|| .||    ::..:..:
  Rat     8 LVLLPAWLLMVACSPHSLRI---AAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIF 69

  Fly    62 PLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSK-AASDIVALVCNSTGIPHIEFDISDEGIQ 125
            .|::     |......|..|.::..||.|:.||||. |:|.|::.:|....:||  |.::.|...
  Rat    70 ELLR-----DSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFV 127

  Fly   126 AEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVR 190
            ..:.....||||:|:...:|.|.|.|:..|......::  ...|.....|:.||:...:..|.:.
  Rat   128 RFQLQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLI--CAKAECLLNLEKLLRQFLISKDTLS 190

  Fly   191 VRKFHKDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHL 253
            ||......|...:.|.||.::  .:::....:|...:|..:.|.|:...|.....||||.....:
  Rat   191 VRMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRM 255

  Fly   254 EELAADNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIVYESSDPPRTLIHDLIHDA 313
            :.|..|.    |||....:. |.....:     ||...:....|::.:........|:.|.::..
  Rat   256 DSLVDDR----VNILGFSIF-NQSHAFFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAV 315

  Fly   314 LQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMG----RYLARL-MKGTSG-------VN 366
            :....:..|:      ..:.|..::|..|    :.|..|    .||..: ::|.:|       ..
  Rat   316 VTAVQELNRS------QEIGVKPLSCGSA----QIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQ 370

  Fly   367 NTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGP 431
            .:|:...||||..:|.|   .|..:...:|:.:   |.|...:.:: |......::  |.|.:..
  Rat   371 RSNYALKILQFTRNGFR---QIGQWHVAEGLSM---DSRLYASNIS-DSLFNTTLV--VTTILEN 426

  Fly   432 PYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGE 496
            ||.......:::.  ||..|:|:.||::..:|..:.|.|....|.|..|| :.:....|.|::||
  Rat   427 PYLMLKGNHQDME--GNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYG-VPEANGTWTGMVGE 488

  Fly   497 IINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT--LDAYLAPFGGEVWIWI 559
            :|...|.:.:..||||..|:..:||:.|||.||:||| |: .|:.:.  ..::|.||...||:::
  Rat   489 LIARKADLAVAGLTITAEREKVIDFSKPFMTLGISIL-YR-VHMGRRPGYFSFLDPFSPGVWLFM 551

  Fly   560 LISVFVMTFLKTIVARISKMDWENPHPCNRDP-EVLENQWRIHNTGWLTVASIMTAGCDILPRSP 623
            |::...::.:..:|||::..:|.:||||.:.. .:|.||:.:.|:.|..|...|..|..|.||:.
  Rat   552 LLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRAL 616

  Fly   624 QVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLAD 688
            ..|.....||.|.:||.:|||||||||||..:||..|.::.||:.|..:::|||:|||:.....:
  Rat   617 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQN 681

  Fly   689 SNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKF 753
            |....|:..:|.|.:..||.:.|...||:.||..:  :|.||:|:|..||:|::||:|..:|...
  Rat   682 SRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQRNCNLTQIGGLL 744

  Fly   754 GEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELR 818
            ..|.|.|.:|.|:.:|....:|||:|.|...|..||:|||:  ...|.:|.|..| ..:..|.:.
  Rat   745 DTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE--GGKCPKEEDHRA-KGLGMENIG 806

  Fly   819 GIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISS 883
            |||..|..|:::|..:.:.|||..::.....|....::...:....:||..|
  Rat   807 GIFVVLICGLIVAIFMAMLEFLWTLRHSEASEVSVCQEMMTELRSIILCQDN------------- 858

  Fly   884 VRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSGSSSGSNNAGRGEKE 937
              ..|||.....|...|.     |:    ||.|  .:|:.:.|.....|.||.:
  Rat   859 --IHPRRRRSGGLPPQPP-----VL----EERR--PRGTATLSNGKLCGAGEPD 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	91/411 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	133/373 (36%)
		Lig_chan	554..827	CDD:459656	100/273 (37%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	90/410 (22%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	133/378 (35%)
		QRL_CxxC_CxxC	863..927	CDD:469521	12/48 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956