DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Grin3a

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001263284.1	Gene:	Grin3a / 242443	MGIID:	1933206	Length:	1135	Species:	Mus musculus

Alignment Length:	944	Identity:	200/944 - (21%)
Similarity:	364/944 - (38%)	Gaps:	211/944 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWQRILLLGCMWSAFFMCRSRGQQIN--IGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPL 63
            :|.|..||..:           :.:|  .|...|:..||       ||.||     |..:...||
Mouse   122 LWPRDALLFAV-----------ENLNRVEGLLPYNLSLE-------VVMAI-----EAGLGDLPL 163

  Fly    64 IKRLKP-----EDGSVTMQEHACDLIDNGVAAIFG-PSSKAASDIVALVCNSTGIPHIEFDISDE 122
            :....|     .|....:|.....::..||:|:.. |.|:.....:.||.:...||.:.....:.
Mouse   164 MPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEF 228

  Fly   123 GIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHND 187
            ..:::.|.| :.|:|..:.:..:.....|:....|..|:::...:|    ..:.|.|.|.|.::
Mouse   229 PRESQNPLH-LQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQED----WNITDFLLLTENNS- 287

  Fly   188 VVRVRKFH--------------KD--DDFRVMWKSIRGE--RRVVLDCEPNMLVELLNSSTEFGL 234
                 |||              ||  ...:|..::||..  ..|:..|:...:.::...||:|||
Mouse   288 -----KFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGL 347

  Fly   235 TGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESS 299
            :....|..|.:    :.::|||..:                      .||.|.:..        .
Mouse   348 SPPDLHWVLGD----SQNVEELRTE----------------------GLPLGLIAH--------G 378

  Fly   300 DPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVP-RITCDFAASGGRTWAMGRYLARLMKGTS 363
            ...:::....:.||::|.|::...|:...|:..::| .:.|....:...|  .|:||:|.:.
Mouse   379 KTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLT--SGQYLSRFLA--- 438

  Fly   364 GVNNTNFRTSILQFDEDGQRIT--------FNIEVYDPLDGIGIAIWDPRG--QITQLNVD---- 414
               ||.||.........|..|.        :|:: |||:   |..:|...|  |..::.:|
Mouse   439 ---NTTFRGLSGSIKVKGSTIVSSENNFFIWNLQ-YDPM---GKPMWTRLGSWQGGRIVMDSGIW 496

  Fly   415 -VKAQK---------KMIYRVATRIGPPYFSYNETARE-------------------LNLTGNAL 450
             .:||:         |:..||.|.|..|:....|...|                   |:...::|
Mouse   497 PEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSL 561

  Fly   451 YQ--------------GYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINND 501
            :.              ||.:||::.:|..:.|::....|.|.:||..  :...|.|::|::::..
Mouse   562 HSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVGDLLSGT 624

  Fly   502 AHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVM 566
            |:|.:...:|..||...:|||.||....:.||. ::......:.|::.|....:|:.|.:::.:.
Mouse   625 ANMAVTSFSINTARSQVIDFTSPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFVALHIT 688

  Fly   567 TFLKTIVARISKMDWENPH---PCNRDPEVLENQWRIHN-TGWLTVASIMTAGCDILPRSPQV-- 625
            ....|:      .:|::|.   |..|      |:.::.: :..|.|...:..|.....:.|:.
Mouse   689 AIFLTL------YEWKSPFGMTPKGR------NRNKVFSFSSALNVCYALLFGRTAAIKPPKCWT 741

  Fly   626 -RMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLS---AQKKVKFGTIYGGSTYNLL 686
             |.....|.||.:...::|||||||.:...|:...::.:.|..   ..:..:|||:...|..:.:
Mouse   742 GRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYV 806

  Fly   687 ADSNETV--YRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYH--REQNCDLR 747
            ..|...:  |...:|:....|...|.|::.|.:|         .|:|:...|:|.  .:.:|.|.
Mouse   807 RQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLD---------AFIMDKALLDYEVSIDADCKLL 862

  Fly   748 SVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK----NPNASCFEEPDPDA 808
            :||:.|..:.|.|.:|..:...||:|..|.:....|.:..|..||:|    ...:....|
Mouse   863 TVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTE----- 922

  Fly   809 TPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY 842
            |..|..:...|:|..|..|..::.|..|.|.:||
Mouse   923 TLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVY 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	84/412 (20%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	16/84 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	93/417 (22%)
		Lig_chan	554..828	CDD:278489	64/291 (22%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	91/454 (20%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	93/419 (22%)
		Lig_chan	676..942	CDD:278489	64/291 (22%)
		PPP2CB binding site. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	951..987		3/6 (50%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840