DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and glr-6

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	858	Identity:	219/858 - (25%)
Similarity:	370/858 - (43%)	Gaps:	126/858 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LEKEFMTVVNAINGPESEQTMR-----FYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSK 97
            ||....|.||.|....:||.::     |......:..::....:....|||.::.|:.|.|...:
Worm    30 LEHSVRTAVNIIVPRINEQIVKTRGACFITHTSFIALKNSHEDLNTKICDLANSEVSVIIGVVDR 94

  Fly    98 AASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQN----FGWR 158
            .:..|:...|....|..|.: ....|.|.::   |.:|||||     |..|:.:::.    :.|.
Worm    95 ESGSIIEEQCAELNILFIHY-YWTPGYQKKQ---QTSLNLYP-----SMEYSQLMERLINLWRWD 150

  Fly   159 KFTIVYDADDA-----RAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRG--------- 209
            .|..:|...||     ...:||:....|...|.         .||.......::|.
Worm   151 NFVYIYSNYDAPKQLIETLSRLEKSPALLRAHT---------LDDSMMATALALRDTCDRNRCWP 206

  Fly   210 -ERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLL 273
             :.||:::..||..:...::|.:.|:...:|...:|.|:...|||.:...:....:: :|.::..
Worm   207 KKNRVLIELSPNETLTFFDASLKLGMISVHNWFLITALDDLNDHLSQYTHNGMRVSL-LTVSKEK 270

  Fly   274 VNPDPPPYSLPYGYVTQRDNIVYESSDP--PRTLIHD--LIHDALQLFAQSWRNASFFYPDRMVV 334
            .|.:.....||..|..      |.:..|  |||...|  .|.|::.|..|:        .||.:
Worm   271 WNQNDLAIKLPDMYQE------YLAKIPSNPRTPFKDFAFIFDSILLACQA--------GDRRI- 320

  Fly   335 PRITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVYD-PLDGIG 398
              |:|      |...|:.::...::|...|:      |..:.|:....|....:.::: .:.|.|
Worm   321 --ISC------GDNEAVKKFKLPIVKPFKGL------TGKISFNGTSDRSDSELHIWEMGITGAG 371

  Fly   399 I------AIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLT----------- 446
            :      :.|:...::|.|..::....:. |:.:.|          .:|.|.:|
Worm   372 LHTGIWKSTWEGSKELTMLAKNIPGTHEH-YQASVR----------ESRTLKVTSIHEKPYVIEK 425

  Fly   447 ----GNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGIC 507
                |...::|:.|||:|.:|..:.|.|....|.|.:||:....|.:|:|:||||:..||.|.:.
Worm   426 IMPDGRIKHEGFCVDLLDKLAEMLHFNYTLKIVKDNKYGERKNGTDEWDGMIGEILRGDADMAVA 490

  Fly   508 DLTITQARKTAVDFTVPFMQLGVSILAYK-SPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKT 571
            .:|:|..|...:|||.||:|||:|:|..: :|....:|..:|.|....||.:..|:..:...|.|
Worm   491 PITVTATRLEVIDFTDPFLQLGISMLMRQPNPKSSSSLTRFLWPLSASVWTFSAIATVITALLVT 555

  Fly   572 IVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFA 636
            :.|.:|             |:....:::|.|:.|..|..::.||.....::...|:..|.||.|.
Worm   556 VAAVLS-------------PKESTAEFKIQNSVWYLVCILLRAGSGYNCQAGATRLISAVWWSFT 607

  Fly   637 IIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLM 701
            :::...||||.||.||..:......:.::|..|.:..||:|.||||......|....:|..:..|
Worm   608 LVLIAQYTANFAALLTVDRKSMPFNSFEELGNQTEYNFGSILGGSTMQFFKYSRIETFRRLWERM 672

  Fly   702 NNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGE-KFGEKHYAIAVPFG 765
            .:.:|||:...|.|||:||...:  |:||||:.||:|...|||:|..||. ..|...|:||:|.|
Worm   673 QSAEPSAFVGTNHEGVNRVLNEK--YVFLMESATLDYQVTQNCNLTRVGNVVLGSNGYSIALPKG 735

  Fly   766 AEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILI 830
            :::|..|:..||.|:|:|.:..||..|||.....|......|....:..|.:.|:|..|..|..|
Worm   736 SKWREKLTRQILDLNEKGIILMLKNNWWKKSQQECQSSEPEDLQTALGAENVYGLFLLLALGSGI 800

  Fly   831 AFLIGITEFLVYV 843
            ..|..:.|...::
Worm   801 GVLCAVLEHTHFI 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	82/400 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	20/87 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	123/387 (32%)
		Lig_chan	554..828	CDD:278489	86/274 (31%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	84/411 (20%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	121/369 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020